US4024174A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tranes-delta 2-prostaglandins
Assignee: Ono Pharmaceutical Co Ltd
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Filing: 1974-12-19
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Granted: 1977-05-17
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Expires: 1994-12-19
Abstract
Abstract Trans-Δ 2 -prostaglandin compounds are disclosed of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## R 1 represents an alkyl group containing from 1 to 10 carbon atoms, or an alkyl group containing from 1 to 6 carbon atoms carrying a phenyl substituent or a cycloalkyl substituent of 5 to 7 carbon atoms, R 2 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, and R 3 ' represents a hydrogen atom or an alkyl group containing from 1 to 12 carbon atoms, the double bonds in the 2- and 5-positions being in the trans- and cis-configurations respectively. These compounds are indicated in the management of conditions such as autoimmune conditions, e.g. rheumatoid arthritis.
Inventors
- 👤 Masaki Hayashi
- 👤 Seiji Kori
- 👤 Hirohisa Wakatsuka
- 👤 Yoshitaka Konishi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 00:45
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/02; C07D307/04; C07D307/18; C07D307/20; C07C; C07C405/00; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
117 words
A compound of the formula: ##STR28## wherein R 1 represents an alkyl group containing from 1 to 10 carbon atoms, or an alkyl group containing from 1 to 6 carbon atoms carrying a phenyl substituent or a cycloalkyl substituent of 5 to 7 carbon atoms, R 2 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, X represents ethylene or trans-vinylene, and R 3' represents a hydrogen atom or an alkyl group containing from 1 to 12 carbon atoms, the double bonds in the 2- and 5-positions being in the trans- and cis-configurations respectively, and cyclodextrin clathrates thereof, and non-toxic salts of the acids wherein R 3' represents a hydrogen atom.
Claim 2
Dependent Claim
117 words
A compound of the formula: ##STR28## wherein R 1 represents an alkyl group containing from 1 to 10 carbon atoms, or an alkyl group containing from 1 to 6 carbon atoms carrying a phenyl substituent or a cycloalkyl substituent of 5 to 7 carbon atoms, R 2 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, X represents ethylene or trans-vinylene, and R 3' represents a hydrogen atom or an alkyl group containing from 1 to 12 carbon atoms, the double bonds in the 2- and 5-positions being in the trans- and cis-configurations respectively, and cyclodextrin clathrates thereof, and non-toxic salts of the acids wherein R 3' represents a hydrogen atom.
Claim 3
Dependent Claim
38 words
A compound according to claim 1 in which ##STR29## is a grouping of the formula: ##STR30## wherein R 8 and R 9 which may be the same or different each represent a hydrogen atom or a methyl group.
Claim 4
Dependent Claim
41 words
A compound according to claim 1 in which ##STR31## in a grouping of the formula: ##STR32## wherein the carbon atom in the 15-position carries a methyl group, or the carbon atoms in the 15- and 16-positions each carry a methyl group.
Claim 5
Dependent Claim
25 words
A compound according to claim 1 in which ##STR33## is a grouping of the formula: ##STR34## wherein R 10 represents a phenyl or cyclohexyl radical.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 wherein X represents trans-vinylene.
Claim 7
Dependent Claim
18 words
A compound according to claim 1 which is trans-Δ 2 -PGF 2 .sub.α and the methyl ester thereof.
Claim 8
Dependent Claim
18 words
A compound according to claim 1 which is 15-methyl-trans-Δ 2 -PGF 2 .sub.α and the methyl ester thereof.
Claim 9
Dependent Claim
17 words
A compound according to claim 1 which is 16-methyl-trans-Δ 2 -PGF 2 and the methyl ester thereof.
Claim 10
Dependent Claim
18 words
A compound according to claim 1 which is 16(R)-methyl-trans-Δ 2 -PGF 2 .sub.α and the methyl ester thereof.
Claim 11
Dependent Claim
18 words
A compound according to claim 1 which is 17-methyl-trans-Δ 2 -PGF 2 .sub.α and the methyl ester thereof.
Claim 12
Dependent Claim
18 words
A compound according to claim 1 which is 15,16-dimethyl-trans-Δ 2 -PGF 2 .sub.α and the methyl ester thereof.
Claim 13
Dependent Claim
18 words
A compound according to claim 1 which is 16-phenyl-ω-trinor-trans-Δ 2 -PGF 2 .sub.α and the methyl ester thereof.
Claim 14
Dependent Claim
18 words
A compound according to claim 1 which is 16-cyclohexyl-ω-trinor-trans-Δ 2 -PGF 2 .sub.α and the methyl ester thereof.
References Cited (Backward Citations)
DE2261496A1
Cited
BE817383A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-16 | 1980-11-15 | 1981-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-16 | 1984-11-15 | 1985-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-16 | 1988-11-15 | 1989-05-17 | $7700.00 | Window Closed / Lapsed |