US4176173A
Expired / Lapsed
US
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Radiographic compositions
Assignee: Medi Physics Inc
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Filing: 1977-07-18
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Granted: 1979-11-27
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Expires: 1997-07-18
Abstract
Abstract Radiographic contrast media preparations suitable for use with high-energy x-ray sources and useful for intestinal tract studies and, in particular, computerized tomography are disclosed. The disclosed preparations comprise aqueous solutions of stable, non-toxic complexes of hafnium and tantalum with certain organic acids.
Inventors
- 👤 Harry S. Winchell
- 👤 Tz-Hong Lin
- 👤 Charles A. Panneciere
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:35
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; A; A61; A61K; A61K49/00; A61K49/04; C07C; C07C59/00; C07C59/01; C07C59/10; C07C59/105; C07C59/235; C07C59/245; C07C59/255; C07C59/265; C07D; C07D307/00; C07D307/02; C07D307/34; C07D307/56; C07D307/62
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
182 words
A method of preparing a patient for radiographic examination of the gastrointestinal tract which comprises orally administering to said patient an amount of a composition comprising an aqueous solution of a stable, non-toxic, hydrated complex of a metal selected from the group consisting of hafnium and tantalum and an organic acid complexing agent selected from the group consisting of: (a) an organic acid containing from 2 to 7 carbon atoms and at least one hydroxyl group; (b) an amino acid containing from 2 to 7 carbon atoms: and (c) a phosphonic acid selected from the group consisting of ethylenediaminetetramethylenephosphonic acid, diethylenepentamethylenephosphonic acid and diphosphonic acids represented by the formula ##STR2## wherein R 1 and R 2 are the same or different and are selected from the group consisting of hydrogen, lower alkyl, amino, halogen, hydroxyl and --CH 2 --COOH and pharmaceutically acceptable salts thereof, said salts being selected from the group consisting of the ammonium salt, the sodium salt and the potassium salt, said composition containing from about 1% to about 25% weight to volume of said metal, effective for said examination.
Claim 2
Independent Claim
182 words
A method of preparing a patient for radiographic examination of the gastrointestinal tract which comprises orally administering to said patient an amount of a composition comprising an aqueous solution of a stable, non-toxic, hydrated complex of a metal selected from the group consisting of hafnium and tantalum and an organic acid complexing agent selected from the group consisting of: (a) an organic acid containing from 2 to 7 carbon atoms and at least one hydroxyl group; (b) an amino acid containing from 2 to 7 carbon atoms: and (c) a phosphonic acid selected from the group consisting of ethylenediaminetetramethylenephosphonic acid, diethylenepentamethylenephosphonic acid and diphosphonic acids represented by the formula ##STR2## wherein R 1 and R 2 are the same or different and are selected from the group consisting of hydrogen, lower alkyl, amino, halogen, hydroxyl and --CH 2 --COOH and pharmaceutically acceptable salts thereof, said salts being selected from the group consisting of the ammonium salt, the sodium salt and the potassium salt, said composition containing from about 1% to about 25% weight to volume of said metal, effective for said examination.
Claim 3
Dependent Claim
32 words
A method of preparing a patient in accordance with claim 1 wherein said metal is hafnium and said organic acid complexing agent is selected from those acids in groups (a) and (b).
Claim 4
Dependent Claim
32 words
A method of preparing a patient in accordance with claim 2 wherein said organic acid complexing agent is selected from the group consisting of gluconic acid, glyceric acid, citric and ascorbic acid.
Claim 5
Dependent Claim
17 words
A method of preparing a patient in accordance with claim 3 wherein said complex is hydrated hafnium-ammonium-gluconate.
Claim 6
Dependent Claim
32 words
A method of preparing a patient in accordance with claim 1 wherein said metal is tantalum and said organic acid complexing agent is selected from those acids in groups (a) and (c).
Claim 7
Dependent Claim
31 words
A method of preparing a patient in accordance with claim 5 wherein said organic acid complexing agent is selected from the group consisting of citric acid, tartaric acid and ethane-1-hydroxy-1,1-diphosphonic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-11-26 | 1983-05-28 | 1983-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-11-26 | 1987-05-28 | 1987-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-11-26 | 1991-05-28 | 1991-11-27 | $7700.00 | Window Closed / Lapsed |