Patent US4418037A successfully refreshed from Google Patents.
US4418037A
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Color indicator composition and film for detecting hydrogen peroxide
Assignee: Fujifilm Holdings Corp
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Filing: 1982-04-19
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Granted: 1983-11-29
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Expires: 2002-04-19
Abstract
Abstract In a multilayer analysis film for detecting hydrogen peroxide by dry process which comprises a support and a reagent layer having contained therein a color indicator composition comprising peroxidase and a substance capable of causing a optically detectable change in the presence of hydrogen peroxide and peroxidase, the color indicator composition is characterized by further containing specific pyrogallol derivatives. Such pyrogallol derivatives improve stability during storage of such a multilayer analysis film.
Inventors
- 👤 Harumi Katsuyama
- 👤 Tadao Shishido
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 20:08
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/26; C12Q1/28; C12Q2326/00; C12Q2326/50; Y; Y10; Y10S; Y10S435/00; Y10S435/805; Y10S436/00; Y10S436/904; Y10T; Y10T436/00; Y10T436/14; Y10T436/142222; Y10T436/143333; Y10T436/144444; Y10T436/20; Y10T436/206664
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
111 words
In a color indicator composition for detecting hydrogen peroxide comprising a substance having peroxidase activity and a substance capable of causing a detectable change in the presence of hydrogen peroxide and said substance having a peroxidase activity, the color indicator composition for detecting hydrogen peroxide comprising a pyrogallol derivative represented by formula (1): ##STR12## wherein Q 1 represents a nitro group, a cyano group, an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, an aralkyl group, a carboxyl group or a --COOQ 2 group wherein Q 2 represents an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group or an aralkyl group.
Claim 2
Dependent Claim
111 words
In a color indicator composition for detecting hydrogen peroxide comprising a substance having peroxidase activity and a substance capable of causing a detectable change in the presence of hydrogen peroxide and said substance having a peroxidase activity, the color indicator composition for detecting hydrogen peroxide comprising a pyrogallol derivative represented by formula (1): ##STR12## wherein Q 1 represents a nitro group, a cyano group, an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, an aralkyl group, a carboxyl group or a --COOQ 2 group wherein Q 2 represents an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group or an aralkyl group.
Claim 3
Dependent Claim
30 words
The color indicator composition for detecting hydrogen peroxide of claim 1 wherein said substance capable of causing a detectable change is a combination of a hydrogen donor and a coupler.
Claim 4
Dependent Claim
91 words
The composition of claim 2 wherein said hydrogen donor is at least one compound selected from the group consisting of a 4-substituted antipyrine, a 2-hydrazinobenzothiazoline, a p-halogenophenol and an N,N-disubstituted-p-phenylenediamine represented by formula (2): ##STR13## wherein R 5 and R 6 each represents an alkyl group, an alkoxyalkyl group, a hydroxyalkyl group, a cyanoalkyl group, a halogenoalkyl group or an acylaminoalkyl group and, R 5 and R 6 may be the same or different; and R 7 represents a hydrogen atom, an alkyl group, an akoxy group or a halogen atom.
Claim 5
Dependent Claim
106 words
The composition of claim 2 wherein said coupler is at least one compound selected from the group consisting of a naphthol, a phenol, a pyrazolone and an N,N-disubstituted aniline represented by formula (3): ##STR14## wherein R 1 and R 2 each represents a hydrogen atom, an alkyl group or an alkoxy group and, R 1 and R 2 may be the same or different; and R 3 and R 4 each represents an alkyl group, an alkoxyalkyl group, a hydroxyalkyl group, an aminoalkyl group, a cyanoalkyl group, a halogenoalkyl group or an acylaminoalkyl group and, R 3 and R 4 may be the same or different.
Claim 6
Dependent Claim
11 words
The composition of claim 3 wherein said hydrogen donor is 4-aminoantipyrine.
