US4482534A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nitroglycerin preparations
Assignee: Forest Laboratories LLC
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Filing: 1983-08-18
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Granted: 1984-11-13
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Expires: 2003-08-18
Abstract
Abstract A mixture of nitroglycerin and a water-insoluble vinylpyrrolidone polymer provides a polymeric matrix which gradually releases nitroglycerin upon application to the skin of a patient in the form of a film, gel or ointment. The water-insoluble vinylpyrrolidone polymer may be an uncrosslinked copolymer or a crosslinked homopolymer or copolymer. The polymer provides increased stability and reduced volatility of the nitroglycerin while permitting slow and sustained release of the drug upon topical application to the skin.
Inventors
- 👤 Izhak Blank
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:30
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K31/00; A61K31/21; A61K47/00; A61K47/30; A61K47/32; A61K9/7061; A61P; A61P9/00; A61P9/08; A61P9/10
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
70 words
A composition for the sustained transdermal administration of nitroglycerin, comprising an ointment base or gel containing a mixture of nitroglycerin and a water-insoluble vinylpyrrolidone polymer selected from the group consisting of (a) crosslinked vinylpyrrolidone homopolymer, and (b) crosslinked or uncrosslinked copolymer containing at least 10% by weight vinylpyrrolidone, and wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 2
Dependent Claim
70 words
A composition for the sustained transdermal administration of nitroglycerin, comprising an ointment base or gel containing a mixture of nitroglycerin and a water-insoluble vinylpyrrolidone polymer selected from the group consisting of (a) crosslinked vinylpyrrolidone homopolymer, and (b) crosslinked or uncrosslinked copolymer containing at least 10% by weight vinylpyrrolidone, and wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 3
Dependent Claim
82 words
A composition for the sustained transdermal administration of nitroglycerin, comprising an ointment base or gel containing a mixture of nitroglycerin and a water-insoluble vinylpyrrolidone copolymer which contains at least 10% by weight vinylpyrrolidone and units derived from an ester of an unsaturated acid selected from the group consisting of acrylic acid, methacrylic acid, crotonic acid, maleic acid and the corresponding anhydrides, wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 4
Dependent Claim
82 words
A composition for the sustained transdermal administration of nitroglycerin, comprising an ointment base or gel containing a mixture of nitroglycerin and a water-insoluble vinylpyrrolidone copolymer which contains at least 10% by weight vinylpyrrolidone and units derived from an ester of an unsaturated acid selected from the group consisting of acrylic acid, methacrylic acid, crotonic acid, maleic acid and the corresponding anhydrides, wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 5
Dependent Claim
12 words
The composition of claim 2, wherein the water-insoluble vinylpyrrolidone copolymer is crosslinked.
Claim 6
Dependent Claim
29 words
The composition of claim 2, wherein the ester is selected from the group consisting of the acrylic and methacrylic esters of C 4 -C 18 linear and branched alkanols.
Claim 7
Dependent Claim
11 words
The composition of claim 4, wherein the ester is lauryl methacrylate.
Claim 8
Dependent Claim
11 words
The composition of claim 4, wherein the ester is 2-ethylhexyl acrylate.
Claim 9
Dependent Claim
79 words
A composition for the sustained transdermal administration of nitroglycerin, comprising an ointment base or gel containing a mixture of nitroglycerin and a water-insoluble vinylpyrrolidone copolymer which contains at least 10% by weight of vinylpyrrolidone and units derived from an ester of a saturated acid selected from the group consisting of the vinyl and allyl esters of C 1 -C 40 carboxylic acids, wherein the nitroglycerin concentration is about 1% to about 6% of the total weight of the composition.
Claim 10
Dependent Claim
79 words
A composition for the sustained transdermal administration of nitroglycerin, comprising an ointment base or gel containing a mixture of nitroglycerin and a water-insoluble vinylpyrrolidone copolymer which contains at least 10% by weight of vinylpyrrolidone and units derived from an ester of a saturated acid selected from the group consisting of the vinyl and allyl esters of C 1 -C 40 carboxylic acids, wherein the nitroglycerin concentration is about 1% to about 6% of the total weight of the composition.
Claim 11
Dependent Claim
11 words
The composition of claim 7, wherein the ester is vinyl acetate.
