Aminoalkyl-1,2,4-triazoles

Claim 1

A compound according to formula 1 or a pharmacologically acceptable salt thereof, wherein m is zero, one, 2 or 3; wherein n is zero, one or 2, wherein R 1 is: (a) 1-piperidinyl substituted at the 3 or 4 position by R 15 , wherein R 15 is defined as below; (b) --N(CH 3 )--(CH 2 ) p --R 15 , wherein R 15 and p are defined as below and wherein p is 1, 2, or 3; or (c) --NH--(CH 2 ) p --R 15 wherein R 15 is as defined as below and wherein p is 1, 2, or 3; wherein R 4 is: (a) hydrogen; (b) alkyl of one to three carbon atoms, inclusive; (c) R 54 OCH 2 --, wherein R 54 is as defined below; (d) --CH(R 35 )(OH); (e) --R 35 (f) --SH; (g) S(O) q R 17 , wherein q is zero, one or two; and R 17 is as defined below; (h) 1-hydroxy-1-cyclohexyl; or (i) 1-cyclohexen-1yl; wherein R 5 , R 15 , R 25 , and R 35 are the same or different and are (i) 2, 3, or 4 pyridinyl, or (ii) phenyl substituted by zero to 2 chloro, fluoro, bromo, alkyl of from one to 3 carbon atoms, or alkoxy of from one to 3 carbon atoms, or (iii) phenyl substituted by one trifluoromethyl and zero to one of the previous phenyl substituents; wherein R 6 is: (a) hydrogen; (b) --OR 54 ; (c) alkanoyloxy of from one to 3 carbon atoms; or (d) alkyl of from one to 3 carbon atoms; with the proviso that when m is zero, R 6 does not contain oxygen; and wherein R 17 is methyl, phenyl, benzyl, or 2-phenylethyl; and wherein R 54 is hydrogen or alkyl of one to 3 carbon atoms; or an enantiomer when R 4 is --CH(R 35 )OH or when R 6 is not hydrogen or diastereomer when R 4 is --CH(R 35 )OH and R 6 is not hydrogen