Patent US4533540A successfully refreshed from Google Patents.
US4533540A
Expired / Lapsed
US
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Nitroglycerin-containing polymeric matrix for sustained release on topical application
Assignee: Forest Laboratories LLC
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Filing: 1984-08-30
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Granted: 1985-08-06
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Expires: 2004-08-30
Abstract
Abstract A mixture of nitroglycerin and a water-insoluble vinylpyrrolidone polymer provides a polymeric matrix which gradually releases nitroglycerin upon application to the skin of a patient in the form of a film, gel or ointment. The water-insoluble vinylpyrrolidone polymer may be an uncrosslinked copolymer or a crosslinked homopolymer or copolymer. The polymer provides increased stability and reduced volatility of the nitroglycerin while permitting slow and sustained release of the drug upon topical application to the skin.
Inventors
- 👤 Izhak Blank
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:37
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K31/00; A61K31/21; A61K47/00; A61K47/30; A61K47/32; A61K9/7061; A61P; A61P9/00; A61P9/08; A61P9/10
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
53 words
A composition for the sustained transdermal administration of nitroglycerin, comprising a film or solution containing a mixture of nitroglycerin and an uncrosslinked water-insoluble vinylpyrrolidone copolymer containing at least 10% by weight vinylpyrrolidone, wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 2
Dependent Claim
53 words
A composition for the sustained transdermal administration of nitroglycerin, comprising a film or solution containing a mixture of nitroglycerin and an uncrosslinked water-insoluble vinylpyrrolidone copolymer containing at least 10% by weight vinylpyrrolidone, wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 3
Dependent Claim
81 words
A composition for the sustained transdermal administration of nitroglycerin, comprising a film or solution containing a mixture of nitroglycerin and an uncrosslinked water-insoluble vinylpyrrolidone copolymer containing at least 10% by weight vinylpyrrolidone and units derived from an ester of an unsaturated acid selected from the group consisting of acrylic acid, methacrylic acid, crotonic acid, maleic acid and the corresponding anhydrides, wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 4
Dependent Claim
81 words
A composition for the sustained transdermal administration of nitroglycerin, comprising a film or solution containing a mixture of nitroglycerin and an uncrosslinked water-insoluble vinylpyrrolidone copolymer containing at least 10% by weight vinylpyrrolidone and units derived from an ester of an unsaturated acid selected from the group consisting of acrylic acid, methacrylic acid, crotonic acid, maleic acid and the corresponding anhydrides, wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 5
Dependent Claim
29 words
The composition of claim 2, wherein the ester is selected from the group consisting of the acrylic and methacrylic esters of C 4 -C 18 linear and branched alkanols.
Claim 6
Dependent Claim
11 words
The composition of claim 3, wherein the ester is lauryl methacrylate.
Claim 7
Dependent Claim
11 words
The composition of claim 3, wherein the ester is 2-ethylhexyl acrylate.
Claim 8
Dependent Claim
77 words
A composition for the sustained transdermal administration of nitroglycerin, comprising a film or solution containing a mixture of nitroglycerin and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer containing at least 10% by weight vinylpyrrolidone and units derived from an ester of a saturated acid selected from the group consisting of the vinyl and allyl esters of C 1 -C 40 carboxylic acids, wherein the nitroglycerin concentration is about 1% to about 6% of the total weight of the composition.
Claim 9
Dependent Claim
77 words
A composition for the sustained transdermal administration of nitroglycerin, comprising a film or solution containing a mixture of nitroglycerin and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer containing at least 10% by weight vinylpyrrolidone and units derived from an ester of a saturated acid selected from the group consisting of the vinyl and allyl esters of C 1 -C 40 carboxylic acids, wherein the nitroglycerin concentration is about 1% to about 6% of the total weight of the composition.
Claim 10
Dependent Claim
11 words
The composition of claim 6, wherein the ester is vinyl acetate.
Claim 11
Dependent Claim
56 words
A composition for the sustained transdermal administration of nitroglycerin, comprising a film or solution containing a mixture of nitroglycerin and an uncrosslinked water-insoluble copolymer of vinylpyrrolidone and styrene containing at least 10% by weight vinylpyrrolidone, wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 12
Dependent Claim
56 words
A composition for the sustained transdermal administration of nitroglycerin, comprising a film or solution containing a mixture of nitroglycerin and an uncrosslinked water-insoluble copolymer of vinylpyrrolidone and styrene containing at least 10% by weight vinylpyrrolidone, wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 13
Dependent Claim
36 words
The composition of claim 2, wherein the uncrosslinked water-insoluble vinylpyrrolidone copolymer contains units derived from an unsaturated acid selected from the group consisting of acrylic acid, methacrylic acid, crotonic acid, maleic acid and the corresponding anhydrides.
Claim 14
Dependent Claim
36 words
The composition of claim 6, wherein the uncrosslinked water-insoluble vinylpyrrolidone copolymer contains units derived from an unsaturated acid selected from the group consisting of acrylic acid, methacrylic acid, crotonic acid, maleic acid and the corresponding anhydrides.
Claim 15
Independent Claim
62 words
A method for providing for the sustained transdermal administration of nitroglycerin, which comprises applying to the skin of a patient a film or solution containing nitroglycerin and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer which contains at least 10% by weight of vinylpyrrolidone, wherein the nitroglycerin concentration is in the range of about 1% to about 6% of the total weight of the composition.
Claim 16
Independent Claim
62 words
A method for providing for the sustained transdermal administration of nitroglycerin, which comprises applying to the skin of a patient a film or solution containing nitroglycerin and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer which contains at least 10% by weight of vinylpyrrolidone, wherein the nitroglycerin concentration is in the range of about 1% to about 6% of the total weight of the composition.
Claim 17
Dependent Claim
14 words
The method of claim 11, wherein the solution is applied from an aerosol formulation.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-08-05 | 1989-02-04 | 1989-08-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-08-05 | 1993-02-04 | 1993-08-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-08-05 | 1997-02-04 | 1997-08-06 | $7700.00 | Window Closed / Lapsed |