US3683066A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Technetium 99m colloidal composition
Assignee: GERALD A BRUNO
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Filing: 1969-01-14
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Granted: 1972-08-08
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Expires: 1989-01-14
Abstract
Abstract Disclosed herein is a sterile nonpyrogenic composition and method for preparing Technetium 99m sulfur colloid containing a chelating agent utilized in the scanning of liver and other organs of the body.
Inventors
- 👤 Ivan Ascanio
- 👤 Thomas A Haney
- 👤 Gerald A Bruno
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 08:43
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; C; C01; C01G; C01G99/00; C01G99/006; A61K2123/00; Y; Y10; Y10S; Y10S424/00; Y10S424/06
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
48 words
A kit in accordance with claim 1 wherein the chelating agent is selected from the group consisting of: (((1,2-cyclohexylene)oxyethylene)dinitrillo)-tetraacetic acid; (oxybis(ethylenenitrilo))tetraacetic acid; (1,2-cyclohexylenedinitrilo)tetraacetic acid; N-(5-(3-((5-aminopentyl)hydroxycarbamoyl)propionamido)pentyl)-3-((5-(N -hydroxyacetamido)pentyl)carbamoyl)propionhydroxamic acid; diethyldithiocarbamic acid sodium salt; (diethylenetrinitrilo)-pentaacetic acid; (diethylenetrinitrilo)pentaacetic acid pentaethyl ester; (ethylenedinitrilo)tetraacetic acid; ((2-(3-oxomorpholino)ethyl)imino)diacetic acid, diethyl ester; disodium edetate and ((2-mercaptoethyl)imino)diacetic acid.
Claim 2
Dependent Claim
38 words
In a process for preparing a Technetium 99m sulfur colloid which comprises reacting sodium thiosulfate with an acid in the presence of a gelling agent, the improvement wherein a chelating agent is included in order to prevent flocculation.
Claim 3
Dependent Claim
46 words
A process in accordance with claim 3 wherein the chelating agent is selected from the group consisting of (((1,2-cyclohexylene)oxyethylene)dinitrillo)tetraacetic acid; (oxybis(ethylenenitrilo))tetraacetic acid; (1,2-cyclohexylenedinitrilo)tetraacetic acid; N-(5-(3-((5-aminopentyl)-hydroxycarbamoyl)propionamido)pentyl)-3-((5-(N -hydroxyacetamido)-pentyl)carbamoyl)propionhydroxamic acid; diethyldithiocarbamic acid sodium salt; (diethylenetrinitrilo)pentaacetic acid; (diethylenetrinitrilo)pentaacetic acid pentaethyl ester; (ethylenedinitrilo)-tetraacetic acid; ((2-(3-oxomorpholino)ethyl)imino)diacetic acid, diethyl ester; and ((2-mercaptoethyl)imino)diacetic acid.
Claim 4
Dependent Claim
23 words
A process in accordance with claim 3 wherein the chelating agent is present in about 0.09 to 1.0 percent of the total solution.
Claim 5
Dependent Claim
24 words
A kit in accordance with claim 2 wherein the chelating agent is present in about 0.09 to about 1.0 percent of the total solution.
References Cited (Backward Citations)
US3466361A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-08-08 | 1976-02-07 | 1976-08-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-08-08 | 1980-02-07 | 1980-08-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-08-08 | 1984-02-07 | 1984-08-08 | $7700.00 | Window Closed / Lapsed |