2-{8 3,5-Disubstituted-4H-1,2,4-triazol-4-yl{9 benzhydrol
Abstract
Abstract Compounds of the formula VI tr wherein R and R1 are hydrogen, methyl or ethyl, or together is piperidino, pyrrolidino or morpholino; wherein R2 is hydrogen, chlorine or fluorine; and wherein R3 is hydrogen or fluorine, are prepared by reducing a 2-(3,5-disubstituted-4H1,2,4-triazol-4-yl) benzophenone to obtain the corresponding 2(3,5-disubstituted-4H-1,2,4-triazol-4-yl)benzhydrol or by reducing with borane a 4-(2-benzoylphenyl)-5-Substituted-4H1,2,4-triazole-3-carboxaldehyde 3-(0-acyloxime) (obtained by acylating the corresponding oxime to give the corresponding 2-(3(aminomethyl)-5-substituted-4H-1,2,4-triazol-4-yl)benzhydrol. The novel compounds of formula VI and the pharmacologically acceptable acid addition salts thereof are active sedatives.
Inventors
- 👤 Martin Gall
- 👤 Jr Jackson B Hester
Bibliographic Details
Claims Analysis
Total Claims: 8References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-06 | 1979-04-07 | 1979-10-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-06 | 1983-04-07 | 1983-10-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-06 | 1987-04-07 | 1987-10-07 | $7700.00 | Window Closed / Lapsed |