Thieno and furopyridinium-substituted cephalosporins

Claim 1

The compound of the formula ##STR31## wherein R is an acyl group of the formula ##STR32## wherein R' is a 5- or 6-membered heterocyclic ring of the formulas ##STR33## R" is hydrogen, C 1 -C 4 alkyl, a carboxy-substituted alkyl or carboxy-substituted cycloalkyl group of the formula ##STR34## wherein n is 0-3; a and b when taken separately are independently hydrogen or C 1 -C 3 alkyl, and when taken together with the carbon to which they are bonded form a C 3 -C 7 carbocyclic ring; R'" is hydroxy, C 1 C 4 alkoxy, amino, or OR°, wherein R° is indanyl, phthalidyl, or an acyloxymethyl group of the formula --CH 2 --O--C(O)--R 2 wherein R 2 is C 1 -C 4 alkyl or phenyl; or R° is a carboxy-protecting group; or R" is an N-substituted carbamoyl group of the formula ##STR35## wherein R"" is C 1 -C 4 alkyl, phenyl or C 1 -C 3 alkyl substituted by phenyl; .sup.⊕ R 1 is a bicyclicpyridinium group selected from the group consisting of a thienopyridinium group of the formulas ##STR36## or a furopyridinium group of the formulas ##STR37## and said thienopyridinium and said furopyridinium wherein either or both of the hetero rings thereof is substituted by one or two C 1 -C 4 alkyl, halogen, carboxy, carbamoyl, C 1 -C 4 alkoxycarbonyl groups, --SO 3 H, hydroxy, C 1 -C 4 alkoxy, amino, mono-(C 1 -C 4 alkyl)amino, di-(C 1 -C 4 alkyl)amino, C 2 -C 4 alkanoylamino, aminosulfonyl, cyano, formyl, trifluoromethyl, or a hydroxyamido group of the formula ##STR38## wherein R 3 and R 4 independently are hydrogen or C 1 -C 4 alkyl; and the pharmaceutically acceptable non-toxic salts thereof.