US4057615A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of tagging excipients with 99M technetium
Assignee: LA ORIS INDUSTRIE SA 31-33 RUE de la FEDERATION 75752 PARIS CEDEX 15 Cie
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Filing: 1975-07-29
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Granted: 1977-11-08
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Expires: 1995-07-29
Abstract
Abstract A method of using 99m technetium for tagging excipients in medical diagnosis by scintigraphy comprises mixing, in an aqueous solution of alkali-metal pertechnetate, an excipient and a reducing agent in the form of a complex, which complex is such that the association constant of the anion with reduced technetium is less than the association constant of the excipient with reduced technetium, thereby forming a radio-pharmaceutical substance which is a complex between the excipient and 99m technetium.
Inventors
- 👤 Andre Bardy
- 👤 Jacqueline Beydon
- 👤 Renee Gobin
- 👤 Michel Hegesippe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 08:19
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K51/048; A61K2123/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
80 words
A method of using 99m Tc for tagging excipients in medical diagnosis by scintigraphy, which method comprises mixing, in an aqueous solution of alkalimetal pertechnetate, an excipient and a reducing agent complex present in a lower concentration, wherein the association constant of the anion of the reducing agent complex with reduced technetium is less than the association constant of the excipient with reduced technetium, thus forming a radio-pharmaceutical substance which is a complex between the excipient and 99 m technetium.
Claim 2
Independent Claim
80 words
A method of using 99m Tc for tagging excipients in medical diagnosis by scintigraphy, which method comprises mixing, in an aqueous solution of alkalimetal pertechnetate, an excipient and a reducing agent complex present in a lower concentration, wherein the association constant of the anion of the reducing agent complex with reduced technetium is less than the association constant of the excipient with reduced technetium, thus forming a radio-pharmaceutical substance which is a complex between the excipient and 99 m technetium.
Claim 3
Dependent Claim
18 words
A method of tagging according to claim 1, wherein sodium pertechnetate in 9% NaCl saline solution is used.
Claim 4
Dependent Claim
29 words
A method of tagging according to claim 1, wherein the excipient is selected from among DTPA, bleomycin, albumin from human serum, erythrocytes, tetracycline, disodium citrate, polyphosphates, gluconate and dimercaptosuccinate.
Claim 5
Dependent Claim
16 words
A method of tagging according to claim 1, wherein stannous pyrophosphate is the reducing agent complex.
Claim 6
Dependent Claim
29 words
The method of claim 3, wherein said stannous pyrophosphate and said excipient are mixed together in a neutral aqueous solution prior to mixing with said solution of alkali-metal pertechnetate.
Claim 7
Dependent Claim
32 words
A method of tagging according to claim 4, wherein a solution of tin pyrophosphate is used at a pH between 5.5 and 6.5, corresponding to an Sn II content of approx. 5μg.
Claim 8
Dependent Claim
23 words
A method of tagging according to claim 4, wherein stannous pyrophosphate is used in solid form and in the form of a powder.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-07 | 1981-05-09 | 1981-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-07 | 1985-05-09 | 1985-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-07 | 1989-05-09 | 1989-11-08 | $7700.00 | Window Closed / Lapsed |