Claim 12
Dependent Claim
57 words
A composition for the sustained transdermal administration of nitroglycerin, comprising an ointment base or gel containing a mixture of nitroglycerin and a water-insoluble copolymer of vinylpyrrolidone and styrene containing at least 10% by weight vinylpyrrolidone, and wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 13
Dependent Claim
57 words
A composition for the sustained transdermal administration of nitroglycerin, comprising an ointment base or gel containing a mixture of nitroglycerin and a water-insoluble copolymer of vinylpyrrolidone and styrene containing at least 10% by weight vinylpyrrolidone, and wherein the nitroglycerin concentration is within the range of about 1% to about 6% of the total weight of the composition.
Claim 14
Dependent Claim
35 words
The composition of claim 2, wherein the water-insoluble vinylpyrrolidone copolymer contains units derived from an unsaturated acid selected from the group consisting of acrylic acid, methacrylic acid, crotonic acid, maleic acid and the corresponding anhydrides.
Claim 15
Dependent Claim
35 words
The composition of claim 7, wherein the water-insoluble vinylpyrrolidone copolymer contains units derived from an unsaturated acid selected from the group consisting of acrylic acid, methacrylic acid, crotonic acid, maleic acid and the corresponding anhydrides.
Claim 16
Dependent Claim
18 words
The composition of claim 1, wherein the nitroglycerin and water-insoluble vinylpyrrolidone polymer are combined with an ointment base.
Claim 17
Dependent Claim
18 words
The composition of claim 2, wherein the nitroglycerin and water-insoluble vinylpyrrolidone copolymer are combined with an ointment base.
Claim 18
Dependent Claim
18 words
The composition of claim 7, wherein the nitroglycerin and water-insoluble vinylpyrrolidone copolymer are combined with an ointment base.
Claim 19
Dependent Claim
14 words
A bandage, gauze or tape impregnated or coated with the composition of claim 12.
Claim 20
Dependent Claim
14 words
A bandage, gauze or tape impregnated or coated with the composition of claim 15.
Claim 21
Dependent Claim
14 words
A bandage, gauze or tape impregnated or coated with the composition of claim 2.
Claim 22
Dependent Claim
14 words
A bandage, gauze or tape impregnated or coated with the composition of claim 13.
Claim 23
Dependent Claim
14 words
A bandage, gauze or tape impregnated or coated with the composition of claim 7.
Claim 24
Dependent Claim
14 words
A bandage, gauze or tape impregnated or coated with the composition of claim 14.
Claim 25
Dependent Claim
25 words
The composition of claim 1, wherein the nitroglycerin and water-insoluble vinylpyrrolidone polymer are combined with a solvent and a thickener to generate a gelled composition.
Claim 26
Dependent Claim
25 words
The composition of claim 2, wherein the nitroglycerin and water-insoluble vinylpyrrolidone copolymer are combined with a solvent and a thickener to generate a gelled composition.
Claim 27
Dependent Claim
25 words
The composition of claim 7, wherein the nitroglycerin and water-insoluble vinylpyrrolidone copolymer are combined with a solvent and a thickener to generate a gelled composition.
Claim 28
Dependent Claim
13 words
The composition of claim 21, wherein the thickener is a finely divided silica.
Claim 29
Dependent Claim
13 words
The composition of claim 22, wherein the thickener is a finely divided silica.
Claim 30
Dependent Claim
13 words
The composition of claim 23, wherein the thickener is a finely divided silica.
Claim 31
Independent Claim
62 words
A method for providing for the sustained transdermal administration of nitroglycerin, which comprises applying to the skin of a patient, a gel or ointment containing nitroglycerin and a water-insoluble vinylpyrrolidone polymer which contains at least 10% by weight of vinylpyrrolidone, and wherein the nitroglycerin concentration is in the range of about 1% to about 6% of the total weight of the composition.
Claim 32
Independent Claim
62 words
A method for providing for the sustained transdermal administration of nitroglycerin, which comprises applying to the skin of a patient, a gel or ointment containing nitroglycerin and a water-insoluble vinylpyrrolidone polymer which contains at least 10% by weight of vinylpyrrolidone, and wherein the nitroglycerin concentration is in the range of about 1% to about 6% of the total weight of the composition.
Claim 33
Dependent Claim
26 words
The method of claim 27, wherein the gel or ointment is applied on a carrier selected from the group consisting of a gauze, tape or bandage.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-11-13 | 1988-05-14 | 1988-11-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-11-13 | 1992-05-14 | 1992-11-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-11-13 | 1996-05-14 | 1996-11-13 | $7700.00 | Window Closed / Lapsed |