US4087516A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Body scanning agent
Assignee: GE Healthcare Ltd
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Filing: 1977-03-07
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Granted: 1978-05-02
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Expires: 1997-03-07
Abstract
Abstract A Technetium-99m labelled tin colloid for liver scanning is made by adding Technetium-99m, as an aqueous solution of pertechnetate ion TcO4-, to a reagent comprising one part by weight of sodium, potassium or ammonium fluoride and from 0.00075 to 0.75 parts by weight of stannous tin.
Inventors
- 👤 John Barry Laidler
- 👤 Maurice Alexander Alfred Stewart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 01:48
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; A61K51/02; A61K51/04; A61K51/08; A61K51/081; A61K51/1241; A61K51/1255; A61K2123/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
40 words
A packaged reagent for making Technetium-99m labelled tin colloids comprising: stannous tin, from 0.75 to 750 micrograms sodium potassium or ammonium ion, from 50 to 7000 micrograms, fluoride, from 40 to 5000 micrograms, and a container aseptically enclosing said reagent.
Claim 2
Dependent Claim
40 words
A packaged reagent for making Technetium-99m labelled tin colloids comprising: stannous tin, from 0.75 to 750 micrograms sodium potassium or ammonium ion, from 50 to 7000 micrograms, fluoride, from 40 to 5000 micrograms, and a container aseptically enclosing said reagent.
Claim 3
Dependent Claim
14 words
A packaged reagent as claimed in claim 1, wherein the reagent is a lyophilisate.
Claim 4
Dependent Claim
30 words
A packaged reagent as claimed in claim 1, wherein the reagent comprises 1 to 1000 micrograms of stannous fluoride and 0.1 to 10 milligrams of sodium, potassium or ammonium fluoride.
Claim 5
Dependent Claim
25 words
A packaged reagent as claimed in claim 3, wherein the reagent comprises about 125 micrograms of stannous fluoride and about 1 milligram of sodium fluoride.
Claim 6
Independent Claim
50 words
A method of making a Technetium-99m labelled tin colloid, which method comprises adding Technetium-99m, as an aqueous solution of pertechnetate ion TcO 4 - , to a reagent comprising one part by weight of sodium, potassium or ammonium fluoride and from 0.00075 to 0.75 parts by weight of stannous tin.
Claim 7
Independent Claim
50 words
A method of making a Technetium-99m labelled tin colloid, which method comprises adding Technetium-99m, as an aqueous solution of pertechnetate ion TcO 4 - , to a reagent comprising one part by weight of sodium, potassium or ammonium fluoride and from 0.00075 to 0.75 parts by weight of stannous tin.
Claim 8
Dependent Claim
27 words
A method as claimed in claim 5, wherein the Technetium-99m is used in the form of a solution of pertechnetate ion TcO 4 - in isotonic saline.
Claim 9
Dependent Claim
45 words
A method as claimed in claim 5, wherein the reagent is the packaged reagent comprising stannous tin, from 0.75 to 750 micrograms sodium potassium or ammonium ion, from 50 to 7000 micrograms, fluoride, from 40 to 5000 micrograms, and a container aseptically enclosing said reagent.
Claim 10
Dependent Claim
18 words
A method as claimed in claim 5. wherein the solution of pertechnetate and the reagent are both sterile.
Claim 11
Dependent Claim
28 words
A method as claimed in claim 5. wherein from 2 to 50 mCi of Technetium-99m is used per mg of sodium, potassium or ammonium fluoride in the reagent.
Claim 12
Dependent Claim
14 words
A Technetium-99m labelled tin colloid when made by the method claimed in claim 5.
Claim 13
Dependent Claim
53 words
A method of visualising the liver of a mammal which comprises injecting into the mammal an amount of the Technetium-99m labelled tin colloid claimed in claim 10 to contain from 1 to 15 mCi of Technetium-99m, allowing the Technetium-99m to become located in the liver, and observing the gamma-radiation emitted by the liver.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-01 | 1981-10-31 | 1982-05-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-01 | 1985-10-31 | 1986-05-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-01 | 1989-10-31 | 1990-05-02 | $7700.00 | Window Closed / Lapsed |