US3732146A
Expired / Lapsed
US
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Process for the isolation of native, highly purified plasminogen
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1970-12-22
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Granted: 1973-05-08
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Expires: 1990-12-22
Abstract
Abstract Method for isolating native plasminogen in highly purified form from plasma or serum by contacting the plasminogen-containing material with a water-insoluble carrier containing an Epsilon amino carboxylic acid and then eluting the carrier to recover plasminogen bound thereto.
Inventors
- 👤 N Heimburger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 10:14
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/6435; C12Y; C12Y304/00; C12Y304/21; C12Y304/21007; Y; Y10; Y10S; Y10S435/00; Y10S435/814; Y10S435/815
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
23 words
A method as in claim 1 wherein said copolymer is a copolymer of maleic acid anhydride and said comonomer in a 1:1 ratio.
Claim 2
Dependent Claim
18 words
A method as in claim 1 wherein said copolymer is a copolymer of maleic acid anhydride and propylene.
Claim 3
Dependent Claim
22 words
A method as in claim 3 wherein said copolymer is a copolymer of maleic acid anhydride and propylene in a 1:1 ratio.
Claim 4
Dependent Claim
20 words
A method as in claim 1 wherein said epsilon -aminocarboxylic acid is epsilon -amino-caproic acid, 4-aminomethylbenzoic acid, or 4-aminomethylcyclohexane-carboxylic acid.
Claim 5
Dependent Claim
21 words
A method as in claim 1 wherein said copolymer is a copolymer of maleic acid anhydride and styrene cross-linked with divinylbenzene.
Claim 6
Dependent Claim
16 words
A method as in claim 1 wherein said copolymer is cross-linked by reaction with a diamine.
Claim 7
Dependent Claim
18 words
A method as in claim 7 wherein said diamine is pentamethylene diamine, hexamethylene diamine, or a phenylene diamine.
Claim 8
Dependent Claim
23 words
A method as in claim 1 wherein said eluted plasminogen is enriched by precipitation with ammonium sulfate and is then de-salted and dried.
Claim 9
Dependent Claim
14 words
A method as in claim 9 wherein said enriched plasminogen is desalted by dialysis.
Claim 10
Dependent Claim
14 words
A method as in claim 9 wherein said enriched plasminogen is dried by freeze-drying.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-05-07 | 1976-11-06 | 1977-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-05-07 | 1980-11-06 | 1981-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-05-07 | 1984-11-06 | 1985-05-08 | $7700.00 | Window Closed / Lapsed |