Cis-platinum (ii) complex of trans-l-1,2-diaminocyclohexane
Abstract
Abstract Cis-platinum (II) complexes of 1,2-diaminocyclohexanes, more particularly, cis-platinum (II) complexes represented by the general formula ##STR1## wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, trans-d- or trans-l-; and R 1 and R 2 , which are same, each represent a halogen atom, or R 1 and R 2 , when taken together, represent a group represented by the formula ##STR2## wherein R 3 represents a >CH 2 group, a >CHCH 3 or >CHCH 2 CH 3 group are disclosed. Further complexes of uracil and cis-[platinum(II)-cis-, trans-d or trans-l- 1,2-diaminocyclohexane] are disclosed. These complexes have anti-tumor activity in mice. Cis-platinum (II) complex of cis-1,2-diaminocyclohexane is most effective.
Inventors
- 👤 Yoshinori Kidani
- 👤 Kenji Inagaki
Bibliographic Details
Claims Analysis
Total Claims: 2References Cited (Backward Citations)
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