US4339430A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibacterial oral composition
Assignee: Colgate Palmolive Co
•
Filing: 1980-12-31
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Granted: 1982-07-13
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Expires: 2000-12-31
Abstract
Abstract An antibacterial oral composition effective to promote oral hygiene containing an antibacterial antiplaque agent and an additive which reduces staining of dental surfaces without substantially diminishing the antibacterial and antiplaque activity of the agent. Bis-biguanido hexanes, such as chlorhexidine and alexidine, and quaternary ammonium salts, such as benzethonium chloride and cetyl pyridinium chloride are typical examples of antibacterial agents. The antistain additive is a copolymer of glutamic acid, tyrosine and optionally alanine.
Inventors
- 👤 Abdul Gaffar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 17:40
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/84; A61K8/88; A61K8/30; A61K8/40; A61K8/41; A61K8/416; A61Q; A61Q11/00; A61K2800/00; A61K2800/40; A61K2800/52
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
106 words
An oral dentifrice toothpaste or mouthwash composition comprising an orally acceptable vehicle, at least one cationic nitrogen-containing antibacterial antiplaque agent whose use has been observed to lead to staining of dental surfaces, and as anti-staining additive, an effective stain-inhibiting amount of a copolymer consisting essentially of: (A) n units having the molecular configuration ##STR7## (B) m units having the molecular configuration ##STR8## and (C) p units having the molecular configuration ##STR9## the ratio of (n+m):p ranging from about 5:1 to about 9:5:1 and the ratio of m:n ranging from 0:1 to about 0.6:1, the molecular weight of the copolymer ranging from about 5,000 to about 150,000.
Claim 2
Dependent Claim
106 words
An oral dentifrice toothpaste or mouthwash composition comprising an orally acceptable vehicle, at least one cationic nitrogen-containing antibacterial antiplaque agent whose use has been observed to lead to staining of dental surfaces, and as anti-staining additive, an effective stain-inhibiting amount of a copolymer consisting essentially of: (A) n units having the molecular configuration ##STR7## (B) m units having the molecular configuration ##STR8## and (C) p units having the molecular configuration ##STR9## the ratio of (n+m):p ranging from about 5:1 to about 9:5:1 and the ratio of m:n ranging from 0:1 to about 0.6:1, the molecular weight of the copolymer ranging from about 5,000 to about 150,000.
Claim 3
Dependent Claim
31 words
An oral composition according to claim 1 wherein the ratio of n:m:p in the copolymer is about 9:0:1 and the copolymer has a molecular weight of about 17,000 to about 21,000.
Claim 4
Dependent Claim
31 words
An oral composition according to claim 1 wherein the ratio of n:m:p in the copolymer is about 6:3:1 and the copolymer has a molecular weight of about 80,000 to about 100,000.
Claim 5
Dependent Claim
52 words
The oral composition of claims 1, 2 or 3 wherein said antibacterial antiplaque agent is present in an amount of about 0.001 to about 15% by weight based on the free base form of said agent and said additive is present in an amount of about 0.01 to about 10% by weight.
Claim 6
Dependent Claim
33 words
The oral composition of claims 1, 2 or 3 wherein said antibacterial antiplaque agent is present in an amount of about 0.01 to about 5% by weight, based on its free base form.
Claim 7
Dependent Claim
18 words
The oral composition of claims 1, 2 or 3 wherein said antibacterial antiplaque agent is a substituted guanidine.
Claim 8
Dependent Claim
33 words
The oral composition of claims 1, 2 or 3 wherein said antibacterial antiplaque agent is a pharmaceutically acceptable water soluble salt of an agent selected from the group consisting of chlorhexidine and alexidine.
Claim 9
Dependent Claim
23 words
The oral composition of claims 1, 2 or 3 wherein said antibacterial antiplaque agent is a pharmaceutically acceptable water soluble salt of chlorhexidine.
Claim 10
Dependent Claim
17 words
The oral composition of claims 1, 2 or 3 wherein said antibacterial antiplaque agent is benzethonium chloride.
Claim 11
Dependent Claim
31 words
The oral composition of claims 1, 2 or 3 wherein said antibacterial antiplaque agent is a quaternary ammonium compound containing 1 to 2 alkyl groups of 8 to 20 carbon atoms.
Claim 12
Dependent Claim
18 words
The oral composition of claims 1, 2 or 3 wherein said antibacterial antiplaque agent is cetyl pyridinium chloride.
Claim 13
Dependent Claim
26 words
The oral composition of claims 1, 2 or 3 which is a mouthwash having a pH of about 4.5 to about 9 and an aqueous-alcohol vehicle.
Claim 14
Dependent Claim
22 words
The mouthwash composition of claim 12 containing, approximately by weight, 0.01 to 5.0% of benzethonium chloride based on its free base form.
Claim 15
Dependent Claim
28 words
The mouthwash composition of claim 12 containing, approximately by weight, 0.01 to 5.0% of a water soluble pharmaceutically acceptable salt of chlorhexidine, based on its free base form.
Claim 16
Dependent Claim
17 words
The mouthwash composition of claim 12 containing, approximately by weight, 0.01 to 5% of cetyl pyridinium chloride.
Claim 17
Dependent Claim
34 words
The oral composition of claims 1, 2 or 3 which is a toothpaste having a pH of about 4.5 to about 9, a liquid vehicle, a gelling agent, and a dentally acceptable polishing agent.
Claim 18
Independent Claim
23 words
A method of improving oral hygiene comprising applying an oral composition as defined in claims 1, 2 or 3 to said dental surfaces.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-07-12 | 1986-01-11 | 1986-07-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-07-12 | 1990-01-11 | 1990-07-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-07-12 | 1994-01-11 | 1994-07-13 | $7700.00 | Window Closed / Lapsed |