US3887701A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibacterial oral compositions containing preservative-antioxidants
Assignee: Colgate Palmolive Co
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Filing: 1974-11-01
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Granted: 1975-06-03
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Expires: 1994-11-01
Abstract
Abstract Oral products containing bis-biguanido hexanes are disclosed which are effective in preventing the accumulation of bacterial plaque and do not stain teeth. Incorporation of certain reducing agents has been found to prevent dental staining while maintaining the activity of bis-biguanido hexanes in oral products. Effective reducing agents include, hydrogenated coumarin, and tri-hydroxylated benzoic acid and its lower alkyl (C1-C4) esters.
Inventors
- 👤 Julius Harvey Nachtigal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:11
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/36; A61K8/368; A61K8/37; A61K8/40; A61K8/43; A61K8/49; A61K8/4973; A61K8/498
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
54 words
AN ORAL PREPARATION COMPRISING A NON-TOXIC BISBIGUANIDO HEXANE COMPOUND AS ANTIBACTERIAL AGENT IN AMOUNT OF FROM ABOUT 0.01% TO ABOUT 5% BY WEIGHT BASED ON THE FREE BASE THEREOF, A VEHICLE FOR SAID AGENT COMPATIBLE THEREWITH AND AS A STABILIZING AGENT FROM ABOUT 0.01% TO ABOUT 5% BY WEIGHT OF HYDROGENATED COUMARIN REDUCING AGENT.
Claim 2
Dependent Claim
54 words
AN ORAL PREPARATION COMPRISING A NON-TOXIC BISBIGUANIDO HEXANE COMPOUND AS ANTIBACTERIAL AGENT IN AMOUNT OF FROM ABOUT 0.01% TO ABOUT 5% BY WEIGHT BASED ON THE FREE BASE THEREOF, A VEHICLE FOR SAID AGENT COMPATIBLE THEREWITH AND AS A STABILIZING AGENT FROM ABOUT 0.01% TO ABOUT 5% BY WEIGHT OF HYDROGENATED COUMARIN REDUCING AGENT.
Claim 3
Dependent Claim
54 words
An oral preparation comprising a non-toxic bisbiguanido hexane compound as antibacterial agent in amount of from about 0.01% to about 5% by weight based on the free base thereof, a vehicle for said agent compatible therewith and as a stabilizing agent from about 0.01% to about 5% by weight of hydrogenated coumarin reducing agent.
Claim 4
Dependent Claim
54 words
An oral preparation comprising a non-toxic bisbiguanido hexane compound as antibacterial agent in amount of from about 0.01% to about 5% by weight based on the free base thereof, a vehicle for said agent compatible therewith and as a stabilizing agent from about 0.01% to about 5% by weight of hydrogenated coumarin reducing agent.
Claim 5
Dependent Claim
43 words
The oral preparation of claim 1 wherein the oral preparation contains an additional antibacterial agent which is present in minor amount with respect to this bis-biguanido hexane compound and the total amount of antibacterial agents is about 0.01% to about 5% by weight.
Claim 6
Dependent Claim
26 words
The oral preparation of claim 1 wherein this bis-biguanido hexane compound is selected from the group consisting of 1,6-di-(p-chlorophenyl biguanido)hexane; 1,6-bis(2-ethylhexyl biguanido)hexane, and water-soluble salts thereof.
Claim 7
Dependent Claim
17 words
The oral preparation of claim 3 wherein the antibacterial agent is a water-soluble salt of 1,6-di-(p-chlorophenyl biguanido)hexane.
Claim 8
Dependent Claim
27 words
The oral preparation of claim 1 wherein said vehicle contains about 20-99% by weight of a solid, water-insoluble polishing material and the oral preparation is a dentifrice.
Claim 9
Dependent Claim
13 words
The oral preparation of claim 5 wherein said polishing material includes sodium metaphosphate.
Claim 10
Dependent Claim
20 words
The oral preparation of claim 5 wherein said dental vehicle also contains 0.05-5% by weight of a surface active agent.
