Pharmaceutical combination composition and associated method

Claim 1

A method for forming a granularly-heterogenous composition having combined pharmaceutically-effective diuretic anti-hypokalemic and antihypertensive activity comprising the steps of mixing finely-divided particles of a triamterene-active pteridine ingredient with at least one finely-divided pharmaceutically-acceptable inert ingredient to form a first mixture, and granulating said first mixture to form first granules composed of a homogeneous blend of the particles of said first mixture; separately mixing finely-divided particles of a hydrochlorothiazide-active benzothiadiazide ingredient with at least one finely-divided pharmaceutically-acceptable inert ingredient to form a second mixture, and separately granulating said second mixture to form second granules composed of a homogeneous blend of the particles of said second mixture; thereafter physically blending together said thusformed first and second granules while substantially retaining the respective identities of said first and second granules, in respective amounts such that in the resulting blended composition the weight ratio of said pteridine ingredient to said benzothiadiazide ingredient provides an effective bioavailable amount of said pteridine to control the hypokalemic condition induced by the dosage amount of said benzothiadiazide.

Claim 2

A method for forming a granularly-heterogenous composition having combined pharmaceutically-effective diuretic anti-hypokalemic and antihypertensive activity comprising the steps of mixing finely-divided particles of a triamterene-active pteridine ingredient with at least one finely-divided pharmaceutically-acceptable inert ingredient to form a first mixture, and granulating said first mixture to form first granules composed of a homogeneous blend of the particles of said first mixture; separately mixing finely-divided particles of a hydrochlorothiazide-active benzothiadiazide ingredient with at least one finely-divided pharmaceutically-acceptable inert ingredient to form a second mixture, and separately granulating said second mixture to form second granules composed of a homogeneous blend of the particles of said second mixture; thereafter physically blending together said thusformed first and second granules while substantially retaining the respective identities of said first and second granules, in respective amounts such that in the resulting blended composition the weight ratio of said pteridine ingredient to said benzothiadiazide ingredient provides an effective bioavailable amount of said pteridine to control the hypokalemic condition induced by the dosage amount of said benzothiadiazide.