US4462980A
Expired / Lapsed
US
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Stabilized plasmin compositions and method for preparation thereof
Assignee: Novo Nordisk AS
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Filing: 1982-01-04
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Granted: 1984-07-31
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Expires: 2002-01-04
Abstract
Abstract Novel plasmin compositions, conditioned for labelling with technetium-99m by containing a pertechnetate reducing reagent, and plasmin admixed with a plasmin stabilizing agent. The novel compositions are particularly suited for the preparation of technetium-99m labelled plasmin used as a scintigraphic scanning agent for the detection of venous thrombosis.
Inventors
- 👤 Allan Diedrichsen
- 👤 Marie Johannessen
- 👤 Peter Tang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 11:55
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/6435; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/12; C12N9/96; C12Y; C12Y304/00; C12Y304/21; C12Y304/21007; A61K2123/00; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
62 words
A solid form plasmin composition adapted for labelling with technetium-99m by being admixed with a pertechnetate reducing agent, which composition comprises plasmin, a pertechnetate reducing agent and an effective amount of a plasmin stabilizing polyhydroxy compound selected from the group consisting of the pentitols xylitol and ribitol, meso-inositol, the monosaccharides glucose, mannose, galactose, fructose, and sorbose and the disaccharides sucrose and maltose.
Claim 2
Dependent Claim
62 words
A solid form plasmin composition adapted for labelling with technetium-99m by being admixed with a pertechnetate reducing agent, which composition comprises plasmin, a pertechnetate reducing agent and an effective amount of a plasmin stabilizing polyhydroxy compound selected from the group consisting of the pentitols xylitol and ribitol, meso-inositol, the monosaccharides glucose, mannose, galactose, fructose, and sorbose and the disaccharides sucrose and maltose.
Claim 3
Dependent Claim
13 words
The composition according to claim 1, wherein the plasmin is of porcine origin.
Claim 4
Dependent Claim
22 words
The composition according to claim 1, wherein the pertechnetate reducing agent stannous chloride in an effective amount forms part of the composition.
Claim 5
Dependent Claim
47 words
The composition according to claim 3, wherein the amount of stannous chloride is in the range of from 0.8 to 16 percent by weight of plasmin, the amount of plasmin being calculated on the basis of a product with an activity of 3.5 NOVO units per mg.
Claim 6
Dependent Claim
24 words
The composition according to claim 4, wherein the amount of stannous chloride is in the range of from 2 to 8 percent by weight.
Claim 7
Dependent Claim
24 words
A composition according to claim 1, wherein the weight ratio of polyhydroxy compound to plasmin is in the range of from 0.1:1 to 10:1.
Claim 8
Dependent Claim
22 words
The composition according to claim 6, wherein the weight ratio of polyhydroxy compound is in the range of from 0.5:1 to 5:1.
Claim 9
Dependent Claim
15 words
A composition according to claim 1, wherein the polyhydroxy compound is a mono- or disaccharide.
Claim 10
Dependent Claim
21 words
A composition according to claim 8, wherein the polyhydroxy compound is selected from the group consisting of fructose; sucrose, and maltose.
Claim 11
Independent Claim
77 words
A method of preparing a solid form plasmin composition adapted for labelling with technetium-99m by being admixed with a pertechnetate reducing agent, which method comprises admixing in solution plasmin a pertechnetate reducing agent and an effective amount of a plasmin stabilizing polyhydroxy compound selected from the group consisting of the pentitols xylitol and ribitol meso-inositol the monosaccharides glucose, mannose, galactose, fructose and sorbose, and the disaccharides sucrose and maltose, followed by lyophilizing the mixture to solid form.
Claim 12
Independent Claim
77 words
A method of preparing a solid form plasmin composition adapted for labelling with technetium-99m by being admixed with a pertechnetate reducing agent, which method comprises admixing in solution plasmin a pertechnetate reducing agent and an effective amount of a plasmin stabilizing polyhydroxy compound selected from the group consisting of the pentitols xylitol and ribitol meso-inositol the monosaccharides glucose, mannose, galactose, fructose and sorbose, and the disaccharides sucrose and maltose, followed by lyophilizing the mixture to solid form.
Claim 13
Dependent Claim
18 words
The method of claim 10 comprising admixing with the plasmin in solution an effective amount of stannous chloride.
Claim 14
Dependent Claim
31 words
A method for labelling plasmin wherein the solid form plasmin containing composition of claim 3 is dissolved and then reacted with pertechnetate in solution to form thereby the technetium-99m labelled plasmin.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-31 | 1988-01-30 | 1988-07-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-31 | 1992-01-30 | 1992-07-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-31 | 1996-01-30 | 1996-07-31 | $7700.00 | Window Closed / Lapsed |