Claim 11
Dependent Claim
13 words
The oral preparation of claim 7 wherein the surface active agent is nonionic.
Claim 12
Dependent Claim
39 words
The oral preparation of claim 1 wherein said vehicle contains about 70-99.9% by weight of a mixture of water and alcohol in a ratio of about 1:1 to about 20:1 by weight and said oral preparation is a mouthwash.
Claim 13
Dependent Claim
19 words
The oral preparation of claim 9 wherein the vehicle also contains 0.05-5% by weight of a surface active agent.
Claim 14
Dependent Claim
13 words
The oral preparation of claim 10 wherein the surface active agent is nonionic.
Claim 15
Dependent Claim
70 words
An oral preparation comprising a nontoxic bisbiguanido hexane compound as antibacterial agent in amount of from about 0.01% to about 5% by weight based on the free base thereof, a vehicle for said agent compatible therewith and as a stabilizing agent from about 0.01% to about 5% by weight of a reducing agent selected from the group consisting of tri-hydroxylated benzoic acid and lower alkyl esters of tri-hydroxylated benzoic acid.
Claim 16
Dependent Claim
70 words
An oral preparation comprising a nontoxic bisbiguanido hexane compound as antibacterial agent in amount of from about 0.01% to about 5% by weight based on the free base thereof, a vehicle for said agent compatible therewith and as a stabilizing agent from about 0.01% to about 5% by weight of a reducing agent selected from the group consisting of tri-hydroxylated benzoic acid and lower alkyl esters of tri-hydroxylated benzoic acid.
Claim 17
Dependent Claim
14 words
The oral preparation of claim 12 wherein the reducing agent is tri-hydroxylated benzoic acid.
Claim 18
Dependent Claim
18 words
The oral preparation of claim 12 wherein the reducing agent is the methyl ester of tri-hydroxylated benzoic acid.
Claim 19
Dependent Claim
18 words
The oral preparation of claim 12 wherein the reducing agent is the n-propyl ester of tri-hydroxylated benzoic acid.
Claim 20
Dependent Claim
43 words
The oral preparation of claim 12 wherein the oral preparation contains an additional antibacterial agent which is present in minor amount with respect to the bis-biguanido hexane compound and the total amount of antibacterial agents is about 0.01% to about 5% by weight.
Claim 21
Dependent Claim
28 words
The oral preparation of claim 12 wherein the bis-biguanido hexane compound is selected from the group consisting of 1,6-di-(p-chlorophenyl biguanido) hexane; 1,6-bis(2-ethylhexyl biguanido) hexane, and water-soluble salts thereof.
Claim 22
Dependent Claim
18 words
The oral preparation of claim 17 wherein the antibacterial agent is a water-soluble salt of 1,6-di-(p-chlorophenyl biguanido) hexane.
Claim 23
Dependent Claim
39 words
The oral preparation of claim 12 wherein the vehicle contains about 70-99.9% by weight of a mixture of water and alcohol in a ratio of about 1:1 to about 20:1 by weight and said oral preparation is a mouthwash.
Claim 24
Dependent Claim
19 words
The oral preparation of claim 19 wherein the vehicle also contains 0.05-5% by weight of a surface active agent.
Claim 25
Dependent Claim
27 words
The oral preparation of claim 12 wherein said vehicle contains about 20-99% by weight of a solid, water-insoluble polishing material and the oral preparation is a dentifrice.
Claim 26
Dependent Claim
13 words
The oral preparation of claim 21 wherein said polishing material includes sodium metaphosphate.
Claim 27
Dependent Claim
19 words
The oral preparation of claim 21 wherein said dental vehicle contains 0.05-5% by weight of a surface active agent.
References Cited (Backward Citations)
US3574823A
Cited
US3804946A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-06-02 | 1978-12-02 | 1979-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-06-02 | 1982-12-02 | 1983-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-06-02 | 1986-12-02 | 1987-06-03 | $7700.00 | Window Closed / Lapsed |