Patent US4407761A successfully refreshed from Google Patents.
US4407761A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the production of ω-amino-1-hydroxyalkylidene-1,1-bisphosphonic acid
Assignee: Henkel AG and Co KGaA
•
Filing: 1981-04-16
•
Granted: 1983-10-04
•
Expires: 2001-04-16
Abstract
Abstract A process for the preparation of a ω-amino-1-hydroxyalkylidine-1,1-biphosphonic acid of the formula ##STR1## wherein n is an integer from 3 to 5, consisting essentially of the steps of reacting an aminocarboxylic acid of the formula NH.sub.2 --CH.sub.2 --(CH.sub.2).sub.m --COOH wherein m is an integer from 2 to 4, with a phosphonating reactant selected from the group consisting of (a) a mixture of phosphorous acid and PCl 3 , (b) a mixture of phosphorous acid and PCl 5 , and (c) a mixture of phosphorous acid and POCl 3 , hydrolyzing the reaction mixture with a strong acid which does not oxidize aminophosphonic acids, and recovering said ω-amino-1-hydroxyalkylidene-1,1-bisphosphonic acid.
Inventors
- 👤 Helmut Blum
- 👤 Karl-Heinz Worms
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:43
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3839; C07F9/3873; C02; C02F; C02F1/00; C02F1/68; C02F1/683; C02F5/00; C02F5/08; C02F5/10; C02F5/14
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
112 words
A process for the preparation of a ω-amino-1-hydroxyalkylidine-1,1-bisphosphonic acid of the formula: ##STR5## wherein n is an integer from 3 to 5, consisting essentially of the steps of: (1) reacting an aminocarboxylic acid of the formula: NH.sub.2 --CH.sub.2 --(CH.sub.2).sub.m --COOH wherein m is an integer from 2 to 4, with a phosphonating reactant selected from the group consisting of: (a) a mixture of phosphorous acid and PCl 3 , (b) a mixture of phosphorous acid and PCl 5 , and (c) a mixture of phosphorous acid and POCl 3 (2) hydrolyzing the reaction mixture with concentrated hydrochloric acid which does not oxidize aminophosphonic acids, by heating, and (3) recovering said ω-amino-1-hydroxyalkylidene-1,1-bisphosphonic acid.
Claim 2
Dependent Claim
112 words
A process for the preparation of a ω-amino-1-hydroxyalkylidine-1,1-bisphosphonic acid of the formula: ##STR5## wherein n is an integer from 3 to 5, consisting essentially of the steps of: (1) reacting an aminocarboxylic acid of the formula: NH.sub.2 --CH.sub.2 --(CH.sub.2).sub.m --COOH wherein m is an integer from 2 to 4, with a phosphonating reactant selected from the group consisting of: (a) a mixture of phosphorous acid and PCl 3 , (b) a mixture of phosphorous acid and PCl 5 , and (c) a mixture of phosphorous acid and POCl 3 (2) hydrolyzing the reaction mixture with concentrated hydrochloric acid which does not oxidize aminophosphonic acids, by heating, and (3) recovering said ω-amino-1-hydroxyalkylidene-1,1-bisphosphonic acid.
Claim 3
Dependent Claim
39 words
The process of claim 1 wherein the reaction with said phosphonating reactant is conducted in the presence of an inert organic diluent which does not solublize the reaction product and the diluent is removed prior to said hydrolyzing step.
Claim 4
Dependent Claim
26 words
The process of claim 1 or 2 wherein said reaction with a phosphonating reactant is conducted at a temperature of from 80° C. to 130° C.
Claim 5
Dependent Claim
9 words
6-Amino-1-hydroxyhexylidene diphosphonic acid of the summary formula (1): ##STR6##
Claim 6
Dependent Claim
9 words
6-Amino-1-hydroxyhexylidene diphosphonic acid of the summary formula (1): ##STR6##
References Cited (Backward Citations)
DE2130794A1
Cited
US4054598A
Cited
DE2658961C3
Cited
DE2702631A1
Cited
DE2745083A1
Cited
US4267108A
Cited
US4327039A
Cited
US4304734A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-03 | 1987-04-04 | 1987-10-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-03 | 1991-04-04 | 1991-10-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-03 | 1995-04-04 | 1995-10-04 | $7700.00 | Window Closed / Lapsed |