US4358437A
Expired / Lapsed
US
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Compositions
Assignee: Beecham Group PLC
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Filing: 1981-04-13
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Granted: 1982-11-09
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Expires: 2001-04-13
Abstract
Abstract A toothpaste contains 2% by weight of calcium metasilicate, 0.80% of sodium monofluorophosphate and 44.77% calcium carbonate. The presence of calcium metasilicate in combination with the monofluorophosphate and carbonate increases the fluoride uptake over and above that which is expected from the level of free fluoride present.
Inventors
- 👤 Susan A. Duke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 22:47
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/24; A61K8/25
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
85 words
An anticariogenic oral hygiene composition substantially free of alumina and having improved fluoride release from monofluorophosphate, comprising a source of monofluorophosphate ions, a source of carbonate ions and a source of metasilicate ions, each source being present in an amount such that, in use, an aqueous solution containing from 3.5 to 7.0×10 -4 mol.l -1 dissolved metasilicate ions, from 1 to 2×10 -2 mol.l -1 dissolved monofluorophosphate ions and from 0.5×10 -4 to 1×10 -3 mol.l -1 dissolved carbonate ions is produced in the mouth.
Claim 2
Dependent Claim
85 words
An anticariogenic oral hygiene composition substantially free of alumina and having improved fluoride release from monofluorophosphate, comprising a source of monofluorophosphate ions, a source of carbonate ions and a source of metasilicate ions, each source being present in an amount such that, in use, an aqueous solution containing from 3.5 to 7.0×10 -4 mol.l -1 dissolved metasilicate ions, from 1 to 2×10 -2 mol.l -1 dissolved monofluorophosphate ions and from 0.5×10 -4 to 1×10 -3 mol.l -1 dissolved carbonate ions is produced in the mouth.
Claim 3
Dependent Claim
23 words
An anticariogenic oral hygiene composition according to claim 1, in which the concentration of metasilicate ions is about 5×10 -4 mol.l -1 .
Claim 4
Dependent Claim
17 words
An anticariogenic oral hygiene composition according to claim 1 in which the metasilicate source is calcium metasilicate.
Claim 5
Dependent Claim
67 words
An anticariogenic toothpaste, substantially free of alumina, comprising a source of monofluorophosphate ions, a source of carbonate ions and a source of metasilicate ions in an aqueous toothpaste vehicle, in which the ionic concentrations of dissolved monofluorophosphate, carbonate and metasilicate ions are from 4 to 8×10 -2 mol.l -1 , from 2×10 -4 to 4×10 -3 mol.l -1 and from 1.5 to 3×10 -3 mol.l -1 respectively.
Claim 6
Dependent Claim
67 words
An anticariogenic toothpaste, substantially free of alumina, comprising a source of monofluorophosphate ions, a source of carbonate ions and a source of metasilicate ions in an aqueous toothpaste vehicle, in which the ionic concentrations of dissolved monofluorophosphate, carbonate and metasilicate ions are from 4 to 8×10 -2 mol.l -1 , from 2×10 -4 to 4×10 -3 mol.l -1 and from 1.5 to 3×10 -3 mol.l -1 respectively.
Claim 7
Dependent Claim
22 words
An anticariogenic toothpaste according to claim 4, in which not more than 6×10 -2 mol.l -1 of dissolved monofluorophosphate ions are present.
Claim 8
Dependent Claim
23 words
An anticariogenic toothpaste according to claim 4, in which from 5×10 -4 to 10×10 -4 mol.l -1 of dissolved carbonate ions are present.
Claim 9
Dependent Claim
42 words
An anticariogenic toothpaste according to claim 4, comprising from 1.2 to 3.5% by weight of calcium metasilicate, from 10 to 60% by weight of calcium carbonate, and from 0.6 to 1.2% by weight of an ionic monofluorophosphate, in an aqueous toothpaste vehicle.
Claim 10
Dependent Claim
16 words
An anticariogenic toothpaste according to claim 7 which contains about 2% by weight of calcium metasilicate.
Claim 11
Dependent Claim
37 words
A method of increasing the fluoride uptake by tooth enamel, which method comprises treating teeth with an anticariogenic, oral-hygiene composition according to claim 1, in about a fourfold amount prior to dilution by saliva in the mouth.
Claim 12
Dependent Claim
27 words
An anticariogenic toothpaste according to claim 4, in which the ionic sources are present in about a fourfold amount before dilution by the saliva of the mouth.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-08 | 1986-05-10 | 1986-11-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-08 | 1990-05-10 | 1990-11-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-08 | 1994-05-10 | 1994-11-09 | $7700.00 | Window Closed / Lapsed |