Claim 7
Dependent Claim
126 words
In a quantitative analysis film which comprises a support and a reagent layer having contained therein a color indicator composition for detecting hydrogen peroxide comprising a substance having a peroxidase activity and a substance capable of causing a detectable change in the presence of hydrogen peroxide and the substance having a peroxidase activity, the quantitative analysis film wherein the composition contains a pyrogallol derivative represented by formula (1): ##STR15## wherein Q 1 represents a nitro group, a cyano group, an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, an aralkyl group, a carboxyl group or a --COOQ 2 group wherein Q 2 represents an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group or an aralkyl group.
Claim 8
Dependent Claim
126 words
In a quantitative analysis film which comprises a support and a reagent layer having contained therein a color indicator composition for detecting hydrogen peroxide comprising a substance having a peroxidase activity and a substance capable of causing a detectable change in the presence of hydrogen peroxide and the substance having a peroxidase activity, the quantitative analysis film wherein the composition contains a pyrogallol derivative represented by formula (1): ##STR15## wherein Q 1 represents a nitro group, a cyano group, an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, an aralkyl group, a carboxyl group or a --COOQ 2 group wherein Q 2 represents an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group or an aralkyl group.
Claim 9
Dependent Claim
26 words
The quantitative analysis film of claim 6 wherein said substance capable of causing a detectable change is a combination of a hydrogen donor and a coupler.
Claim 10
Dependent Claim
23 words
The quantitative analysis film of claim 6 wherein said reagent layer is further composed of a color-forming reaction layer and a dye-fixing layer.
Claim 11
Dependent Claim
15 words
The quantitative analysis film of claim 6 wherein said reagent layer is a single layer.
Claim 12
Dependent Claim
92 words
The quantitative analysis film of claim 7, wherein said hydrogen donor is at least one compound selected from the group consisting of a 4-aminoantipyrine, a 2-hydrazinobenzothiazoline, a p-halogenophenol and an N,N-disubstituted-p-phenylenediamine represented by formula (2): ##STR16## wherein R 5 and R 6 each represents an alkyl group, an alkoxyalkyl group, a hydroxyalkyl group, a cyanoalkyl group, a halogenoalkyl group or an acylaminoalkyl group and, R 5 and R 6 may be the same or different; and R 7 represents a hydrogen atom, an alkyl group, an alkoxy group or a halogen atom.
Claim 13
Dependent Claim
111 words
The quantitative analysis film of claim 7, 8 or 9 wherein said coupler is at least one compound selected from the group consisting of a naphthol, a phenol, a pyrazolone and an N,N-disubstituted aniline represented by formula (3): ##STR17## wherein R 1 and R 2 each represents a hydrogen atom, an alkyl group or an alkoxy group and, R 1 and R 2 may be the same or different; and R 3 and R 4 each represents an alkyl group, an alkoxyalkyl group, a hydroxyalkyl group, an aminoalkyl group, a cyanoalkyl group, a halogenoalkyl group or an acylaminoalkyl group and, R 3 and R 4 may be the same or different.
Claim 14
Dependent Claim
13 words
The quantitative analysis film of claim 7, wherein said hydrogen donor is 4-aminoantipyrine.
Claim 15
Dependent Claim
38 words
The quantitative analysis film of claim 7, wherein said reagent layer is provided between a support and a porous layer and, the porous layer is in a fluid contact with the reagent layer to form an integral form.
Claim 16
Dependent Claim
16 words
The quantitative analysis film of claim 7, wherein said composition is contained in a polymer binder.
Claim 17
Dependent Claim
24 words
The quantitative analysis film of claim 7, wherein said reagent layer further contains a mordanting agent comprising an anionic polymer or a cationic polymer.
Claim 18
Dependent Claim
25 words
The quantitative analysis film of claim 8 wherein said dye-fixing layer further contains a polymer mordanting agent comprising an anionic polymer or a cationic polymer.
Claim 19
Dependent Claim
17 words
The quantitative analysis film of claim 6 wherein said support is porous and impregnated with said composition.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1986-11-28 | 1987-05-30 | 1987-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-28 | 1991-05-30 | 1991-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-28 | 1995-05-30 | 1995-11-29 | $7700.00 | Window Closed / Lapsed |