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US4460565A Expired / Lapsed US ⏱️ 0.0 years remaining

Anticariogenic remineralizing dentifrice

Assignee: INTRADAL NEDERLAND
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Filing: 1982-07-02
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Granted: 1984-07-17
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Expires: 2002-07-02
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Abstract

Abstract A dentifrice containing two or more fluorine compounds, at least one soluble salt producing phosphate ions, and at least one substance providing calcium ions, and as a result thereof having good remineralization properties. Preferred compositions contain as the fluorine compounds a fluoride and a monofluorophosphate, as phosphate compounds a cyclic metaphosphate and a linear phosphate, and as calcium compound a calcium salt of an organic acid.

Inventors

  • 👤 Jan Weststrate
  • 👤 Ede M. Staal

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-29 04:05
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/20; A61K8/21; A61K8/24; A61Q; A61Q11/00; A61K2800/00; A61K2800/80; A61K2800/88

Claims Analysis

Total Claims: 20
Claim 1
Independent Claim 133 words
A dentifrice having anticariogenic and remineralizing properties, comprising: (a) a fluoride selected from the group consisting of alkali metal fluorides, alkaline earth metal fluorides, and ammonium fluoride; (b) an alkali metal fluorophosphate; (c) a soluble cyclic alkali metal phosphate; (d) a soluble linear phosphate; and (e) a calcium containing substance, selected from the group consisting of calcium citrate and calcium tartrate, and wherein the concentration of components (a)+(b), calculated as F, is 250-500 ppm in a mouth wash, 1000-1500 ppm in a toothpaste, 5000-7500 ppm in a prophylactic paste, and 10,000-15,000 ppm in an application liquid or gel; the concentration of component (c) is 0.1-5% by weight; the concentration of component (e) is 0.05-5% by weight; and the concentration of component (d) is such to provide a Ca:P atomic ratio of about 1.66:1.
Claim 2
Dependent Claim 133 words
A dentifrice having anticariogenic and remineralizing properties, comprising: (a) a fluoride selected from the group consisting of alkali metal fluorides, alkaline earth metal fluorides, and ammonium fluoride; (b) an alkali metal fluorophosphate; (c) a soluble cyclic alkali metal phosphate; (d) a soluble linear phosphate; and (e) a calcium containing substance, selected from the group consisting of calcium citrate and calcium tartrate, and wherein the concentration of components (a)+(b), calculated as F, is 250-500 ppm in a mouth wash, 1000-1500 ppm in a toothpaste, 5000-7500 ppm in a prophylactic paste, and 10,000-15,000 ppm in an application liquid or gel; the concentration of component (c) is 0.1-5% by weight; the concentration of component (e) is 0.05-5% by weight; and the concentration of component (d) is such to provide a Ca:P atomic ratio of about 1.66:1.
Claim 3
Dependent Claim 70 words
A dentifrice according to claim 1, wherein said fluoride (a) is sodium fluoride; said fluorophosphate (b) is sodium monofluorophosphate; said cyclic phosphate (c) is sodium trimetaphosphate; said linear phosphate (d) is at least one of phosphoric acid, sodium orthophosphate, sodium tripolyphosphate, sodium tetrapolyphosphate, sodium pyrophosphate, and sodium hexametaphosphate; and said calcium containing substance (e) is at least one of calcium citrate, calcium tartrate, calcium adipate, calcium zeolite, and calcium apofyllite.
Claim 4
Dependent Claim 34 words
A dentifrice according to claim 2, wherein said linear phosphate (d) is phosphoric acid, sodium orthophosphte or phosphoric acid plus sodium orthophosphate, and said calcium containing substance (e) is calcium citrate or calcium tartrate.
Claim 5
Dependent Claim 21 words
A dentifrice according to claim 1 wherein the ratio of component (a) to component (b), calculated as F, is about 3:1.
Claim 6
Dependent Claim 21 words
A dentifrice according to claim 2 wherein the ratio of component (a) to component (b), calculated as F, is about 3:1.
Claim 7
Dependent Claim 21 words
A dentifrice according to claim 3 wherein the ratio of component (a) to component (b), calculated as F, is about 3:1.
Claim 8
Dependent Claim 21 words
A dentifrice according to claim 1 wherein the ratio of component (a) to component (b), calculated as F, is about 3:1.
Claim 9
Dependent Claim 11 words
A dentifrice according to claim 7 which is a mouth wash.
Claim 10
Dependent Claim 10 words
A dentifrice according to claim 7 which is a toothpaste.
Claim 11
Dependent Claim 11 words
A dentifrice according to claim 7 which is a prophylactic paste.
Claim 12
Dependent Claim 13 words
A dentifrice according to claim 7 which is an application liquid or gel.
Claim 13
Dependent Claim 44 words
A toothpaste according to claim 1 comprising 0.22% by weight of sodium fluoride, 0.36% by weight of sodium monofluorophosphte, 0.40% by weight of sodium orthophosphate, 0.30% by weight of phosphoric acid, 0.25% by weight of sodium trimetaphosphate, and 0.6% by weight of calcium citrate.
Claim 14
Dependent Claim 66 words
A dentifrice according to claim 1 which is a toothpaste having the formulation in parts by weight: ______________________________________ Aluminum oxide 35.0 silicon oxide 2.0 glycerol 20.0 carboxymethyl cellulose 1.5 sodium lauryl sulphate 2.0 peppermint oil 1.0 sodium saccharinate 0.2 sodium fluoride 0.22 sodium monofluorophosphate 0.36 primary sodium phosphate 0.40 phosphoric acid 0.30 sodium trimetaphosphate 0.25 calcium citrate 0.6 Na--methyl p-hydroxybenzoate 0.10 water to make 100. ______________________________________
Claim 15
Dependent Claim 15 words
A dentifrice according to claim 1 wherein said fluoride (a) is an alkali metal fluoride.
Claim 16
Dependent Claim 14 words
A dentifrice according to claim 14 wherein said alkali metal fluoride is sodium fluoride.
Claim 17
Dependent Claim 15 words
A dentifrice according to claim 1 wherein said alkali metal fluorophosphate (b) is sodium fluorophosphate.
Claim 18
Dependent Claim 15 words
A dentifrice according to claim 1 wherein said cyclic alkali metal phosphate is sodium trimetaphosphate.
Claim 19
Dependent Claim 36 words
A dentifrice according to claim 1 wherein said soluble linear phosphate is selected from the group consisting of phosphoric acid, alkali metal orthophosphates, alkali metal tripolyphosphates, alkali metal tetrapolyphosphates, alkali metal pyrrophosphates, and alkali metal hexametaphosphates.
Claim 20
Dependent Claim 23 words
A dentifrice according to claim 18 wherein said soluble linear phosphate is selected from the group consisting of phosphoric acid and sodium orthophosphate.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1987-07-17 1988-01-16 1988-07-17 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1991-07-17 1992-01-16 1992-07-17 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1995-07-17 1996-01-16 1996-07-17 $7700.00 Window Closed / Lapsed

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