Patent US4525162A successfully refreshed from Google Patents.
US4525162A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Parenteral controlled delivery
Assignee: Alza Corp
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Filing: 1984-03-09
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Granted: 1985-06-25
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Expires: 2004-03-09
Abstract
Abstract A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
Inventors
- 👤 John Urquhart
- 👤 Felix Theeuwes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:47
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/1407
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
247 words
A method for administering a drug formulation to a recipient, the method comprising: (a) admitting intravenously into the recipient a delivery member in communication with an intravenously delivery system, said delivery system comprising: (1) a primary path in fluid communication with a primary container of a fluid for the flow of the fluid therethrough; (2) a secondary path in fluid communication with a secondary container of a fluid for the flow of the fluid therethrough; (3) a formulation chamber in fluid communication with the secondary path, the formulation chamber comprising; (i) a wall surrounding a lumen; (ii) inlet means for letting fluid into the chamber; (iii) outlet means for letting fluid leave the chamber; and, (iv) a drug in solid form in a means for releasing drug to fluid that enters the chamber and contacts the means to form a fluid drug formulation containing from a trace to a saturated amount of drug, said means maintaining its physical and chemical integrity in the presence of the fluid; (4) a common path for receiving fluid from the primary path and for receiving fluid from the secondary path, said common path in communication with the delivery member; (5) means for controlling fluid flow through the primary, secondary and common paths in fluid communication with the intravenous delivery system; and, (b) administering the drug formulation to the recipient by permitting fluid to flow into the formulation chamber and letting said drug formulation formed in situ flow into the common path.
Claim 2
Independent Claim
247 words
A method for administering a drug formulation to a recipient, the method comprising: (a) admitting intravenously into the recipient a delivery member in communication with an intravenously delivery system, said delivery system comprising: (1) a primary path in fluid communication with a primary container of a fluid for the flow of the fluid therethrough; (2) a secondary path in fluid communication with a secondary container of a fluid for the flow of the fluid therethrough; (3) a formulation chamber in fluid communication with the secondary path, the formulation chamber comprising; (i) a wall surrounding a lumen; (ii) inlet means for letting fluid into the chamber; (iii) outlet means for letting fluid leave the chamber; and, (iv) a drug in solid form in a means for releasing drug to fluid that enters the chamber and contacts the means to form a fluid drug formulation containing from a trace to a saturated amount of drug, said means maintaining its physical and chemical integrity in the presence of the fluid; (4) a common path for receiving fluid from the primary path and for receiving fluid from the secondary path, said common path in communication with the delivery member; (5) means for controlling fluid flow through the primary, secondary and common paths in fluid communication with the intravenous delivery system; and, (b) administering the drug formulation to the recipient by permitting fluid to flow into the formulation chamber and letting said drug formulation formed in situ flow into the common path.
Claim 3
Dependent Claim
39 words
The method for administering the drug formulation according to claim 1, wherein the intravenous delivery system comprises means for controlling fluid flow in the primary path, and the method further comprises controlling the fluid flow in the primary path.
Claim 4
Dependent Claim
45 words
The method for administering the drug formulation according to claim 1, wherein the delivery system comprises means for permitting fluid to flow into the formulation chamber, and the method further comprises permitting the flow of fluid in the secondary path for administering said drug formulation.
Claim 5
Dependent Claim
59 words
The method, for administering the drug formulation according to claim 1, wherein the delivery system comprises means for letting fluid flow in the primary path, and for letting drug formulation flow in the secondary path, and wherein the drug formulation is administered at predetermined periods by alternating the flow of fluid in the secondary and in the primary paths.
Claim 6
Independent Claim
237 words
A method for administering a drug formulation to a recipient, the method comprising: (a) admitting intravenously into the recipient a delivery member in communication with an intravenous delivery system, said delivery system comprising: (1) a primary path in communication with a primary container of a pharmaceutical fluid for the flow of fluid therethrough; (2) a second path in communication with a secondary container of a pharmaceutical fluid for the flow of fluid therethrough, said fluid a pharmaceutical carrier for the drug; (3) a formulation chamber in fluid communication with the secondary path, the formulation chamber comprising: (i) a wall surrounding a lumen; (ii) inlet means for letting fluid into the chamber; (iii) outlet means for letting fluid leave the chamber; (iv) a drug in solid form in the chamber that forms a fluid drug formulation containing from a trace to a saturating amount of drug with fluid that enters the chamber and contacts the drug; (4) a common path for receiving fluid from the primary path and for receiving drug formulation from the secondary path, said common path in communication with the delivery member; (5) means for controlling fluid flow through the primary, secondary and common paths in fluid communication with the intravenous delivery system; and, (b) administering the drug formulation to the recipient by permitting fluid to flow into the formulation chamber and by permitting the drug formulation formed in situ to enter the common path.
