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US3968221A
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99M-Technetium labeled tin colloid radiopharmaceuticals
Assignee: United States Department of Energy
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Filing: 1974-06-10
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Granted: 1976-07-06
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Expires: 1994-06-10
Abstract
Abstract An improved 99m-technetium labeled tin(II) colloid, size-stabilized for reticuloendothelial organ imaging without the use of macromolecular stabilizers and a packaged tin base reagent and an improved method for making it are disclosed.
Inventors
- 👤 Harry S. Winchell
- 👤 Morton Barak
- 👤 Parmer Van Fleet, III
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 09:22
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; A61K2123/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
29 words
A packaged reagent for preparing size-stabilized 99m-technetium labeled colloids consisting of a 1 millimolar colloid of hydrolyzed stannous chloride in sterile, pyrogen-free water aseptically enclosed in a nitrogen-purged ampule.
Claim 2
Dependent Claim
29 words
A packaged reagent for preparing size-stabilized 99m-technetium labeled colloids consisting of a 1 millimolar colloid of hydrolyzed stannous chloride in sterile, pyrogen-free water aseptically enclosed in a nitrogen-purged ampule.
Claim 3
Dependent Claim
20 words
The packaged reagent of claim 1 wherein substantially all of the tin ions are in the reduced tin (II) state.
Claim 4
Independent Claim
66 words
A method of preparing a sterile tin (II) base reagent suitable for the preparation of size-stabilized 99m-technetium labeled colloids which comprises: a. adding sufficient anhydrous stannous chloride to sterile, pyrogen-free water to form a 1 millimolar colloid; b. filling a sterile, sealable ampule package with said colloid; c. nitrogen purging said package thereby eliminating oxygen therefrom; and d. aseptically sealing said package in an airtight condition.
Claim 5
Independent Claim
66 words
A method of preparing a sterile tin (II) base reagent suitable for the preparation of size-stabilized 99m-technetium labeled colloids which comprises: a. adding sufficient anhydrous stannous chloride to sterile, pyrogen-free water to form a 1 millimolar colloid; b. filling a sterile, sealable ampule package with said colloid; c. nitrogen purging said package thereby eliminating oxygen therefrom; and d. aseptically sealing said package in an airtight condition.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-06 | 1980-01-05 | 1980-07-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-06 | 1984-01-05 | 1984-07-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-06 | 1988-01-05 | 1988-07-06 | $7700.00 | Window Closed / Lapsed |