US4118475A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibacterial oral composition
Assignee: Colgate Palmolive Co
•
Filing: 1976-08-16
•
Granted: 1978-10-03
•
Expires: 1996-08-16
Abstract
Abstract An antibacterial oral composition effective to promote oral hygiene containing an antibacterial antiplaque agent and an additive which reduces staining of dental surfaces without substantially diminishing the antibacterial and antiplaque activity of the agent. Bis-biguanido hexanes, such as chlorhexidine and alexidine, and quaternary ammonium salts, such as benzethonium chloride and cetyl pyridinium chloride, are typical examples of antibacterial agents. The antistain additive is a diphosphono pyrrolidone compound, such as pyrrolidone-5,5-diphosphonic acid, or salts thereof.
Inventors
- 👤 Abdul Gaffar
- 👤 Hollandra P. Niles
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 03:45
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/55; A61K8/40; A61K8/41; A61K8/416; A61K8/43; A61K8/49; A61K8/4906; A61K8/4926; A61Q; A61Q11/00; A61K2800/00; A61K2800/40; A61K2800/52
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
66 words
An oral composition comprising an oral vehicle, at least one nitrogen containing antibacterial antiplaque agent selected from the group consisting of cationic bis-guanido and quaternary ammonium antibacterial antiplaque agents and a water soluble diphosphono pyrrolidone compound of the formula: ##STR5## wherein the R's are independently hydrogen, C 1 to C 6 alkyl or C 2 to C 6 hydroxyalkyl, and X is an orally acceptable cation.
Claim 2
Dependent Claim
66 words
An oral composition comprising an oral vehicle, at least one nitrogen containing antibacterial antiplaque agent selected from the group consisting of cationic bis-guanido and quaternary ammonium antibacterial antiplaque agents and a water soluble diphosphono pyrrolidone compound of the formula: ##STR5## wherein the R's are independently hydrogen, C 1 to C 6 alkyl or C 2 to C 6 hydroxyalkyl, and X is an orally acceptable cation.
Claim 3
Dependent Claim
50 words
The oral composition of claim 1 wherein said antibacterial antiplaque agent is present in amount to provide about 0.001% to about 15% by weight based on the free base form of said agent and said diphosphono pyrrolidone compound is present in amount of about 0.01% to about 10% by weight.
Claim 4
Dependent Claim
47 words
The oral composition of claim 2 wherein said antibacterial antiplaque agent is present in amount of about 0.01% to about 5% by weight based on the free base form of said agent and said diphosphono pyrrolidone compound is present in a molar excess relative to said agent.
Claim 5
Dependent Claim
16 words
The oral composition of claim 2 wherein said antibacterial antiplaque agent is a bis-guanido antiplaque agent.
Claim 6
Dependent Claim
30 words
The oral composition of claim 4 wherein said antibacterial antiplaque agent is a pharmaceuticaly acceptable water soluble salt of an agent selected from the group consisting of chlorhexidine and alexidine.
Claim 7
Dependent Claim
20 words
The oral composition of claim 5 wherein said antibacterial antiplaque agent is a pharmaceutically acceptable water soluble salt of chlorhexidine.
Claim 8
Dependent Claim
14 words
The oral composition of claim 2 wherein said antibacterial antiplaque agent is benzethonium chloride.
Claim 9
Dependent Claim
28 words
The oral composition of claim 2 wherein said antibacterial antiplaque agent is a quaternary ammonium compound containing 1 to 2 alkyl groups of 8 to 20 carbon atoms.
Claim 10
Dependent Claim
15 words
The oral composition of claim 8 wherein said antibacterial antiplaque agent is cetyl pyridinium chloride.
Claim 11
Dependent Claim
20 words
The oral composition of claim 2 wherein said diphosphono pyrrolidone compound is pyrrolidone-5,5-diphosphonic acid or an orally acceptable salt thereof.
Claim 12
Dependent Claim
26 words
The oral composition of claim 1 wherein said vehicle is an aqueous-alcohol and said composition is a mouthwash of pH of about 4.5 to about 9.
Claim 13
Dependent Claim
39 words
The oral composition of claim 1 wherein said vehicle comprises a liquid vehicle and a gelling agent and a dentally acceptable polishing material is present and said composition is a toothpaste of pH of about 4.5 to about 9.
Claim 14
Dependent Claim
43 words
The mouthwash composition of claim 11 containing about 0.01% to about 5.0% based on its free base weight of benzethonium chloride and, relative thereto, a molar excess within the range of about 0.1% to about 5% by weight of said diphosphono pyrrolidone compound.
Claim 15
Dependent Claim
48 words
The mouthwash composition of claim 11 containing about 0.01% to about 5% based on its free base weight of a water-soluble pharmaceutically acceptable salt of chlorhexidine and, relative thereto, a molar excess within the range of about 0.1% to about 5% by weight of said diphosphono pyrrolidone compound.
Claim 16
Dependent Claim
24 words
A method of improving oral hygiene comprising applying to the oral cavity an effective amount of an oral composition as defined in claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-02 | 1982-04-03 | 1982-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-02 | 1986-04-03 | 1986-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-02 | 1990-04-03 | 1990-10-03 | $7700.00 | Window Closed / Lapsed |