Claim 7
Independent Claim
237 words
A method for administering a drug formulation to a recipient, the method comprising: (a) admitting intravenously into the recipient a delivery member in communication with an intravenous delivery system, said delivery system comprising: (1) a primary path in communication with a primary container of a pharmaceutical fluid for the flow of fluid therethrough; (2) a second path in communication with a secondary container of a pharmaceutical fluid for the flow of fluid therethrough, said fluid a pharmaceutical carrier for the drug; (3) a formulation chamber in fluid communication with the secondary path, the formulation chamber comprising: (i) a wall surrounding a lumen; (ii) inlet means for letting fluid into the chamber; (iii) outlet means for letting fluid leave the chamber; (iv) a drug in solid form in the chamber that forms a fluid drug formulation containing from a trace to a saturating amount of drug with fluid that enters the chamber and contacts the drug; (4) a common path for receiving fluid from the primary path and for receiving drug formulation from the secondary path, said common path in communication with the delivery member; (5) means for controlling fluid flow through the primary, secondary and common paths in fluid communication with the intravenous delivery system; and, (b) administering the drug formulation to the recipient by permitting fluid to flow into the formulation chamber and by permitting the drug formulation formed in situ to enter the common path.
Claim 8
Dependent Claim
37 words
The method for administering the drug formulation according to claim 5, wherein the formulation chamber comprises a separate film formed of a material operable for the release of drug formulation from the chamber into the secondary path.
Claim 9
Dependent Claim
33 words
The method for administering the drug formulation according to claim 5, wherein the means controls fluid flow in the primary path and the means permits the flow of fluid in the common path.
Claim 10
Dependent Claim
47 words
The method for administering the drug formulation according to claim 5, wherein the means for controlling the flow of fluid permits fluid to flow in the secondary path into the formulation chamber and permits the flow of fluid in the common path for administering the drug formulation.
Claim 11
Dependent Claim
53 words
The method for administering the drug formulation according to claim 5 wherein the means lets fluid flow from the primary path and lets drug formulation flow from the secondary path, and wherein the drug formulation is administered at predetermined periods by alternating the flow of fluid in the secondary and the primary paths.
Claim 12
Dependent Claim
20 words
The method for administering the drug formulation according to claim 5, wherein the intravenous delivery system comprises a drip chamber.
Claim 13
Dependent Claim
46 words
The method for administering the drug formulation according to claim 5, wherein the formulation chamber comprises a film that supports the drug in solid form, said form a member selected from the group consisting of crystalline, particle, pellet, powder, dried, lyophilized and tablet pharmaceutically acceptable forms.
Claim 14
Dependent Claim
181 words
An intravenous delivery set for administering an intravenous fluid and a fluid drug formulation to a recipient wherein the set comprises: (a) a primary path for the flow of the intravenous fluid therethrough; (b) a secondary path for the flow of an intravenous fluid therethrough; (c) a formulation chamber in communication with the secondary path, the formulation chamber comprising: (i) a wall surrounding a lumen; (ii) an inlet for letting fluid from the secondary path into the formulation chamber; (iii) a drug in pharmaceutically acceptable solid form in the formulation chamber that forms a fluid drug formulation with fluid that enters the chamber and contacts the drug; (iv) an outlet for letting drug formulation leave the chamber; (d) a common path in communication with the primary path for receiving fluid from the primary path, and in communication with the secondary path for receiving drug formulation from the secondary path; and, (e) means for permitting, in either instance, fluid from the primary path, drug formulation from the secondary path, and concomitantly fluid and drug formulation from both paths into the common path.
Claim 15
Dependent Claim
181 words
An intravenous delivery set for administering an intravenous fluid and a fluid drug formulation to a recipient wherein the set comprises: (a) a primary path for the flow of the intravenous fluid therethrough; (b) a secondary path for the flow of an intravenous fluid therethrough; (c) a formulation chamber in communication with the secondary path, the formulation chamber comprising: (i) a wall surrounding a lumen; (ii) an inlet for letting fluid from the secondary path into the formulation chamber; (iii) a drug in pharmaceutically acceptable solid form in the formulation chamber that forms a fluid drug formulation with fluid that enters the chamber and contacts the drug; (iv) an outlet for letting drug formulation leave the chamber; (d) a common path in communication with the primary path for receiving fluid from the primary path, and in communication with the secondary path for receiving drug formulation from the secondary path; and, (e) means for permitting, in either instance, fluid from the primary path, drug formulation from the secondary path, and concomitantly fluid and drug formulation from both paths into the common path.
Claim 16
Dependent Claim
58 words
The intravenous delivery set for administering the intravenous fluid and the drug formulation according to claim 12, wherein the formulation chamber houses a film formed of a material operable for the release of drug formulation, and the drug is a member selected from the group consisting of crystalline, particle, pellet, powder, dried, lyophilized and tablet pharmaceutically acceptable forms.
