US3946028A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
Assignee: Bayer AG
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Filing: 1974-11-15
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Granted: 1976-03-23
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Expires: 1994-11-15
Abstract
Abstract 1,4-Dihydropyridines bearing carboxy functions in the 3-, 5- and 6- or 2-, 3-, 5- and 6-positions and being substituted in the 4-position by phenyl, substituted phenyl, naphthyl, phenylalkyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethylester is a representative embodiment, are prepared through condensation of an enamine with an ylidene acid ester, the latter being separately prepared or prepared in situ.
Inventors
- 👤 Friedrich Bossert
- 👤 Horst Meyer
- 👤 Wulf Vater
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 17:47
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/12; C07D213/00; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/4422; C07D213/02; C07D213/04; C07D213/24; C07D213/54; C07D213/55; C07D401/04; C07D401/14
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
141 words
A compound of the formula: ##SPC53## or a pharmaceutically acceptable nontoxic salt thereof, wherein R is hydrogen, alkyl of up to 4 carbon atoms or alkenyl of up to 4 carbon atoms; R 2 is alkyl of up to 6 carbon atoms, alkenyl of up to 6 carbon atoms, said alkyl substituted by hydroxyl, said alkenyl substituted by hydroxyl, said alkyl interrupted by oxygen or said alkenyl interrupted by oxygen; R 3 is alkyl of up to 6 carbon atoms or alkenyl of up to 6 carbon atoms; R 5 is hydrogen or alkyl of 1 to 4 carbon atoms; n is 0, 1, 2 or 3; and X is pyridyl unsubstituted or substituted by one or two members selected from the group consisting of alkyl of up to 4 carbon atoms, alkoxy of up to 4 carbon atoms and halogeno.
Claim 2
Dependent Claim
141 words
A compound of the formula: ##SPC53## or a pharmaceutically acceptable nontoxic salt thereof, wherein R is hydrogen, alkyl of up to 4 carbon atoms or alkenyl of up to 4 carbon atoms; R 2 is alkyl of up to 6 carbon atoms, alkenyl of up to 6 carbon atoms, said alkyl substituted by hydroxyl, said alkenyl substituted by hydroxyl, said alkyl interrupted by oxygen or said alkenyl interrupted by oxygen; R 3 is alkyl of up to 6 carbon atoms or alkenyl of up to 6 carbon atoms; R 5 is hydrogen or alkyl of 1 to 4 carbon atoms; n is 0, 1, 2 or 3; and X is pyridyl unsubstituted or substituted by one or two members selected from the group consisting of alkyl of up to 4 carbon atoms, alkoxy of up to 4 carbon atoms and halogeno.
Claim 3
Dependent Claim
18 words
A compound according to claim 1 wherein R is hydrogen, and R 2 and R 3 are alkyl.
Claim 4
Dependent Claim
15 words
The compound according to claim 1 which is 4-(α-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester-2,6-diacetic acid diethyl ester.
Claim 5
Dependent Claim
15 words
The compound according to claim 1, which is 4-(β-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester-2,6-diacetic acid diethyl ester.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-03-23 | 1979-09-22 | 1980-03-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-03-23 | 1983-09-22 | 1984-03-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-03-23 | 1987-09-22 | 1988-03-23 | $7700.00 | Window Closed / Lapsed |