US4196209A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treating psychic disorders with piperidyl-indoles
Assignee: Sanofi Aventis France
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Filing: 1977-08-01
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Granted: 1980-04-01
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Expires: 1997-08-01
Abstract
Abstract Novel piperidyl-indoles of the formula ##STR1## wherein X is selected from the group consisting of fluorine, chlorine and bromine when Y and Z are hydrogen or together form a double bond and X is selected from the group consisting of hydrogen and alkoxy of 1 to 3 carbon atoms when Y and Z form a double bond and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressant, antiemetic and antiparkinsonian activity and their preparations and novel intermediates therefore.
Inventors
- 👤 Claude Dumont
- 👤 Jacques Guillaume
- 👤 Lucien Nedelec
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 06:28
CPC Classifications
C; C07; C07C; C07C55/00; C07C55/02; C07C55/10; A; A61; A61P; A61P1/00; A61P1/08; A61P25/00; A61P25/18
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
72 words
A compound selected from the group consisting of compounds of the formula ##STR9## wherein X is selected from the group consisting of fluorine, chlorine and bromine when Y and Z are hydrogen or together form a double bond and X is selected from the group consisting of hydrogen and alkoxy of 1 to 3 carbon atoms when Y and Z form a double bond and their non-toxic, pharmaceutically acceptable acid addition salts.
Claim 2
Dependent Claim
72 words
A compound selected from the group consisting of compounds of the formula ##STR9## wherein X is selected from the group consisting of fluorine, chlorine and bromine when Y and Z are hydrogen or together form a double bond and X is selected from the group consisting of hydrogen and alkoxy of 1 to 3 carbon atoms when Y and Z form a double bond and their non-toxic, pharmaceutically acceptable acid addition salts.
Claim 3
Dependent Claim
21 words
A compound of claim 1 wherein X is chlorine and Y and Z are hydrogen or together form a double bond.
Claim 4
Dependent Claim
20 words
A compound of claim 1 wherein Y and Z together form a double bond and X is hydrogen or methoxy.
Claim 5
Dependent Claim
9 words
A compound of claim 1 which is 5-chloro-3-(4-piperidyl)-1H-indole hydrochloride.
Claim 6
Dependent Claim
12 words
A compound of claim 1 which is the neutral succinate of 3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole.
Claim 7
Dependent Claim
12 words
A compound of claim 1 which is the neutral succinate of 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole.
Claim 8
Dependent Claim
12 words
A compound of claim 1 which is the neutral succinate of 4-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole
Claim 9
Dependent Claim
27 words
A composition for treating psychic disorders comprising an amount effective to combat psychic disorders of at least one compound of claim 1 and an inert pharmaceutical carrier.
Claim 10
Dependent Claim
21 words
A composition of claim 8 wherein X is chlorine and Y and Z are hydrogen or together form a double bond.
Claim 11
Dependent Claim
20 words
A composition of claim 8 wherein Y and Z together form a double bond and X is hydrogen or methoxy.
Claim 12
Dependent Claim
29 words
A method of treating psychic disorders in warmblooded animals comprising administering to warm-blooded aniamls an amount of at least one compound of claim 1 sufficient to relieve psychic disorders.
Claim 13
Dependent Claim
21 words
The method of claim 11 wherein X is chlorine and Y and Z are hydrogen or together form a double bond.
Claim 14
Dependent Claim
20 words
The method of claim 11 wherein Y and Z together form a double bond and X is hydrogen or methoxy.
Claim 15
Dependent Claim
11 words
The method of claim 11 wherein the compound is 5-chloro-3-(4-piperidyl)-1H-indole hydrochloride.
Claim 16
Dependent Claim
14 words
The method of claim 11 wherein the compound is the neutral succinate of 3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole.
Claim 17
Dependent Claim
14 words
The method of claim 11 wherein the compound in the neutral succinate of 4-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-01 | 1983-10-01 | 1984-04-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-01 | 1987-10-01 | 1988-04-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-01 | 1991-10-01 | 1992-04-01 | $7700.00 | Window Closed / Lapsed |