US4548939A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
Assignee: Janssen Pharmaceutica NV
•
Filing: 1984-10-01
•
Granted: 1985-10-22
•
Expires: 2004-10-01
Abstract
Abstract 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones having psychotropic activity.
Inventors
- 👤 Ludo E. J. Kennis
- 👤 Jan Vandenberk
- 👤 Jozef M. Boey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 11:47
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/08; A; A61; A61P; A61P1/00; A61P1/08; A61P25/00; A61P25/04; A61P25/20
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
53 words
A chemical compound having the formula ##STR6## and a pharmaceutically acceptable acid addition salt thereof, wherein Alk represents a bivalent lower alkyl radical; R is hydrogen, lower alkyl, halo, lower alkyloxy or hydroxy; the dotted line indicating that the double bond between the 3- and 4-carbon atoms of the piperidine nucleus is optional.
Claim 2
Dependent Claim
53 words
A chemical compound having the formula ##STR6## and a pharmaceutically acceptable acid addition salt thereof, wherein Alk represents a bivalent lower alkyl radical; R is hydrogen, lower alkyl, halo, lower alkyloxy or hydroxy; the dotted line indicating that the double bond between the 3- and 4-carbon atoms of the piperidine nucleus is optional.
Claim 3
Dependent Claim
18 words
A chemical compound selected from the group consisting of 7-[2-[4-(1H-indol-3-yl)-1-piperidinyl]ethyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione and the pharmaceutically acceptable acid addition salts thereof.
Claim 4
Dependent Claim
18 words
A chemical compound selected from the group consisting of 7-[2-[4-(1H-indol-3-yl)-1-piperidinyl]ethyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione and the pharmaceutically acceptable acid addition salts thereof.
Claim 5
Dependent Claim
89 words
A psychotropically effective composition having sedating, anxiolytic, anti-aggressive and anti-stress properties useful in the treatment of non-human warm-blooded animals comprising a suitable pharmaceutical carrier and as active ingredient a sedating, anxiolytic, anti-aggressive and anti-stress effecting amount of a compound having the formula ##STR7## and a pharmaceutically acceptable acid addition salt thereof, wherein Alk represents a bivalent lower alkyl radical; R is hydrogen, lower alkyl, halo, lower alkyloxy or hydroxy; the dotted line indicating that the double bond between the 3- and 4-carbon atoms of the piperidine nucleus is optional.
Claim 6
Dependent Claim
89 words
A psychotropically effective composition having sedating, anxiolytic, anti-aggressive and anti-stress properties useful in the treatment of non-human warm-blooded animals comprising a suitable pharmaceutical carrier and as active ingredient a sedating, anxiolytic, anti-aggressive and anti-stress effecting amount of a compound having the formula ##STR7## and a pharmaceutically acceptable acid addition salt thereof, wherein Alk represents a bivalent lower alkyl radical; R is hydrogen, lower alkyl, halo, lower alkyloxy or hydroxy; the dotted line indicating that the double bond between the 3- and 4-carbon atoms of the piperidine nucleus is optional.
Claim 7
Dependent Claim
25 words
A composition according to claim 3 wherein the compound is selected from the group consisting of 7-[2-[4-(1H-indol-3-yl-1-piperidinyl]ethyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione and the pharmaceutically acceptable acid addition salts thereof.
Claim 8
Independent Claim
86 words
A method of treating non-human warm-blooded animals by effecting sedating, anxiolytic, anti-aggressive and anti-stress activities which method comprises the systemic administration to warm-blooded animals of a sedating, anxiolytic, anti-agressive and anti-stress effecting amount of a compound having the formula ##STR8## and a pharmaceutically acceptable acid addition salt thereof, wherein Alk represents a bivalent lower alkyl radical; R is hydrogen, lower alkyl, halo, lower alkyloxy or hydroxy; the dotted line indicating that the double bond between the 3- and 4-carbon atoms of the piperidine nucleus is optional.
Claim 9
Independent Claim
86 words
A method of treating non-human warm-blooded animals by effecting sedating, anxiolytic, anti-aggressive and anti-stress activities which method comprises the systemic administration to warm-blooded animals of a sedating, anxiolytic, anti-agressive and anti-stress effecting amount of a compound having the formula ##STR8## and a pharmaceutically acceptable acid addition salt thereof, wherein Alk represents a bivalent lower alkyl radical; R is hydrogen, lower alkyl, halo, lower alkyloxy or hydroxy; the dotted line indicating that the double bond between the 3- and 4-carbon atoms of the piperidine nucleus is optional.
Claim 10
Dependent Claim
25 words
A method according to claim 5, wherein the compound is selected from the group consisting of 7-[2-[4-(1H-indol-3-yl)-1-piperidinyl]ethyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione and the pharmaceutically acceptable acid addition salts thereof.
References Cited (Backward Citations)
US3980658A
Cited
US4064255A
Cited
US4196209A
Cited
US4299832A
Cited
US4284633A
Cited
US4342870A
Cited
US4426383A
Cited
US4359468A
Cited
US4443451A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-10-21 | 1989-04-22 | 1989-10-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-10-21 | 1993-04-22 | 1993-10-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-10-21 | 1997-04-22 | 1997-10-22 | $7700.00 | Window Closed / Lapsed |