Patent US2798482A successfully refreshed from Google Patents.
Patent US4421735A successfully refreshed from Google Patents.
US4421735A
Expired / Lapsed
US
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Radiolabeled diagnostic compositions and method for making the same
Assignee: General Hospital Corp
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Filing: 1980-04-17
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Granted: 1983-12-20
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Expires: 2000-04-17
Abstract
Abstract Protein molecules are covalently bonded to a chelating agent which in turn binds a radioactive molecule. Prior to binding, the radioactive molecule is reduced with dithionite ion and then mixed with protein at a pH of 7.0 to about 8.0.
Inventors
- 👤 Edgar Haber
- 👤 Ban A. Khaw
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:51
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/58; G01N33/60; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/088; A61K51/10; A61K51/1093; A61K2123/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
53 words
A composition comprising a protein covalently bonded to a bifunctional physiologically acceptable chelating agent and technetium-99m being bound to said chelating agent, said technetium-99m being reduced with dithionite and mixing said technetium-99m with said protein covalently linked to said chelating agent at a pH of at least about 7.0 up to about 9.0.
Claim 2
Dependent Claim
53 words
A composition comprising a protein covalently bonded to a bifunctional physiologically acceptable chelating agent and technetium-99m being bound to said chelating agent, said technetium-99m being reduced with dithionite and mixing said technetium-99m with said protein covalently linked to said chelating agent at a pH of at least about 7.0 up to about 9.0.
Claim 3
Dependent Claim
14 words
The composition of claim 1 wherein said chelating agent is diethylene triamine pentaacetic acid.
Claim 4
Dependent Claim
14 words
The composition of claim 1 wherein said chelating agent is diethylene triamine pentaacetic acid.
Claim 5
Dependent Claim
16 words
The composition of any one of claims 1, 2 or 3 wherein said protein is anti-myosin.
Claim 6
Dependent Claim
16 words
The composition of any one of claims 1, 2 or 3 wherein said protein is fibrinogen.
Claim 7
Dependent Claim
17 words
The composition of any one of claims 1, 2 or 3 wherein said protein is anti-carcinoembryonic antigen.
Claim 8
Dependent Claim
18 words
The composition of any one of claims 1, 2 or 3 wherein said protein is anti-alpha feto protein.
Claim 9
Dependent Claim
18 words
The composition of any one of claims 1, 2 or 3 wherein said protein is anti-human chorionic gonadotropin.
Claim 10
Dependent Claim
57 words
The process of forming the composition of claim 1 which comprises reducing an oxidized form of said radioactive molecule with dithionite ion to obtain a reduced form of said radioactive molecule and mixing said radioactive molecule with said protein covalently linked to said chelating agent at a pH of at least about 7.0 up to about 9.0.
Claim 11
Dependent Claim
14 words
The process of claim 9 wherein said pH is between about 7.0 and 8.0.
Claim 12
Dependent Claim
15 words
The process of claim 9 wherein the source of said dithionite ion is sodium dithionite.
Claim 13
Dependent Claim
15 words
The process of claim 10 wherein the source of said dithionite ion is sodium dithionite.
Claim 14
Dependent Claim
28 words
The process of any one of claims 10, 11 or 12 wherein the oxidized form of the radioactive molecule is pertechnetate ion which is reduced to technetium-99m ion.
Claim 15
Dependent Claim
21 words
The process of any one of claims 10, 11 or 12 wherein the source of dithionite ion is particulate sodium dithionate.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-19 | 1987-06-20 | 1987-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-19 | 1991-06-20 | 1991-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-19 | 1995-06-20 | 1995-12-20 | $7700.00 | Window Closed / Lapsed |