US4024179A
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Substituted ω-pentanorprostaglandins
Assignee: Pfizer Inc
•
Filing: 1973-11-07
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Granted: 1977-05-17
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Expires: 1993-11-07
Abstract
Abstract Substituted novel ω-pentanorprostaglandins and various novel intermediates and reagents used in their preparation.
Inventors
- 👤 Jasjit S. Bindra
- 👤 Michael R. Johnson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 00:59
CPC Classifications
C; C07; C07D; C07D257/00; C07D257/02; C07D257/04; C07C; C07C405/00; C07C405/0008; C07C405/0041; C07D307/00; C07D307/77; C07D307/93; C07D307/935; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12; C07D405/00; C07D405/02; C07D405/12; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/40; C07F9/4003; C07F9/4006; C07F9/54; C07F9/5407; C07F9/547; C07F9/6524
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
122 words
A compound of the structure: ##STR15## and its C 15 epimer; wherein Ar is phenyl, 3,4-dimethoxyphenyl, 3,4-methylenedioxyphenyl, 3,4,5-trimethoxyphenyl; α- or β-naphthyl or mono-substituted phenyl wherein said substituent is halo, trifluoromethyl, phenyl, lower alkyl or lower alkoxy; R is hydrogen or lower alkyl; n and m are each integers from 0 to 3 with the proviso that the sum of n and m does not exceed 3; W and L are each a single bond or cis double bond; Z is single bond or trans double bond; M is keto, ##STR16## N is hydrogen or α-hydroxyl; X is p-phenyl-phenoxycarbonyl; and wherein L, M and N are so selected as to complete the structure of a prostaglandin of the A, E, or F series.
Claim 2
Dependent Claim
122 words
A compound of the structure: ##STR15## and its C 15 epimer; wherein Ar is phenyl, 3,4-dimethoxyphenyl, 3,4-methylenedioxyphenyl, 3,4,5-trimethoxyphenyl; α- or β-naphthyl or mono-substituted phenyl wherein said substituent is halo, trifluoromethyl, phenyl, lower alkyl or lower alkoxy; R is hydrogen or lower alkyl; n and m are each integers from 0 to 3 with the proviso that the sum of n and m does not exceed 3; W and L are each a single bond or cis double bond; Z is single bond or trans double bond; M is keto, ##STR16## N is hydrogen or α-hydroxyl; X is p-phenyl-phenoxycarbonyl; and wherein L, M and N are so selected as to complete the structure of a prostaglandin of the A, E, or F series.
Claim 3
Dependent Claim
15 words
A compound according to claim 1 of the structure: ##STR17## and its C 15 epimer.
Claim 4
Dependent Claim
19 words
The compound of claim 1 wherein M is ##STR18## L is a single bond, and N is a α-hydroxyl.
Claim 5
Dependent Claim
15 words
A compound according to claim 1 of the structure: ##STR19## and its C 15 epimer.
Claim 6
Dependent Claim
15 words
A compound according to claim 1 of the structure: ##STR20## and its C 15 epimer.
Claim 7
Dependent Claim
22 words
The compound of claim 1 wherein n and m are each 0, Ar is phenyl and said prostaglandin is PGE 2 .
Claim 8
Dependent Claim
22 words
The compound of claim 1 wherein n and m are each 0, Ar is phenyl and said prostaglandin is PGF 2 .sub.α.
Claim 9
Dependent Claim
22 words
The compound of claim 1 wherein n is 0, m is 0, Ar is phenyl and said prostaglandin is PGF 2 .sub.β.
Claim 10
Dependent Claim
22 words
The compound of claim 1 wherein n is 0, m is 0, Ar is phenyl and said prostaglandin is PGA 2 .
Claim 11
Dependent Claim
22 words
The compound of claim 1 wherein n is 0, m is 1, Ar is phenyl and said prostaglandin is PGE 2 .
Claim 12
Dependent Claim
22 words
The compound of claim 1 wherein n is 0, m is 1, Ar is phenyl and said prostaglandin is PGF 2 .sub.α.
Claim 13
Dependent Claim
12 words
A compound of claim 2 wherein n and m are each 0.
Claim 14
Dependent Claim
12 words
A compound of claim 2 wherein n and m are each 1.
Claim 15
Dependent Claim
12 words
A compound of claim 4 wherein n and m are each 0.
Claim 16
Dependent Claim
12 words
A compound of claim 4 wherein n and m are each 1.
Claim 17
Dependent Claim
32 words
A compound according to claim 4 wherein W is a cis double bond, Z is a trans double bond, R is hydrogen, n and m are each 0, and Ar is phenyl.
Claim 18
Dependent Claim
31 words
A compound according to claim 3 wherein W is a cis double bond, Z is a trans double bond, R is hydrogen, n and m are each 0, Ar is phenyl.
Claim 19
Dependent Claim
31 words
A compound according to claim 2 wherein W is a cis double bond, Z is a trans double bond, R is hydrogen, n and m are each 0, Ar is phenyl.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-16 | 1980-11-15 | 1981-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-16 | 1984-11-15 | 1985-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-16 | 1988-11-15 | 1989-05-17 | $7700.00 | Window Closed / Lapsed |