US3954741A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N-substituted prostaglandin carboxamides
Assignee: Pfizer Inc
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Filing: 1973-05-30
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Granted: 1976-05-04
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Expires: 1993-05-30
Abstract
Abstract The N-substituted prostaglandin carboxamides and various intermediates employed in their preparation. Such prostaglandin analogs exhibit the same activity profiles as the corresponding natural prostaglandin but with increased duration of action and increased selectivity of action.
Inventors
- 👤 Thomas K. Schaaf
- 👤 Leonard J. Czuba
- 👤 Hans-Jurgen E. Hess
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 01:05
CPC Classifications
C; C07; C07C; C07C405/00; C07C405/0008; C07C405/0041; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/54; C07F9/5407
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
128 words
A compound of the structure: ##SPC11## wherein R is alkanoyl having from 2-8 carbon atoms or cycloalkanoyl from 4 to 8 carbon atoms; aryoyl or substituted aryoyl of from 7 to 11 carbon atoms wherein said substituent is methyl, halogen, or methoxy; alkylsulfonyl of from 1 to 7 carbon atoms; arylsulfonyl or substituted arylsulfonyl wherein said substituent is methyl, halogen, or methoxy; R 1 is hydrogen or alkyl having from 1 to 3 carbon atoms; R 2 is alkyl having from 5 to 11 carbon atoms; W is a single bond or cis double bond; Z is single bond or trans double bond; and the C 11 and C 15 esters thereof wherein said esterifying group is formyl, alkanoyl, having from 2 to 5 carbon atoms, or benzoyl.
Claim 2
Dependent Claim
128 words
A compound of the structure: ##SPC11## wherein R is alkanoyl having from 2-8 carbon atoms or cycloalkanoyl from 4 to 8 carbon atoms; aryoyl or substituted aryoyl of from 7 to 11 carbon atoms wherein said substituent is methyl, halogen, or methoxy; alkylsulfonyl of from 1 to 7 carbon atoms; arylsulfonyl or substituted arylsulfonyl wherein said substituent is methyl, halogen, or methoxy; R 1 is hydrogen or alkyl having from 1 to 3 carbon atoms; R 2 is alkyl having from 5 to 11 carbon atoms; W is a single bond or cis double bond; Z is single bond or trans double bond; and the C 11 and C 15 esters thereof wherein said esterifying group is formyl, alkanoyl, having from 2 to 5 carbon atoms, or benzoyl.
Claim 3
Dependent Claim
31 words
A compound according to claim 1 wherein R is acetyl, R 1 is hydrogen, R 2 is n-pentyl, W is a cis double bond, and Z is a trans double bond.
Claim 4
Dependent Claim
31 words
A compound according to claim 1 wherein R is propionyl, R 1 is hydrogen, R 2 is n-pentyl, W is a cis double bond, and Z is a trans double bond.
Claim 5
Dependent Claim
31 words
A compound according to claim 1 wherein R is cyclopropylcarbonyl, R 1 is hydrogen, R 2 is n-pentyl, W is a cis double bond, and Z is a trans double bond.
Claim 6
Dependent Claim
31 words
A compound according to claim 1 wherein R is pivaloyl, R 1 is hydrogen, R 2 is n-pentyl, W is a cis double bond, and Z is a trans double bond.
Claim 7
Dependent Claim
31 words
A compound according to claim 1 wherein R is methanesulfonyl, R 1 is hydrogen, R 2 is n-pentyl, W is a cis double bond, and Z is a trans double bond.
Claim 8
Dependent Claim
31 words
A compound according to claim 1 wherein R is acetyl, R 1 is hydrogen, R 2 is 1,1-dimethylpent-1-yl, W is a cis double bond, and Z is a trans double bond.
Claim 9
Dependent Claim
31 words
A compound according to claim 1 wherein R is methanesulfonyl, R 1 is hydrogen, R 2 is 1,1-dimethylpent-1-yl, W is a cis double bond, and Z is a trans double bond.
Claim 10
Dependent Claim
32 words
A compound according to claim 1 wherein R is 2-thiophenesulfonyl, R 1 is hydrogen and R 2 is n-pentyl, W is a cis double bond and Z is a trans double bond.
Claim 11
Dependent Claim
31 words
A compound according to claim 1 wherein R is methanesulfonyl, R 1 is hydrogen and R 2 is n-pentyl, W is a single bond and Z is a trans double bond.
Claim 12
Dependent Claim
31 words
A compound according to claim 1 wherein R is acetyl, R 1 is hydrogen and R 2 is n-pentyl, W is a single bond and Z is a trans double bond.
References Cited (Backward Citations)
US3751463A
Cited
DE2150361A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-04 | 1979-11-03 | 1980-05-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-04 | 1983-11-03 | 1984-05-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-04 | 1987-11-03 | 1988-05-04 | $7700.00 | Window Closed / Lapsed |