US4049495A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Physiologically active substances and fermentative process for producing the same
Assignee: Sankyo Co Ltd
•
Filing: 1975-12-04
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Granted: 1977-09-20
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Expires: 1995-12-04
Abstract
Abstract Physiologically active substances ML-236 of the formula ##STR1## wherein R is hydrogen atom, hydroxy group or 2-methyl-butyryloxy group having cholesterol- and lipid-lowering effects in blood and liver and thus utility as hypocholesteremic and hypolipemic medicaments. They are obtained by cultivation of an ML-236-producing micro-organism belonging to the genus Penicillium in a culture medium and subsequent recovery thereof from a cultured broth.
Inventors
- 👤 Akira Endo
- 👤 Masao Kuroda
- 👤 Akira Terahara
- 👤 Yoshio Tsujita
- 👤 Chihiro Tamura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:33
CPC Classifications
C; C12; C12P; C12P17/00; C12P17/02; C12P17/06; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/911; Y10S435/933
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
43 words
A process for the production of substances, ML-236A, ML-236B and ML-236C having the formulae, respectively, ##STR4## which comprises cultivating an ML-236-producing microorganism belonging to the genus Penicillium in a culture medium under aerobic condition and recovering said ML-236 substances from the cultured broth.
Claim 2
Dependent Claim
43 words
A process for the production of substances, ML-236A, ML-236B and ML-236C having the formulae, respectively, ##STR4## which comprises cultivating an ML-236-producing microorganism belonging to the genus Penicillium in a culture medium under aerobic condition and recovering said ML-236 substances from the cultured broth.
Claim 3
Dependent Claim
14 words
A process according to claim 1 wherein said microorganism is Penicillium citrinum SANK 18767.
Claim 4
Dependent Claim
21 words
A process according to claim 1 wherein said cultivation is effected at a temperature ranging from 20° C. to 30° C.
Claim 5
Dependent Claim
21 words
A process according to claim 1 wherein the pH of said culture medium is within a range of 3 to 9.
Claim 6
Dependent Claim
19 words
A process according to claim 1 wherein cultivation period is within a range of 20 hours to 240 hours.
References Cited (Backward Citations)
US3297526A
Cited
US3909362A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-09-19 | 1981-03-21 | 1981-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-09-19 | 1985-03-21 | 1985-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-09-19 | 1989-03-21 | 1989-09-20 | $7700.00 | Window Closed / Lapsed |