Claim 17
Dependent Claim
25 words
The intravenous delivery set for administering the intravenous fluid and the drug formulation according to claim 12, wherein the administration set comprises a drip chamber.
Claim 18
Dependent Claim
32 words
The intravenous delivery set for administering the intravenous fluid and the drug formulation according to claim 12, wherein the set provides continuous agent administration, interrupted agent administration, and intervals of agent-free administration.
Claim 19
Dependent Claim
44 words
The intravenous delivery set for administering the intravenous fluid and the drug formulation according to claim 12, wherein fluid enters the formulation chamber, contacts the drug and forms in situ a fluid drug formulation containing from a trace to a saturating amount of drug.
Claim 20
Dependent Claim
199 words
An intravenous delivery set for administering an intravenous fluid and a fluid drug formulation to a recipient wherein the set comprises: (a) a primary path for the flow of the intravenous fluid therethrough; (b) a secondary path for the flow of an intravenous fluid therethrough; (c) a formulation chamber in communication with the secondary path, the formulation chamber comprising: (i) a wall surrounding a lumen; (ii) an inlet for letting fluid from the secondary path into the formulation chamber; (iii) a drug in solid pharmaceutically acceptable form in means for storing and releasing said drug to fluid that enters the chamber and contacts the means to form a fluid drug formulation, said means maintaining its physical and chemical integrity in the presence of the fluid; (iv) an outlet for letting drug formulation leave the chamber; (d) a common path in communication with the primary path for receiving fluid from the primary path and in communication with the secondary path for receiving drug formulation from the secondary path; and, (e) means for permitting, in either instance, fluid from the primary path, drug formulation from the secondary path, and concomitantly fluid and drug formulation from both paths into the common path.
Claim 21
Dependent Claim
199 words
An intravenous delivery set for administering an intravenous fluid and a fluid drug formulation to a recipient wherein the set comprises: (a) a primary path for the flow of the intravenous fluid therethrough; (b) a secondary path for the flow of an intravenous fluid therethrough; (c) a formulation chamber in communication with the secondary path, the formulation chamber comprising: (i) a wall surrounding a lumen; (ii) an inlet for letting fluid from the secondary path into the formulation chamber; (iii) a drug in solid pharmaceutically acceptable form in means for storing and releasing said drug to fluid that enters the chamber and contacts the means to form a fluid drug formulation, said means maintaining its physical and chemical integrity in the presence of the fluid; (iv) an outlet for letting drug formulation leave the chamber; (d) a common path in communication with the primary path for receiving fluid from the primary path and in communication with the secondary path for receiving drug formulation from the secondary path; and, (e) means for permitting, in either instance, fluid from the primary path, drug formulation from the secondary path, and concomitantly fluid and drug formulation from both paths into the common path.
Claim 22
Dependent Claim
27 words
The intravenous delivery set for administering the intravenous fluid and the drug formulation according to claim 17, wherein the administration set comprises at least one drip chamber.
Claim 23
Dependent Claim
32 words
The intravenous delivery set for administering the intravenous fluid and the drug formulation according to claim 17, wherein the set provides continuous agent administration interrupted agent administration, and intervals of agent-free administration.
Claim 24
Dependent Claim
41 words
The intravenous delivery set for administering the intravenous fluid and the drug formulation according to claim 17, wherein fluid enters the formulation chamber and forms in situ a fluid drug formulation containing from a trace to a saturating amount of drug.
Claim 25
Dependent Claim
193 words
An intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation to a recipient, wherein the system comprises: (a) a primary container of an intravenously acceptable fluid; (b) a primary path in fluid communication with the primary container; (c) a secondary container of an intravenously acceptable fluid; (d) a secondary path in fluid communication with the secondary container; (e) a formulation chamber in fluid communication with the secondary path, the formulation chamber comprising: (i) a wall that surrounds a lumen; (ii) an inlet for letting fluid enter the chamber; (iii) a beneficial drug in a solid form in the chamber that forms a fluid drug formulation with fluid that enters the chamber and contacts the drug; (iv) an outlet for letting drug formulation leave the chamber; (f) a common path in communication with the primary path for receiving fluid from the primary path, and in communication with the secondary path for receiving drug formulation from the secondary path; and, (g) means for permitting, in either instance, fluid from the primary path, drug formulation from the secondary path, and concomitantly fluid and drug formulation from both paths into the common path.
