US4250161A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and kit for the preparation of radiopharmaceuticals
Assignee: ICN Switzerland AG
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Filing: 1978-09-06
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Granted: 1981-02-10
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Expires: 1998-09-06
Abstract
Abstract For labelling organic or anorganic substances with technetium-99m in the heterogenous phase, an aqueous solution of the substance to be labelled is mixed with a pertechnetate and an aqueous suspension of Sn 2 Fe(CN) 6 , Sn 3 [Fe(CN) 6 ] 2 , SnS or SnTe and the solution of the labelled substance is separated from the solid phase after completion of the reduction of the pertechnetate. In particular, the reducing agent can be in a vial, in lyophilized or adsorbed form, as appropriate together with the substance to be labeled.
Inventors
- 👤 Marc de Schrijver
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 22:49
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K51/0489; A61K51/12; C; C01; C01C; C01C3/00; C01C3/08; C01C3/12; C01G; C01G19/00; A61K2123/00; C01P; C01P2006/00; C01P2006/44
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
140 words
A method of preparing radiopharmaceuticals with the isotope-99m, comprising mixing (a) an aqueous solution of the chemical substance to be labelled, (b) the amount of pertechnetate calculated for the labelling and (c) an aqueous suspension of a reducing agent selected from the group consisting of Sn 2 Fe(CN) 6 , Sn 3 [Fe(CN) 6 ] 2 , tin(II)-sulfide and tin(II)-telluride, in an amount which in respect of the reduction of the pertechnetate ions of the formula TcO-to technetium ions with lower valency represents an excess, wherein (a), (b) and (c) are mixed together in such a way that either the pertechnetate (b) or the suspension (c) is added last; keeping the two-phase system obtained in suspension until after completion of the reduction of the pertechnetate, the separating the solid phase from the solution containing the chemical substance labelled with technetium-99m.
Claim 2
Independent Claim
140 words
A method of preparing radiopharmaceuticals with the isotope-99m, comprising mixing (a) an aqueous solution of the chemical substance to be labelled, (b) the amount of pertechnetate calculated for the labelling and (c) an aqueous suspension of a reducing agent selected from the group consisting of Sn 2 Fe(CN) 6 , Sn 3 [Fe(CN) 6 ] 2 , tin(II)-sulfide and tin(II)-telluride, in an amount which in respect of the reduction of the pertechnetate ions of the formula TcO-to technetium ions with lower valency represents an excess, wherein (a), (b) and (c) are mixed together in such a way that either the pertechnetate (b) or the suspension (c) is added last; keeping the two-phase system obtained in suspension until after completion of the reduction of the pertechnetate, the separating the solid phase from the solution containing the chemical substance labelled with technetium-99m.
Claim 3
Dependent Claim
39 words
The method according to claim 1 , which comprises using said Sn 2 Fe(CN) 6 or said Sn 3 [(CN) 6 ] 2 in an amount of 0.0001to 0.005 mg per milligram of the chemical substance to be labelled.
Claim 4
Dependent Claim
31 words
The method according to claim 1, which comprises using said tin(II)-telluride or said tin(II)-sulfide in an amount of 0.0001 to 0.010 mg per milligram of the chemical substance to be labelled.
Claim 5
Independent Claim
22 words
The method of any one of claims 1, 2 or 3, wherein the pH-value of the solution (a) is 2 to 9.
Claim 6
Independent Claim
31 words
The method of any one of claims 1, 2 or 3, wherein the separation of the solid phase is carried out by filtration, decantation, centrifugation or adsorption on a suitable surface.
Claim 7
Independent Claim
35 words
The method according to any one of claims 1, 2 or 3, wherein the solution (a) and the suspension (c) are mixed, the mixture is lyophilized and the lyophilisate is treated with the solution (b).
Claim 8
Dependent Claim
36 words
An ampoule to carry out the method according to claim 5, wherein the wall of said ampoule is coated with a suitable inert adsorption agent and that said reduction agent is adsorbed on the adsorption agent.
Claim 9
Dependent Claim
25 words
An ampoule to carry out the method according to claim 6, comprising the lyophilisate of a mixture of the solution (a) and the suspension (c).
Claim 10
Dependent Claim
25 words
An ampoule to carry out the method according to claim 5, wherein the wall of said ampoule is coated with a layer of adsorbed tin(II)-telluride.
Claim 11
Dependent Claim
17 words
The ampoule according to claim 7, which contains a solution of the chemical substance to be labelled.
Claim 12
Dependent Claim
17 words
The ampoule according to claim 9, which contains a solution of the chemical substance to be labelled.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-10 | 1984-08-11 | 1985-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-10 | 1988-08-11 | 1989-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-10 | 1992-08-11 | 1993-02-10 | $7700.00 | Window Closed / Lapsed |