US4256731A
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US
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Oral Compositions
Assignee: GlaxoSmithKline LLC
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Filing: 1979-10-26
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Granted: 1981-03-17
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Expires: 1999-10-26
Abstract
Abstract Oral compositions useful for controlling dental plaque and gingivitis and for preventing caries are produced comprising a cationic antimicrobial agent and a combination of anti-stain agents which reduce the staining effect of the cationic antimicrobial.
Inventors
- 👤 Stephen N. Curtis
- 👤 Hridaya N. Bhargava
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 08:14
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/41; A61K8/416; A61K8/43; A61K8/44; A61K8/49; A61K8/4906; A61K8/4926; A61Q; A61Q11/00; A61K2800/00; A61K2800/40; A61K2800/52
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
133 words
In an oral composition for controlling dental plaque and gingivitis and for preventing caries which comprises from 0.01% to about 1.0% w/v of a cationic antimicrobial agent useful for controlling dental plaque and gingivitis and for preventing caries selected from the group having a tendency to stain teeth consisting of a bisbiguanide and a quaternary ammonium compound, the improvement which comprises from 0.1% to 3.5% of a composition which comprises an effective amount of a nonionic surfactant exhibiting anti-stain characteristics and an effective amount of a member selected from the group consisting of an amino acid exhibiting anti-stain characteristics, a dicarboxylic aci and a tricarboxylic acid or a mixture thereof which exhibits anti-stain characteristics said member being present in a molar excess of about 10:1 to about 20:1 over the cationic anti-microbial agent.
Claim 2
Dependent Claim
133 words
In an oral composition for controlling dental plaque and gingivitis and for preventing caries which comprises from 0.01% to about 1.0% w/v of a cationic antimicrobial agent useful for controlling dental plaque and gingivitis and for preventing caries selected from the group having a tendency to stain teeth consisting of a bisbiguanide and a quaternary ammonium compound, the improvement which comprises from 0.1% to 3.5% of a composition which comprises an effective amount of a nonionic surfactant exhibiting anti-stain characteristics and an effective amount of a member selected from the group consisting of an amino acid exhibiting anti-stain characteristics, a dicarboxylic aci and a tricarboxylic acid or a mixture thereof which exhibits anti-stain characteristics said member being present in a molar excess of about 10:1 to about 20:1 over the cationic anti-microbial agent.
Claim 3
Dependent Claim
13 words
A composition according to claim 1 wherein the antimicrobial agent is a bisbiguanide.
Claim 4
Dependent Claim
15 words
A composition according to claim 1 wherein the antimicrobial agent is a quaternary ammonium compound.
Claim 5
Dependent Claim
21 words
A composition according to claim 1 wherein the amount of antimicrobial agent is from 0.01% to about 1.0% w/w or w/v.
Claim 6
Dependent Claim
20 words
A composition according to claim 1 wherein the amount of anti-stain composition is from 0.1% to 1.0% w/w or w/v.
Claim 7
Dependent Claim
19 words
A composition according to claim 1 wherein the pH of the composition is from about 5.0 to about 8.0.
Claim 8
Dependent Claim
52 words
A composition according to claim 1 wherein the agent is a bisbiguanide which is 1,6-bis (2-ethylhexyl diguanido hexane) dihydrochloride; 1,6-bis (2-ethylhexyl diguanido hexane) dihydrofluoride; 1,6-bis (2-ethylhexyl diguanido octane) dihydrochloride; 1,6-bis (2-ethylhexyl diguanido nonane) dihydrochloride; 1,6-bis (2-ethylhexyl diguanido dodecane) dihydrochloride; or 1,6-di (4-chlorophenyl diguanido hexane) dihydrochloride or the diacetate or digluconate salt thereof.
Claim 9
Dependent Claim
44 words
A composition according to claim 3 wherein the agent is a quaternary ammonium compound which is dodcecyl dimethyl-(2-phenoxyethyl)-ammonium; benzyldimethyl (2-)2-(p-1,3,3-tetramethyl butyl phenoxy)ethoxyl)ethyl) ammonium; p-bromobenzyl-dimethyl-γ-(2'-isopropyl, 4'-chloro, 5'-methyl phenoxy)propyl ammonium; 1-hexadecyl-pyridinium salt; acylcholaminoformyl-methyl pyridinium chloride-iodide complex; 1-alkyl-4-aminoquinaldinium salt; decamethylene bis(4-aminoquinaldinum chloride) or hexadecamethylene bis (isoquinolinium chloride).
Claim 10
Dependent Claim
62 words
A composition according to claim 1 wherein the nonionic surfactant is a mono- or di-glyceride; a sorbitan fatty acid ester; a polyoxyethylene sorbitan fatty acid ester; a polyoxyethylene sorbitol ester; a polyoxyethylene acid; a polyoxyethylene alcohol; a poly (oxyethylene)-poly(oxypropylene)-poly (oxyethylene) polymer; a polyoxyethylene N-substituted fatty acid amide; a poly(ethylene glycol) p-nonyl phenyl ether; an octyl phenoxy poly ethoxy-ethanol; or a poly siloxane.
Claim 11
Dependent Claim
32 words
A composition according to claim 1 wherein the amino acid is aspartic acid, cysteine, glutamic acid, paraamino benzoic acid, α-aminoadipic acid, N-(p-amino benzoyl) glutamic acid, p-amino hippuric acid or p-amino phenylacetic acid.
Claim 12
Dependent Claim
34 words
A composition according to claim 1 wherein the carboxylic acid is citric acid, α-ketoglutaric acid, malic acid, succinic acid, oxalic acid, adipic acid, fumaric acid, glutaric acid, maleic acid, tartaric acid or malonic acid.
Claim 13
Dependent Claim
33 words
A composition according to claim 1 wherein the amino acid, the carboxylic acid or the furanolactone is present in a molar excess of about 10:1 to about 25:1 over the cationic antimicrobial agent.
Claim 14
Dependent Claim
9 words
A composition according to claim 1 in mouthwash form.
Claim 15
Dependent Claim
10 words
A composition according to claim 1 in oral rinse form.
Claim 16
Dependent Claim
9 words
A composition according to claim 1 in dentifrice form.
Claim 17
Dependent Claim
10 words
A composition according to claim 1 in tooth powder form.
Claim 18
Dependent Claim
10 words
A composition according to claim 1 in oral solution form.
Claim 19
Dependent Claim
9 words
A composition according to claim 1 in gel form.
Claim 20
Dependent Claim
16 words
A composition according to claim 1 in a form suitable for dispensing through a water jet.
Claim 21
Dependent Claim
11 words
A composition according to claim 1 in a breath freshener form.
Claim 22
Dependent Claim
10 words
A composition according to claim 1 in an aerosol form.
Claim 23
Dependent Claim
10 words
A composition according to claim 1 in a gargle form.
Claim 24
Dependent Claim
12 words
A composition according to claim 1 in the form of a troche.
Claim 25
Dependent Claim
9 words
A composition according to claim 1 in lozenge form.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-16 | 1984-09-15 | 1985-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-16 | 1988-09-15 | 1989-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-16 | 1992-09-15 | 1993-03-17 | $7700.00 | Window Closed / Lapsed |