US3925543A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibacterial oral compositions containing preservative-antioxidants
Assignee: Colgate Palmolive Co
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Filing: 1973-11-01
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Granted: 1975-12-09
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Expires: 1993-11-01
Abstract
Abstract Oral products containing bis-biguanido hexane antibacterial agents are disclosed which are effective in preventing the accumulation of bacterial plaque and which do not stain teeth. Incorporation of a suitable reducing agent, such as ascorbic acid, has been found to prevent dental staining while maintaining the activity of the bis-biguanido hexanes in oral products.
Inventors
- 👤 John Donohue
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 23:06
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/43; A61K8/67; A61K8/676; A61K2800/00; A61K2800/40; A61K2800/52; A61K2800/522
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
110 words
AN ORAL DENTAL PLAQUE AND STAIN FORMATION PREVENTING PREPARATION CONSISTING ESSENTIALLY OF AN AQUEOUS VEHICLE HAVING A PH IN THE RANGE OF ABOUT 4.5 TO ABOUT 7 WHICH AQUEOUS VEHICLE CONTAINS FEROM ABOUT 0.01 PERCENT TO 5 PERCENT BY WEIGHT OF A NON-TOXIC WATER-SOLUBLE BIS-BIGUANIDO HEXANE COMPOUND AS ANTIBACTERIAL DENTAL PLAQUE FORMATION PREVENT ING AGENT WHICH IS SELECTED FROM THE GROUP CONSISTING OF 1,6DI-(P-CHLOROPHENYL BIGUANDIO) HEXANE, 1,6-BIS-(2-ETHYLHEXYL BIGUANIDO) HEXANE AND SALTS THEREOF, AND ABOUT 0.1 PERCENT TO 5 PERCENT BY WEIGHT OF ASCORBIC ACID AS A STABILIZING AGENT WHICH IS EFFECTIVE TO INHIBIT DENTAL STAIN FORMATION OTHERWISE CAUSED BY SAID ANTIBACTERIAL AGENT AT LEVELS ESTABLISHED AS EFFECTIVE FOR PLAQUE REDUCTION.
Claim 2
Dependent Claim
110 words
AN ORAL DENTAL PLAQUE AND STAIN FORMATION PREVENTING PREPARATION CONSISTING ESSENTIALLY OF AN AQUEOUS VEHICLE HAVING A PH IN THE RANGE OF ABOUT 4.5 TO ABOUT 7 WHICH AQUEOUS VEHICLE CONTAINS FEROM ABOUT 0.01 PERCENT TO 5 PERCENT BY WEIGHT OF A NON-TOXIC WATER-SOLUBLE BIS-BIGUANIDO HEXANE COMPOUND AS ANTIBACTERIAL DENTAL PLAQUE FORMATION PREVENT ING AGENT WHICH IS SELECTED FROM THE GROUP CONSISTING OF 1,6DI-(P-CHLOROPHENYL BIGUANDIO) HEXANE, 1,6-BIS-(2-ETHYLHEXYL BIGUANIDO) HEXANE AND SALTS THEREOF, AND ABOUT 0.1 PERCENT TO 5 PERCENT BY WEIGHT OF ASCORBIC ACID AS A STABILIZING AGENT WHICH IS EFFECTIVE TO INHIBIT DENTAL STAIN FORMATION OTHERWISE CAUSED BY SAID ANTIBACTERIAL AGENT AT LEVELS ESTABLISHED AS EFFECTIVE FOR PLAQUE REDUCTION.
Claim 3
Dependent Claim
24 words
The oral preparation of claim 1 wherein the bis-biguanido hexane compound is present in amount of about 0.1 percent to 1 percent by weight.
Claim 4
Dependent Claim
17 words
The oral preparation of claim 2 wherein the antibacterial agent is a water-soluble salt of 1,6-di-(p-chlorophenyl biguanido)hexane.
Claim 5
Dependent Claim
41 words
The oral preparation of claim 1 wherein the oral preparation contains an additional antibacterial agent which is present in minor amount with respect to the bis-biguanido hexane compound and the total amount of antibacterial agents is up to 5% by weight.
Claim 6
Dependent Claim
35 words
The oral preparation of claim 2 wherein the vehicle contains a mixture of water and alcohol in a ratio of from about 1:1 to about 20:1 by weight and said oral preparation is a mouthwash.
Claim 7
Dependent Claim
29 words
The oral preparation of claim 5 wherein the vehicle contains a fluorine-providing compound in amount sufficient to release from 0.005 percent to 1 percent by weight of fluoride ion.
Claim 8
Dependent Claim
13 words
The oral prepartion of claim 6 wherein the fluorine-providing compound is stannous fluoride.
Claim 9
Dependent Claim
13 words
The oral preparation of claim 6 wherein the fluorine-providing compound is sodium fluoride.
Claim 10
Dependent Claim
13 words
The oral preparation of claim 6 wherein the fluorine-providing compound is sodium monofluorophosphate.
Claim 11
Dependent Claim
23 words
The oral preparation of claim 5 wherein the vehicle contains from 0.05 percent to 5 percent by weight of a surface active agent.
Claim 12
Dependent Claim
17 words
The oral preparation of claim 10 wherein the surface active agent is a nonionic surface active agent.
References Cited (Backward Citations)
US2470906A
Cited
US3342687A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-08 | 1979-06-09 | 1979-12-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-08 | 1983-06-09 | 1983-12-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-08 | 1987-06-09 | 1987-12-09 | $7700.00 | Window Closed / Lapsed |