US3946027A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
Assignee: Bayer AG
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Filing: 1974-11-15
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Granted: 1976-03-23
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Expires: 1994-11-15
Abstract
Abstract 1,4-Dihydropyridines bearing carboxy functions in the 3-, 5- and 6- or 2-, 3-, 5- and 6-positions and being substituted in the 4-position by phenyl, substituted phenyl, naphthyl, phenylalkyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethylester is a representative embodiment, are prepared through condensation of an enamine with an ylidene acid ester, the latter being separately prepared or prepared in situ.
Inventors
- 👤 Friedrich Bossert
- 👤 Horst Meyer
- 👤 Wulf Vater
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:48
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/12; C07D213/00; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/4422; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/90; C07D213/02; C07D213/04; C07D213/24; C07D213/54; C07D213/55; C07D401/04; C07D401/14
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
151 words
A compound of the formula: ##SPC52## or a pharmaceutically acceptable non-toxic salt thereof, wherein R is hydrogen, alkyl of up to 4 carbon atoms or alkenyl of up to 4 carbon atoms; R 1 is hydrogen or alkyl of up to 4 carbon atoms; each of R 2 and R 3 , taken independently of the other, is alkyl of up to 4 carbon atoms, hydroxy alkyl of up to 4 carbon atoms, alkoxy alkyl of up to 4 carbon atoms, alkenyl of up to 4 carbon atoms or alkynyl of up to 4 carbon atoms; R 5 is hydrogen or alkyl of up to 4 carbon atoms; and X is pyridyl unsubstituted or substituted by one or two members selected from the group consisting of alkyl of up to 4 carbon atoms, alkoxy of up to 4 carbon atoms, and halogeno; and n has a value of 0 to 3.
Claim 2
Dependent Claim
151 words
A compound of the formula: ##SPC52## or a pharmaceutically acceptable non-toxic salt thereof, wherein R is hydrogen, alkyl of up to 4 carbon atoms or alkenyl of up to 4 carbon atoms; R 1 is hydrogen or alkyl of up to 4 carbon atoms; each of R 2 and R 3 , taken independently of the other, is alkyl of up to 4 carbon atoms, hydroxy alkyl of up to 4 carbon atoms, alkoxy alkyl of up to 4 carbon atoms, alkenyl of up to 4 carbon atoms or alkynyl of up to 4 carbon atoms; R 5 is hydrogen or alkyl of up to 4 carbon atoms; and X is pyridyl unsubstituted or substituted by one or two members selected from the group consisting of alkyl of up to 4 carbon atoms, alkoxy of up to 4 carbon atoms, and halogeno; and n has a value of 0 to 3.
Claim 3
Dependent Claim
17 words
A compound according to claim 1 wherein R 1 is alkyl of up to 4 carbon atoms.
Claim 4
Dependent Claim
36 words
A compound according to claim 2 wherein R is hydrogen, R 2 and R 3 are alkyl of up to 4 carbon atoms and R 5 is hydrogen or alkyl of up to 4 carbon atoms.
Claim 5
Dependent Claim
15 words
The compound according to claim 1 which is 2-methyl-4-(α-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester-6-acetic acid methyl ester.
Claim 6
Dependent Claim
13 words
The compound according to claim 1 which is 2-methyl-4-(α-pyridyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid 3-methyl ester-5,6-diethyl ester.
Claim 7
Dependent Claim
12 words
The compound according to claim 1 which is 2-methyl-4-(β-pyridyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester.
Claim 8
Dependent Claim
12 words
The compound according to claim 1 which is 2-methyl-4-(α-pyridyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester.
Claim 9
Dependent Claim
12 words
The compound according to claim 1 which is 2-methyl-4-(γ-pyridyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-03-23 | 1979-09-22 | 1980-03-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-03-23 | 1983-09-22 | 1984-03-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-03-23 | 1987-09-22 | 1988-03-23 | $7700.00 | Window Closed / Lapsed |