US4137322A
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US
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ML-236B carboxylic acid derivatives and their use as antihyperlipemic agents
Assignee: Sankyo Co Ltd
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Filing: 1977-10-31
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Granted: 1979-01-30
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Expires: 1997-10-31
Abstract
Abstract ML-236B carboxylic acid derivatives having the formula ##STR1## wherein R represents an alkyl group, a benzyl group optionally substituted with alkyl, alkoxy or halogen or a phenacyl group optionally substituted with alkyl, alkoxy or halogen; a group of 1/n M in which M represents a metal and n represents a valency of said metal; or a group of AH + in which A represents an amino acid. These derivatives are derived from ML-236B by conventional procedures and have an antihyperlipemic activity.
Inventors
- 👤 Akira Endo
- 👤 Akira Terahara
- 👤 Noritoshi Kitano
- 👤 Akira Ogiso
- 👤 Seiji Mitsui
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 16:18
CPC Classifications
C; C07; C07F; C07F3/00; C07F3/003; C07F1/00; C07F1/005; C07F5/00; C07F5/06; C07F5/069
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
65 words
A compound having the formula ##STR4## wherein R represents an alkyl group, a benzyl group optionally substituted with alkyl, alkoxy or halogen or a phenacyl group optionally substituted with alkyl, alkoxy or halogen; a group of 1/n M in which M represents a metal and n represents a valency of said metal; or a group of AH + in which A represents an amino acid.
Claim 2
Dependent Claim
65 words
A compound having the formula ##STR4## wherein R represents an alkyl group, a benzyl group optionally substituted with alkyl, alkoxy or halogen or a phenacyl group optionally substituted with alkyl, alkoxy or halogen; a group of 1/n M in which M represents a metal and n represents a valency of said metal; or a group of AH + in which A represents an amino acid.
Claim 3
Dependent Claim
33 words
A compound according to claim 1 wherein R is an alkyl group, a benzyl group optionally substituted with alkyl, alkoxy or halogen or a phenacyl group optionally substituted with alkyl, alkoxy or halogen.
Claim 4
Dependent Claim
55 words
A compound according to claim 2 wherein R is an alkyl group of 1 to 6 carbon atoms, a benzyl group optionally substituted with C 1 -C 2 alkyl, C 1 -C 2 alkoxy or halogen or a phenacyl group optionally substituted with C 1 -C 2 alkyl, C 1 -C 2 alkoxy or halogen.
Claim 5
Dependent Claim
26 words
A compound according to claim 2 wherein R is a methyl, ethyl, n-propyl, isopropyl, n-butyl, n-hexyl, benzyl, 4-methylbenzyl, 4-methoxybenzyl, 4-chlorobenzyl, phenacyl, 4-methylphenacyl, 4-methoxyphenacyl or 4-bromophenacyl group.
Claim 6
Dependent Claim
28 words
A compound according to claim 1 wherein R is a group of 1/n M in which M represents a metal and n is a valency of said metal.
Claim 7
Dependent Claim
13 words
A compound according to claim 5 wherein said metal is an alkali metal.
Claim 8
Dependent Claim
14 words
A compound according to claim 5 wherein said metal is an alkaline earth metal.
Claim 9
Dependent Claim
11 words
A compound according to claim 5 wherein said metal is aluminum.
Claim 10
Dependent Claim
13 words
A compound according to claim 5 wherein said metal is sodium or calcium.
Claim 11
Dependent Claim
21 words
A compound according to claim 1 wherein R is a group of AH + in which A is an amino acid.
Claim 12
Dependent Claim
15 words
A compound according to claim 10 wherein said amino acid is a basic amino acid.
Claim 13
Dependent Claim
18 words
A compound according to claim 10 wherein said amino acid is arginine, lysine, histidine, α,γ-diaminobutyric acid or ornithine.
Claim 14
Dependent Claim
83 words
A composition for the treatment of hyperlipemia which comprises as an active ingredient a compound of the formula ##STR5## wherein R represents an alkyl group, a benzyl group optionally substituted with alkyl, alkoxy or halogen or a phenacyl group optionally substituted with alkyl, alkoxy or halogen; a group of 1/n M in which M represents a metal and n represents a valency of said metal; or a group of AH + in which A represents an amino acid and a pharmaceutically acceptable carrier.
Claim 15
Dependent Claim
83 words
A composition for the treatment of hyperlipemia which comprises as an active ingredient a compound of the formula ##STR5## wherein R represents an alkyl group, a benzyl group optionally substituted with alkyl, alkoxy or halogen or a phenacyl group optionally substituted with alkyl, alkoxy or halogen; a group of 1/n M in which M represents a metal and n represents a valency of said metal; or a group of AH + in which A represents an amino acid and a pharmaceutically acceptable carrier.
Claim 16
Dependent Claim
33 words
A composition according to claim 13 wherein R is an alkyl group, a benzyl group optionally substituted with alkyl, alkoxy or halogen or a phenacyl group optionally substituted with alkyl, alkoxy or halogen.
Claim 17
Dependent Claim
28 words
A composition according to claim 13 wherein R is a group of 1/n M in which M represents a metal and n is a valency of said metal.
Claim 18
Dependent Claim
21 words
A composition according to claim 13 wherein R is a group of AH + in which A is an amino acid.
References Cited (Backward Citations)
US3983140A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-29 | 1982-07-31 | 1983-01-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-29 | 1986-07-31 | 1987-01-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-29 | 1990-07-31 | 1991-01-30 | $7700.00 | Window Closed / Lapsed |