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US4409334A
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Stabilized thrombin preparation
Assignee: Roche Diagnostics GmbH
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Filing: 1981-04-15
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Granted: 1983-10-11
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Expires: 2001-04-15
Abstract
Abstract The present invention provides a stabilized thrombin preparation in solid or dissolved form, especially for analytical purposes, containing, as a stabilizer, serum albumin together with at least one protease inhibitor and at least one chelate former.
Inventors
- 👤 Helmut Lill
- 👤 Knut Bartl
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:27
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/6429; C12N9/96; C12Q; C12Q1/00; C12Q1/56; C12Y; C12Y304/00; C12Y304/21; C12Y304/21005; G; G01; G01N; G01N2333/00; G01N2333/81; G01N2333/8107; G01N2333/811; G01N2333/8114; G01N2333/8117; G01N2333/90; G01N2333/914; G01N2333/948; G01N2333/974; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/105831
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
33 words
Stabilized thrombin preparation comprising thrombin and as a stabilizer serum albumin together with at least one protease inhibitor which does not inhibit thrombin itself and at least one tetraligand or hexaligand chelate former.
Claim 2
Dependent Claim
33 words
Stabilized thrombin preparation comprising thrombin and as a stabilizer serum albumin together with at least one protease inhibitor which does not inhibit thrombin itself and at least one tetraligand or hexaligand chelate former.
Claim 3
Dependent Claim
11 words
Stabilized thrombin preparation as claimed in claim 1, in solid form.
Claim 4
Dependent Claim
11 words
Stabilized thrombin preparation as claimed in claim 1 in dissolved form.
Claim 5
Dependent Claim
28 words
Stabilized thrombin preparation as claimed in claim 1 containing 0.01 to 0.2 M chelate former, 1 to 100 μg./ml. protease inhibitor and 5 to 100 mg./ml. serum albumin.
Claim 6
Dependent Claim
15 words
Stabilized thrombin preparation as claimed in claim 1, wherein the chelate former is a hexaligand.
Claim 7
Dependent Claim
14 words
Stabilized thrombin preparation as claimed in claim 5, wherein the hexaligand is ethylenediamine-tetraacetic acid.
Claim 8
Dependent Claim
14 words
Stabilized thrombin prepearation as claimed in claim 1, wherein the protease inhibitor is aprotonin.
Claim 9
Dependent Claim
27 words
Stabilized thrombin preparation as claimed in claim 1 containing 0.03 to 0.1 M ethylenediamine-tetraacetic acid, 5 to 20 μg./ml. aprotonin and 10 to 50 mg./ml. serum albumin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-10 | 1987-04-11 | 1987-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-10 | 1991-04-11 | 1991-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-10 | 1995-04-11 | 1995-10-11 | $7700.00 | Window Closed / Lapsed |