US4278671A
Expired / Lapsed
US
⏱️ 0.0 years remaining
7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido] cephalosporins
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1979-08-08
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Granted: 1981-07-14
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Expires: 1999-08-08
Abstract
Abstract A 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido] cephalosporin derivative of the formula; <IMAGE> wherein R3 is hydrogen or a residue of a nucleophilic compound; R2NH is an amino group which may optionally be protected, pharmaceutically acceptable salt or ester thereof, is found to have excellent anti-bacterial activity against a broad spectrum of bacteria inclusive of gram-negative bacteria such as Escherichia coli, Serratia marcescens, Proteus rettgeri, Enterobacter cloacae and Citrobacter freundii. Thus, this compound may be used for an antibacterial agent in therapeutical purposes.
Inventors
- 👤 Michihiko Ochiai
- 👤 Akira Morimoto
- 👤 Yoshihiro Matsushita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 06:43
CPC Classifications
C; C07; C07D; C07D257/00; C07D257/02; C07D257/04; C07D277/00; C07D277/02; C07D277/20; C07D277/587
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
30 words
A member selected from the group consisting of a 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin compound of the formula: ##STR77## wherein R 3 is pyridinium or 4-carbamoylpyridinium, and a pharmaceutically acceptable salt or ester thereof.
Claim 2
Dependent Claim
30 words
A member selected from the group consisting of a 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin compound of the formula: ##STR77## wherein R 3 is pyridinium or 4-carbamoylpyridinium, and a pharmaceutically acceptable salt or ester thereof.
Claim 3
Dependent Claim
52 words
An antibacterial composition which comprises (a) an antibacterially effective amount of a member selected from the group consisting of a 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin compound of the formula: ##STR78## wherein R 3 is pyridinium or 4-carbamoylpyridinium, and a pharmaceutically acceptable salt or ester thereof in admixture with (b) a pharmaceutically acceptable excipient or diluent therefor.
Claim 4
Dependent Claim
52 words
An antibacterial composition which comprises (a) an antibacterially effective amount of a member selected from the group consisting of a 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin compound of the formula: ##STR78## wherein R 3 is pyridinium or 4-carbamoylpyridinium, and a pharmaceutically acceptable salt or ester thereof in admixture with (b) a pharmaceutically acceptable excipient or diluent therefor.
Claim 5
Dependent Claim
12 words
A compound as claimed in claim 1, wherein the compound is 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-pyridiniummethyl-3-cephem-4-carboxylate.
Claim 6
Dependent Claim
12 words
A compound as claimed in claim 1, wherein the compound is 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-(4-carbamoylpyridinium)methyl-3-cephem-4-carboxylate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-07-13 | 1985-01-12 | 1985-07-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-07-13 | 1989-01-12 | 1989-07-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-07-13 | 1993-01-12 | 1993-07-14 | $7700.00 | Window Closed / Lapsed |