Patent US4478816A successfully refreshed from Google Patents.
US4478816A
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Rare earth/chelating agent complex for digital fluoroscopy
Assignee: Georgetown University
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Filing: 1982-06-07
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Granted: 1984-10-23
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Expires: 2002-06-07
Abstract
Abstract A rare earth/chelating agent complex is employed in digital fluoroscopy. More specifically, a contrast medium is utilized in digital fluoroscopy, the contrast medium consisting of a non-radioactive composition of a rare earth metal and a chelating agent. The rare earth metal is lutecium or ytterbium, while the chelating agent is DTPA, EHPG or HBED. The digital fluoroscopy method results in the development of diagnostic energy difference image information as a result of application of X-ray beams of two different energy levels, coupled with subtraction processing of the resulting image information.
Inventors
- 👤 Robert S. Ledley
- 👤 Edward J. Zapolski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 09:50
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
94 words
A method of obtaining diagnostic energy difference image information of a patient, comprising the steps of: (a) injecting a sterile aqueous solution comprising an effective amount of a non-radioactive rare earth metal and a chelating agent into the patient intraveneously; (b) applying an X-ray beam having a first energy level to the paitent to obtain first image information; (c) applying an X-ray beam having second energy level to the patient to obtain a second image information; and (d) subtraction processing the first and second image informations to obtain the diagnostic energy difference image information.
Claim 2
Independent Claim
94 words
A method of obtaining diagnostic energy difference image information of a patient, comprising the steps of: (a) injecting a sterile aqueous solution comprising an effective amount of a non-radioactive rare earth metal and a chelating agent into the patient intraveneously; (b) applying an X-ray beam having a first energy level to the paitent to obtain first image information; (c) applying an X-ray beam having second energy level to the patient to obtain a second image information; and (d) subtraction processing the first and second image informations to obtain the diagnostic energy difference image information.
Claim 3
Dependent Claim
16 words
The method of claim 1, further comprising step (e) of displaying the energy difference image information.
Claim 4
Dependent Claim
20 words
The method of claim 1, wherein said rare earth metal is selected from the class consisting of lutetium and ytterbium.
Claim 5
Dependent Claim
13 words
The method of claim 1, wherein said chelating agent is diethylenetriamine pentaacetic acid.
Claim 6
Dependent Claim
13 words
The method of claim 1, wherein said chelating agent is ethylenediamine-N,N'-bis (2-hydroxy-phenylacetic acid).
Claim 7
Dependent Claim
14 words
The method of claim 1, wherein said chelating agent is N,N'-bis (2-hydroxbenzyl) ethylene-diamine-N,N'-diacetic acid.
References Cited (Backward Citations)
US3480715A
Cited
US3663688A
Cited
US4017596A
Cited
US3995020A
Cited
US4176173A
Cited
US4283382A
Cited
US4310507A
Cited
US4192859A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-23 | 1988-04-23 | 1988-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-23 | 1992-04-23 | 1992-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-23 | 1996-04-23 | 1996-10-23 | $7700.00 | Window Closed / Lapsed |