Claim 26
Dependent Claim
193 words
An intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation to a recipient, wherein the system comprises: (a) a primary container of an intravenously acceptable fluid; (b) a primary path in fluid communication with the primary container; (c) a secondary container of an intravenously acceptable fluid; (d) a secondary path in fluid communication with the secondary container; (e) a formulation chamber in fluid communication with the secondary path, the formulation chamber comprising: (i) a wall that surrounds a lumen; (ii) an inlet for letting fluid enter the chamber; (iii) a beneficial drug in a solid form in the chamber that forms a fluid drug formulation with fluid that enters the chamber and contacts the drug; (iv) an outlet for letting drug formulation leave the chamber; (f) a common path in communication with the primary path for receiving fluid from the primary path, and in communication with the secondary path for receiving drug formulation from the secondary path; and, (g) means for permitting, in either instance, fluid from the primary path, drug formulation from the secondary path, and concomitantly fluid and drug formulation from both paths into the common path.
Claim 27
Dependent Claim
30 words
The intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation according to claim 21, wherein a drip chamber is in fluid communication with the primary path.
Claim 28
Dependent Claim
30 words
The intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation according to claim 21, wherein a drip chamber is in fluid communication with the secondary path.
Claim 29
Dependent Claim
43 words
The intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation according to claim 21, wherein the formulation chamber comprises a film formed of a material operable for the release of drug formulation from the chamber into the secondary path.
Claim 30
Dependent Claim
33 words
The intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation according to claim 21, wherein the system provides continuous agent administration, interrupted agent administration, and intervals of agent-free administration.
Claim 31
Dependent Claim
45 words
The intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation according to claim 21, wherein fluid enters the formulation chamber, contacts the drug and forms in situ a fluid drug formulation containing from a trace to a saturating amount of drug.
Claim 32
Dependent Claim
53 words
The intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation according to claim 21, wherein the formulation chamber comprise a film that supports the drug in solid form, said form a member selected from the group consisting of crystalline, particle, pellet, powder, dried, lyophilized and tablet pharmaceutically acceptable forms.
Claim 33
Dependent Claim
211 words
An intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation to a recipient, wherein the system comprises: (a) a primary container of an intravenously acceptable fluid; (b) a primary path in fluid communication with the primary container; (c) a secondary container of an intravenously acceptable fluid; (d) a secondary path in fluid communication with the secondary container; (e) a formulation chamber in fluid communication with the secondary path, the formulation chamber comprising: (i) a wall that surrounds a lumen; (ii) an inlet for letting fluid enter the chamber; (iii) means for housing a beneficial drug in a solid form and for releasing the drug to fluid that enters the chamber and contacts the means to form a fluid drug formulation, said means maintaining its physical and chemical integrity in the presence of fluid; (iv) an outlet for letting drug formulation leave the chamber; (f) a common path in communication with the primary path for receiving fluid from the primary path, and in communication with the secondary path for receiving drug formulation from the secondary path; and, (g) means for permitting, in either instance fluid from the primary path, drug formulation from the secondary path, and concomitantly fluid and drug formulation from both paths into the common path.
Claim 34
Dependent Claim
211 words
An intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation to a recipient, wherein the system comprises: (a) a primary container of an intravenously acceptable fluid; (b) a primary path in fluid communication with the primary container; (c) a secondary container of an intravenously acceptable fluid; (d) a secondary path in fluid communication with the secondary container; (e) a formulation chamber in fluid communication with the secondary path, the formulation chamber comprising: (i) a wall that surrounds a lumen; (ii) an inlet for letting fluid enter the chamber; (iii) means for housing a beneficial drug in a solid form and for releasing the drug to fluid that enters the chamber and contacts the means to form a fluid drug formulation, said means maintaining its physical and chemical integrity in the presence of fluid; (iv) an outlet for letting drug formulation leave the chamber; (f) a common path in communication with the primary path for receiving fluid from the primary path, and in communication with the secondary path for receiving drug formulation from the secondary path; and, (g) means for permitting, in either instance fluid from the primary path, drug formulation from the secondary path, and concomitantly fluid and drug formulation from both paths into the common path.
Claim 35
Dependent Claim
30 words
The intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation according to claim 28, wherein a drip chamber is in fluid communication with the primary path.
Claim 36
Dependent Claim
30 words
The intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation according to claim 28, wherein a drip chamber is in fluid communication with the secondary path.
Claim 37
Dependent Claim
26 words
The intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation according to claim 28, wherein the means is a drug delivery device.
Claim 38
Dependent Claim
33 words
The intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation according to claim 28, wherein the system provides continuous agent administration, interrupted agent administration, and intervals of agent-free administration.
Claim 39
Dependent Claim
45 words
The intravenous delivery system for administering a beneficial fluid and a beneficial drug formulation according to claim 28, wherein fluid enters the formulation chamber, contacts the drug and forms in situ a fluid drug formulation containing from a trace to a saturating amount of drug.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-24 | 1988-12-24 | 1989-06-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-24 | 1992-12-24 | 1993-06-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-24 | 1996-12-24 | 1997-06-25 | $7700.00 | Window Closed / Lapsed |