US4432996A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hypocholesterolemic fermentation products and process of preparation
Assignee: Merck and Co Inc
•
Filing: 1982-05-17
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Granted: 1984-02-21
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Expires: 2002-05-17
Abstract
Abstract Substances isolated after cultivation of a micoorganism belonging to the genus Penicillium in a culture medium comprises compounds which have strucures: <IMAGE> I <IMAGE> II Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesterolemic and hypolipemic medicaments.
Inventors
- 👤 Vincent P. Gullo
- 👤 Tony Y. K. Lam
- 👤 Richard L. Monaghan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 05:45
CPC Classifications
C; C12; C12N; C12N1/00; C12N1/14; C12N1/145; C07; C07D; C07D309/00; C07D309/16; C07D309/28; C07D309/30; C12P; C12P17/00; C12P17/02; C12P17/06; C12P7/00; C12P7/62; C12R; C12R2001/00; C12R2001/645; C12R2001/80
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
27 words
The compound: ##STR6## or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
Claim 2
Dependent Claim
27 words
The compound: ##STR6## or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
Claim 3
Dependent Claim
23 words
The pharmaceutically acceptable salts of the compound of claim 1, wherein the cation is derived from ammonia, ethylenediamine, N-methylglucamine, lysine, arginine or ornithine.
Claim 4
Dependent Claim
9 words
The ammonium salt of Compound II of claim 1.
Claim 5
Dependent Claim
9 words
The ethylenediamine salt of Compound II of claim 1.
Claim 6
Dependent Claim
16 words
The lower alkyl esters and substituted lower alkyl esters of the compound II of claim 1.
Claim 7
Dependent Claim
9 words
The ethyl ester of Compound II of claim 1.
Claim 8
Dependent Claim
41 words
An antihypercholesterolemic pharmaceutical composition comprising a pharmaceutical carrier and an effective antihypercholesterolemic amount of the compound: ##STR7## or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
Claim 9
Dependent Claim
41 words
An antihypercholesterolemic pharmaceutical composition comprising a pharmaceutical carrier and an effective antihypercholesterolemic amount of the compound: ##STR7## or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
Claim 10
Dependent Claim
26 words
The composition of claim 7 wherein the compound is a pharmaceutically acceptable salt wherein the cation is derived from ammonia, ethylenediamine, N-methylglucamine, lysine, arginine or ornithine.
Claim 11
Dependent Claim
15 words
The composition of claim 7 wherein the compound is the ammonium salt of Compound II.
Claim 12
Dependent Claim
15 words
The composition of claim 7 wherein the compound is the ethylenediamine salt of Compound II.
Claim 13
Dependent Claim
21 words
The composition of claim 7 wherein the compound is a lower alkyl ester or substituted lower aklyl ester of Compound II.
Claim 14
Dependent Claim
15 words
The composition of claim 7 wherein the compound is the ethyl ester of Compound II.
References Cited (Backward Citations)
US3983140A
Cited
US4049495A
Cited
US4137322A
Cited
US4231938A
Cited
US4319039A
Cited
EP0033538A2
Cited
US4293496A
Cited
US4346227A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-20 | 1987-08-22 | 1988-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-20 | 1991-08-22 | 1992-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-20 | 1995-08-22 | 1996-02-21 | $7700.00 | Window Closed / Lapsed |