US4297344A
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Blood coagulation factors and process for their manufacture
Assignee: Centeon Pharma GmbH
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Filing: 1980-04-23
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Granted: 1981-10-27
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Expires: 2000-04-23
Abstract
Abstract A process for stabilizing the coagulation factors II, VIII, XIII, antithrombin III and plasminogen against heat is described. The preparations obtained according to this process are practically free from coagulable fibrinogen.
Inventors
- 👤 Horst Schwinn
- 👤 Norbert Heimburger
- 👤 Gerhardt Kumpe
- 👤 Bernd Herchenhan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:18
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/10; C12N9/1025; C12N9/104; C12N9/1044; A; A61; A61K; A61K31/00; A61K31/13; A61K31/14; A61K35/00; A61K35/12; A61K35/14; A61K38/00; A61K38/005; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61L; A61L2/00; A61L2/02; A61L2/04; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/75; C07K14/755; C07K14/81; C07K14/8107; C07K14/811; C07K14/8121; C07K14/8128; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/6429; C12N9/6435; C12Y; C12Y304/00; C12Y304/21; C12Y304/21005; C12Y304/21007; A61L2103/00; A61L2103/05; A61L2103/09; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83; Y10S530/831; Y10S530/85; Y10S530/851
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
88 words
A method for stabilizing against heat an aqueous solution containing at least one member selected from the group consisting of coagulation factors II, VIII, XIII, antithrombin III, and plasminogen, which method comprises adding to said solution from 1.0 to 3.0 mols per liter of at least one amino acid selected from the group consisting of glycine, α- and β-alanine, hydroxyproline, glutamine, and α-, β-, and γ-aminobutyric acid and from 20 to 60 w/w percent of a carbohydrate selected from the group consisting of monosaccharides, oligosaccharides, and sugar alcohols.
Claim 2
Independent Claim
88 words
A method for stabilizing against heat an aqueous solution containing at least one member selected from the group consisting of coagulation factors II, VIII, XIII, antithrombin III, and plasminogen, which method comprises adding to said solution from 1.0 to 3.0 mols per liter of at least one amino acid selected from the group consisting of glycine, α- and β-alanine, hydroxyproline, glutamine, and α-, β-, and γ-aminobutyric acid and from 20 to 60 w/w percent of a carbohydrate selected from the group consisting of monosaccharides, oligosaccharides, and sugar alcohols.
Claim 3
Dependent Claim
17 words
A method as in claim 1 wherein said amino acid is glycine and said carbohydrate is saccharose.
Claim 4
Independent Claim
154 words
A method for making a hepatitis-safe preparation of at least one member selected from the group consisting of coagulation factors II, VIII, XIII, antithrombin III, and plasminogen, which method comprises first stabilizing against heat an aqueous solution containing at least one of said members by adding to said solution from 1.0 to 3.0 mols per liter of at least one amino acid selected from the group consisting of glycine, α- and β-alanine, hydroxyproline, glutamine, and α-, β-, and γ-aminobutyric acid and from 20 to 60 w/w percent of a carbohydrate selected from the group consisting of monosaccharides, oligosaccharides, and sugar alcohols, then heating the resulting heat-stabilized aqueous solution at a temperature from 30° C. to 100° C. for a period of time from one minute to 48 hours at a pH from 6.5 to 8.0, whereby hepatitis virus present in said solution is inactivated, and then recovering at least one member from said solution.
Claim 5
Independent Claim
154 words
A method for making a hepatitis-safe preparation of at least one member selected from the group consisting of coagulation factors II, VIII, XIII, antithrombin III, and plasminogen, which method comprises first stabilizing against heat an aqueous solution containing at least one of said members by adding to said solution from 1.0 to 3.0 mols per liter of at least one amino acid selected from the group consisting of glycine, α- and β-alanine, hydroxyproline, glutamine, and α-, β-, and γ-aminobutyric acid and from 20 to 60 w/w percent of a carbohydrate selected from the group consisting of monosaccharides, oligosaccharides, and sugar alcohols, then heating the resulting heat-stabilized aqueous solution at a temperature from 30° C. to 100° C. for a period of time from one minute to 48 hours at a pH from 6.5 to 8.0, whereby hepatitis virus present in said solution is inactivated, and then recovering at least one member from said solution.
Claim 6
Dependent Claim
35 words
A method as in claim 3 wherein said amino acid is glycine, said carbohydrate is saccharose, and said heat-stabilized solution is heated at a temperature from 60° C. to 100° C. for approximately 10 hours.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-26 | 1985-04-27 | 1985-10-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-26 | 1989-04-27 | 1989-10-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-26 | 1993-04-27 | 1993-10-27 | $7700.00 | Window Closed / Lapsed |