US3875299A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Technetium labeled tin colloid radiopharmaceuticals
Assignee: United States Department of Energy
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Filing: 1972-05-05
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Granted: 1975-04-01
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Expires: 1992-05-05
Abstract
Abstract An improved 99m- technetium labeled tin(II) colloid, size stabilized for reticuloendothelial organ imaging without the use of macromolecular stabilizers and a packaged tin base reagent and improved method for making it.
Inventors
- 👤 Harry S Winchell
- 👤 Morton Barak
- 👤 Fleet Iii Parmer Van
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 19:53
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; A61K2123/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
59 words
A 99M-TECHNETIUM LABEL TIN(II) COLLOID WHICH COLLOID IS SIZE-STABILIXED FOR SCINTIGRAPHIC IMAGING OF RETICULOENDOTHELIAL ORGANS INCLUDING THE LIVER, SPLEEN AND BONE MARROW WITHOUT THE PRESENCE OF MACROMOLECULAR STABILIZERS COMPRISING MIXED SOLUTIONS OF HYDROLIZED STANNOUS CHLORIDE WITH ITS TIN IONS SUBSTANTIALLY MAINTAINED IN THEIR REDUCED TIN(II) STATE; AND 99M-TECHNETIUM-PERTECHNETATE IN NORMAL SALINE SOLUTION THE SOLUTION BEING MIXED AT ROOM TEMPERATURE.
Claim 2
Dependent Claim
59 words
A 99M-TECHNETIUM LABEL TIN(II) COLLOID WHICH COLLOID IS SIZE-STABILIXED FOR SCINTIGRAPHIC IMAGING OF RETICULOENDOTHELIAL ORGANS INCLUDING THE LIVER, SPLEEN AND BONE MARROW WITHOUT THE PRESENCE OF MACROMOLECULAR STABILIZERS COMPRISING MIXED SOLUTIONS OF HYDROLIZED STANNOUS CHLORIDE WITH ITS TIN IONS SUBSTANTIALLY MAINTAINED IN THEIR REDUCED TIN(II) STATE; AND 99M-TECHNETIUM-PERTECHNETATE IN NORMAL SALINE SOLUTION THE SOLUTION BEING MIXED AT ROOM TEMPERATURE.
Claim 3
Independent Claim
90 words
A method for instantly making a 99m-technetium labeled tin colloid, which colloid is size-stabilized for scintigraphic imaging of reticuloendothelial organs including the liver, spleen and bone marrow without the use of macromolecular stabilizers, comprising the steps of forming a solution containing stannous tin ions by dissolving stannous chloride in pyrogen-free water; substantially eliminating all oxidants and oxidizing catalysts from said solution to maintain the tin ions in their reduced state; and then mixing said solution at room temperature with 99m-technetium pertechnetate ions in normal saline solution to form said colloid.
Claim 4
Independent Claim
90 words
A method for instantly making a 99m-technetium labeled tin colloid, which colloid is size-stabilized for scintigraphic imaging of reticuloendothelial organs including the liver, spleen and bone marrow without the use of macromolecular stabilizers, comprising the steps of forming a solution containing stannous tin ions by dissolving stannous chloride in pyrogen-free water; substantially eliminating all oxidants and oxidizing catalysts from said solution to maintain the tin ions in their reduced state; and then mixing said solution at room temperature with 99m-technetium pertechnetate ions in normal saline solution to form said colloid.
Claim 5
Dependent Claim
32 words
The method of claim 2 wherein the stannous chloride is dissolved to about a one millimolar concentration and the pertechnetate ions are present in an amount to produce 2-3 millicuries of radioactivity.
Claim 6
Dependent Claim
28 words
The method of claim 2 further comprising the step of incubating the colloid at room temperature for about 7-10 minutes after mixing the stannous and pertechnetate ion solutions.
Claim 7
Dependent Claim
32 words
The colloid of claim 1 wherein the hydrolized stannous chloride is at about a one millimolar concentration and the 99m-technetium pertechnetate ions are in an amount producing about 2-3 millicuries of radioactivity.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-31 | 1978-09-30 | 1979-04-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-31 | 1982-09-30 | 1983-04-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-31 | 1986-09-30 | 1987-04-01 | $7700.00 | Window Closed / Lapsed |