US4119405A
Expired / Lapsed
US
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Test means and method for interference resistant determination of oxidizing substances
Assignee: Bayer Corp
•
Filing: 1978-02-13
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Granted: 1978-10-10
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Expires: 1998-02-13
Abstract
Abstract Test means, such as a composition or device, method of making a test device and process for determination of at least one oxidizing substance, such as a peroxide, are disclosed. More particularly, the contemplated test means comprises a hydrazone and a hydroxynapthalenesulfonate selected from the group 4,5-dihydroxy-2,7-naphthalene disulfonic acid (chromotropic acid) and 1-hydroxy-2-naphthalene sulfonic acid. Further provided is a test system for the determination of a constituent in a sample, having means responsive to the presence of said constituent in said sample to produce at least one oxidizing substance and a composition for determining said at least one oxidizing substance, having the improvement wherein said composition comprises a hydrazone and a hydroxynapthalenesulfonate selected from the group of 4,5-dihydroxy-2,7-naphthalene disulfonic acid and 1-hydroxy-2-naphthalene sulfonic acid. The test system is preferably of the type which determines peroxides formed from enzymatic conversion of constituents in biological fluids. When in the form of compositions the test means can optionally be incorporated with a carrier, such as a tablet or matrix, to provide a test device. The indicator system is highly sensitive to low levels of body fluid constituents to be detected while also being highly resistant to interfering reducing substances, such as ascorbic acid, often present in body fluids.
Inventors
- 👤 Charles Tak Wai Lam
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 01:05
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/62; C12Q1/26; C12Q1/28; C12Q1/54; C12Q2326/00; C12Q2326/32; Y; Y10; Y10S; Y10S435/00; Y10S435/805; Y10T; Y10T436/00; Y10T436/14; Y10T436/142222; Y10T436/143333; Y10T436/144444
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
25 words
Test means for the determination of an oxidizing substance which comprises a hydrazone and hydroxynapthalenesulfonate selected from the group of 4,5-dihydroxy-2,7-napthalene-disulfonic acid and 1-hydroxy-2-napthalene-sulfonic acid.
Claim 2
Dependent Claim
25 words
Test means for the determination of an oxidizing substance which comprises a hydrazone and hydroxynapthalenesulfonate selected from the group of 4,5-dihydroxy-2,7-napthalene-disulfonic acid and 1-hydroxy-2-napthalene-sulfonic acid.
Claim 3
Dependent Claim
12 words
The test means of claim 1 wherein said hydroxynapthalenesulfonate is 4,5-dihydroxy-2,7-napthalene-disulfonic acid.
Claim 4
Dependent Claim
12 words
The test means of claim 1 wherein said hydrazone is 3-methyl-2-benzothiazolinone hydrazone.
Claim 5
Dependent Claim
12 words
The test means of claim 2 wherein said hydrazone is 3-methyl-2-benzothiazolinone hydrazone.
Claim 6
Dependent Claim
24 words
A test device for the determination of an oxidizing substance which comprises a carrier matrix and, incorporated therewith, the test means of claim 1.
Claim 7
Dependent Claim
24 words
A test device for the determination of an oxidizing substance which comprises a carrier matrix and, incorporated therewith, the test means of claim 4.
Claim 8
Dependent Claim
11 words
The device of claim 5 wherein the carrier matrix is bibulous.
Claim 9
Dependent Claim
22 words
A test device for the determination of an oxidizing substance which comprises a tablet incorporated with the test means of claim 1.
Claim 10
Dependent Claim
27 words
A process for the preparation of a device for the determination of oxidizing substances which comprises incorporating a carrier matrix with the test means of claim 1.
Claim 11
Dependent Claim
20 words
The process of claim 9 wherein said incorporating is impregnating with a solution of said test means, followed by drying.
Claim 12
Dependent Claim
30 words
A process for determination of an oxidizing substance in a liquid sample which comprises contacting said sample with the test means of claim 1 and observing any resultant color formed.
Claim 13
Dependent Claim
31 words
A process for determination of an oxidizing substance in a liquid sample which comprises contacting said sample with the test device of claim 5 and observing any resultant color formed thereon.
Claim 14
Dependent Claim
67 words
In a test system for the determination of a constituent in a sample, having means responsive to the presence of said constituent in said sample to produce at least one oxidizing substance and having a composition for determining said at least one oxidizing substance, the improvement wherein said composition comprises a hydrazone and a hydroxynapthalenesulfonate selected from the group of 4,5-dihydroxy-2,7-napthalene disulfonic acid and 1-hydroxy-2-napthalene sulfonic acid.
Claim 15
Dependent Claim
67 words
In a test system for the determination of a constituent in a sample, having means responsive to the presence of said constituent in said sample to produce at least one oxidizing substance and having a composition for determining said at least one oxidizing substance, the improvement wherein said composition comprises a hydrazone and a hydroxynapthalenesulfonate selected from the group of 4,5-dihydroxy-2,7-napthalene disulfonic acid and 1-hydroxy-2-napthalene sulfonic acid.
Claim 16
Dependent Claim
12 words
The test system of claim 13 wherein said hydroxy-napthalenesulfonate is 4,5-dihydroxy-2,7-napthalene-disulfonic acid.
Claim 17
Dependent Claim
12 words
The test system of claim 13 wherein said hydrazone is 3-methyl-2-benzothiazolinone hydrazone.
Claim 18
Dependent Claim
12 words
The test system of claim 14 wherein said hydrazone is 3-methyl-2-benzothiazolinone hydrazone.
Claim 19
Dependent Claim
17 words
A test device which comprises a carrier matrix and, incorporated therewith, the test system of claim 13.
Claim 20
Dependent Claim
17 words
A test device which comprises a carrier matrix and, incorporated therewith, the test system of claim 16.
Claim 21
Dependent Claim
11 words
The device of claim 17 wherein the carrier matrix is bibulous.
Claim 22
Dependent Claim
15 words
A test device which comprises a tablet incorporated with the test system of claim 13.
Claim 23
Dependent Claim
22 words
A process for the preparation of a test device which comprises incorporating a carrier matrix with the test system of claim 13.
Claim 24
Dependent Claim
20 words
The process of claim 21 wherein said incorporating is impregnating with a solution of said test system, followed by drying.
Claim 25
Dependent Claim
29 words
A process for determination of a constituent in a liquid sample which comprises contacting said sample with the test system of claim 13 and observing any resultant color formed.
Claim 26
Dependent Claim
29 words
A process for determination of a constituent in a liquid sample which comprises contacting said sample with the test device of claim 17 and observing any resultant color formed.
References Cited (Backward Citations)
US3979262A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-09 | 1982-04-10 | 1982-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-09 | 1986-04-10 | 1986-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-09 | 1990-04-10 | 1990-10-10 | $7700.00 | Window Closed / Lapsed |