Patent US4430333A successfully refreshed from Google Patents.
US4430333A
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Dihydropyridine anti-ischaemic and antihypertensive agents
Assignee: Pfizer Inc
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Filing: 1982-03-11
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Granted: 1984-02-07
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Expires: 2002-03-11
Abstract
Abstract Dihydropyridine anti-ischaemic and antihypertensive agents of the formula: <IMAGE> (I) where Y is -(CH2)2- or -(CH2)3-; R is aryl or heteroaryl; R1 and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; and R3 and R4 are each independently C1-C4 alkyl or aryl-(C1-C4 alkyl); or R3 and R4 taken together with the nitrogen atom to which they are attached represent a group of the formula: <IMAGE> where R5 is C1-C4 alkyl, aryl, aryl-(C1-C4 alkyl), benzhydryl; 2-methoxyethyl, 2-(N,N-di[C1-C4 alkyl]amino) ethyl, or cyclopropylmethyl; their pharmaceutically acceptable acid addition salts, processes for the preparation of the compounds, and pharmaceutical compositions containing them.
Inventors
- 👤 Simon F. Campbell
- 👤 Peter E. Cross
- 👤 John K. Stubbs
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:47
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/54; C07D213/55; C07D401/00; C07D401/02; C07D401/04; A; A61; A61P; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P9/12; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/90; C07D409/00; C07D409/02; C07D409/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
100 words
A compound of the formula ##STR68## or a pharmaceutically acceptable acid addition salt thereof, wherein Y is --(CH 2 ) 2 -- or --(CH 2 ) 3 --; R is aryl; R 1 and R 2 are each independently C 1 -C 4 alkyl or 2-methoxyethyl; and R 3 and R 4 are each independently C 1 -C 4 alkyl or aryl-(C 1 -C 4 alkyl); wherein said aryl is phenyl; phenyl substituted by one or two substituents selected from nitro, halo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, trifluoromethyl, and cyano; or is 1- or 2-naphthyl.
Claim 2
Dependent Claim
100 words
A compound of the formula ##STR68## or a pharmaceutically acceptable acid addition salt thereof, wherein Y is --(CH 2 ) 2 -- or --(CH 2 ) 3 --; R is aryl; R 1 and R 2 are each independently C 1 -C 4 alkyl or 2-methoxyethyl; and R 3 and R 4 are each independently C 1 -C 4 alkyl or aryl-(C 1 -C 4 alkyl); wherein said aryl is phenyl; phenyl substituted by one or two substituents selected from nitro, halo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, trifluoromethyl, and cyano; or is 1- or 2-naphthyl.
Claim 3
Dependent Claim
50 words
A compound of claim 1 wherein R is 1-naphthyl; phenyl; or phenyl monosubstituted by halo, trifluoromethyl, cyano or nitro; and R 3 and R 4 are each independently C 1 -C 4 alkyl, or benzyl optionally monosubstituted on the aromatic ring portion by halo or C 1 -C 4 alkoxy.
Claim 4
Dependent Claim
38 words
A compound of claim 2 wherein Y is (CH 2 ) 2 ; R is 1-naphthyl or 2-chlorophenyl; R 1 and R 2 are each independently methyl or ethyl; and R 3 and R 4 are both methyl.
Claim 5
Dependent Claim
18 words
A compound of claim 3 wherein R is 2-chlorophenyl, R 1 is methyl and R 2 is ethyl.
Claim 6
Dependent Claim
18 words
A compound of claim 3 wherein R is 1-naphthyl and R 1 and R 2 are each ethyl.
Claim 7
Dependent Claim
23 words
A pharmaceutical composition comprising an anti-ischaemic or antihypertensive effective amount of a compound of claim 1 and a pharmaceutically acceptable diluent or carrier.
Claim 8
Dependent Claim
39 words
A pharmaceutical composition of claim 6 wherein Y is (CH 2 ) 2 ; R is 1-naphthyl or 2-chlorophenyl; R 1 and R 2 are each independently methyl or ethyl; and R 3 and R 4 are both methyl.
Claim 9
Dependent Claim
27 words
A method of treating hypertension in an animal in need of treatment comprising administering to said animal an effective anti-hypertensive amount of a compound of claim 1.
Claim 10
Dependent Claim
27 words
A method of treating ischaemia in an animal in need of treatment comprising administering to said animal an effective anti-ischaemic amount of a compound of claim 1.
Claim 11
Dependent Claim
42 words
A method according to claim 8 or claim 9 wherein Y is (CH 2 ) 2 ; R is 1-naphthyl or 2-chlorophenyl; R 1 and R 2 are each independently methyl or ethyl; and R 3 and R 4 are both methyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-06 | 1987-08-08 | 1988-02-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-06 | 1991-08-08 | 1992-02-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-06 | 1995-08-08 | 1996-02-07 | $7700.00 | Window Closed / Lapsed |