Colloidal compositions with protective agents suitable for radioactive labeling

Claim 2

In a process wherein a dispersion of colloidal sulfur particles to which stannous ions are attached suitable for radioactive labeling and use a diagnostic agent is prepared and lyophilized and where the physical and chemical properties of said particles degrade during lyophilization or aging thereafter, the improvement comprising additionally including in said dispersion in a sufficient amount an amino acid as a protective agent to reduce degradation of the physical and chemical properties of the dispersion during lyophilization and aging thereafter.

Claim 3

A process according to claim 1 wherein said amino acid is an aliphatic amino acid.

Claim 4

A process according to claim 2 wherein said amino acid is glycine.

Claim 5

A lyophilized product prepared by the process of claim 1.

Claim 6

A lyophilized product prepared by the process of claim 2.

Claim 7

A lyophilized product prepared by the process of claim 3.

Claim 8

An injectable radiopharmaceutical scanning agent prepared by radioactively labeling a product prepared by the process of claim 1.

Claim 9

An injectable radiopharmaceutical scanning agent prepared by radioactively labeling the product prepared by the process of claim 2.

Claim 10

An injectable radiopharmaceutical scanning agent prepared by radioactively labeling the product prepared by the process of claim 3.

Claim 11

In a process wherein a radiopharmaceutical scanning agent is injected and thereafter a scan made the improvement comprising utilizing as the scanning agent the agent of claim 7.

Claim 12

In a process wherein a radiopharmaceutical scanning agent is injected and thereafter a scan made the improvement comprising utilizing as a scanning agent the agent of claim 8.

Claim 13

In a process wherein a radiopharmaceutical scanning agent is injected and thereafter a scan made the improvement comprising utilizing as a scanning agent the agent of claim 9.

Claim 14

In a process wherein a dispersion of denatured aggregates of serum albumin to which tin is attached, suitable for radioactive labeling and use as a diagnostic agent is prepared and lyophilized and where the physical and chemical properties of said particles degrade during lyophilization or aging thereafter the improvement comprising additionally including in a sufficient amount in said dispersion as a protective agent a mixture of a polycarboxylic acid and a disaccharide or monosaccharide.

Claim 15

In a process wherein a dispersion of denatured aggregates of serum albumin to which tin is attached, suitable for radioactive labeling and use as a diagnostic agent is prepared and lyophilized and where the physical and chemical properties of said particles degrade during lyophilization or aging thereafter the improvement comprising additionally including in a sufficient amount in said dispersion as a protective agent a mixture of a polycarboxylic acid and a disaccharide or monosaccharide.

Claim 16

A process according to claim 13 wherein said protective agent is a mixture of a dicarboxylic acid containing 2 to 10 carbon atoms and a disaccharide.

Claim 17

A process according to claim 13 wherein said protective agent is a mixture of (1) lactose or dextrose and (2) succinic or glutaric acid.

Claim 18

A lyophilized product prepared by the process of claim 13.

Claim 19

A lyophilized product prepared by the process of claim 14.

Claim 20

A lyophilized product prepared by the process of claim 15.

Claim 21

An injectable radiopharmaceutical scanning agent prepared by radioactively labeling a product prepared by the process of claim 13.

Claim 22

An injectable radiopharmaceutical scanning agent prepared by radioactively labeling a product prepared by the process of claim 14.

Claim 23

An injectable radiopharmaceutical scanning agent prepared by radioactively labeling a product pepared by the process of claim 15.

Claim 24

In a process wherein a radiopharmaceutical scanning agent is injected and thereafter a scan made, the improvement comprising utilizing as a scanning agent the agent of claim 19.

Claim 25

In a process wherein a radiopharmaceutical scanning agent is injected and thereafter a scan made the improvement comprising ultilizing as the scanning agent the agent of claim 20.

Claim 26

In a process wherein a radiopharmaceutical scanning agent is injected and thereafter a scan made the improvement comprising utilizing as the scanning agent the agent of claim 21.

Claim 27

In a process wherein a dispersion of colloidal particles suitable for radioactive labeling and use as a diagnostic agent is prepared by (a) forming a dispersion containing a sulfur colloid by reacting in an aqueous medium a thiosulfate with a pharmaceutically acceptable acid (b) interacting a pharmaceutically acceptable stannous salt with the dispersion of (a), thereafter buffering the resulting dispersion, and (c) lyophilizing said dispersion and where the physical and chemical properties degrade during lyophilization or aging thereafter, the improvement comprising additionally including in said dispersion in a sufficient amount an amino acid as a protective agent to reduce degradation of the physical and chemical properties of the dispersion during lyophilization and aging thereafter.

Claim 28

In a process wherein a dispersion of colloidal particles suitable for radioactive labeling and use as a diagnostic agent is prepared by (a) forming a dispersion containing a sulfur colloid by reacting in an aqueous medium a thiosulfate with a pharmaceutically acceptable acid (b) interacting a pharmaceutically acceptable stannous salt with the dispersion of (a), thereafter buffering the resulting dispersion, and (c) lyophilizing said dispersion and where the physical and chemical properties degrade during lyophilization or aging thereafter, the improvement comprising additionally including in said dispersion in a sufficient amount an amino acid as a protective agent to reduce degradation of the physical and chemical properties of the dispersion during lyophilization and aging thereafter.

Claim 29

A lyophilized product prepared by the process of claim 25.

Claim 30

An injectable radiopharmaceutical scanning agent prepared by radioactively labelling a product prepared the process of claim 25.

Claim 31

In a process wherein a radiopharmaceutical scanning agent is injected and thereafter a scan made the improvement comprising utilizing as the scanning agent the agent of claim 27.