Trans-Δ2 -pge alkylsulphonyl amides

Abstract

Abstract Prostaglandin analogues of the formula: ##STR1## (wherein R 1 represents an alkyl group containing from 1 to 4 carbon atoms, R 2 represents a single bond or an alkylene group containing from 1 to 5 carbon atoms, R 3 represents a hydrogen atom, an alkyl or alkoxy group containing from 1 to 8 carbon atoms, a cycloalkyl or cycloalkyloxy group containing from 4 to 7 carbon atoms and being unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, or a phenyl or phenoxy group unsubstituted or substituted by at least one halogen atom, trifluoromethyl group or alkyl group containing from 1 to 4 carbon atoms, R 4 represents a hydrogen atom or a hydroxy-protecting group which may be removed under acidic conditions, X represents an ethylene group or a cis-vinylene group, the double bonds between the carbon atoms in positions 2 and 3 and between the carbon atoms in positions 13 and 14 are both in trans-configuration, and the wavy line attached to the carbon atom in position 15 represents α- or β-configuration or a mixture thereof, provided that, when R 2 represents a single bond, R 3 does not represent an alkoxy group, a cycloalkoxy group or a phenoxy group) and cyclodextrin clathrates thereof are useful compounds: those in which R 4 represents a hydrogen atom possess selective prostaglandin-like properties.

Inventors

• 👤 Takashi Yamato
• 👤 Hirofumi Endo
• 👤 Kimiichiro Matsumoto
• 👤 Hajimu Miyake

Bibliographic Details