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US3910943A Expired / Lapsed US ⏱️ 0.0 years remaining

2-{8 3,5-Disubstituted-4H-1,2,4-triazol-4-yl{9 benzhydrol

Assignee: Pharmacia and Upjohn Co
•
Filing: 1973-10-29
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Granted: 1975-10-07
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Expires: 1993-10-29
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Abstract

Abstract Compounds of the formula VI tr wherein R and R1 are hydrogen, methyl or ethyl, or together is piperidino, pyrrolidino or morpholino; wherein R2 is hydrogen, chlorine or fluorine; and wherein R3 is hydrogen or fluorine, are prepared by reducing a 2-(3,5-disubstituted-4H1,2,4-triazol-4-yl) benzophenone to obtain the corresponding 2(3,5-disubstituted-4H-1,2,4-triazol-4-yl)benzhydrol or by reducing with borane a 4-(2-benzoylphenyl)-5-Substituted-4H1,2,4-triazole-3-carboxaldehyde 3-(0-acyloxime) (obtained by acylating the corresponding oxime to give the corresponding 2-(3(aminomethyl)-5-substituted-4H-1,2,4-triazol-4-yl)benzhydrol. The novel compounds of formula VI and the pharmacologically acceptable acid addition salts thereof are active sedatives.

Inventors

  • 👤 Martin Gall
  • 👤 Jr Jackson B Hester

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-09 04:47
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; A; A23; A23K; A23K20/00; A23K20/10; A23K20/116; C07D249/00; C07D249/02; C07D249/08; C07D249/10

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 2 words
5-CHLORO-2-(5-METHYL-3-((DIMETHYLAMINO)METHYL-4H1,2,4-TRIAZOL -4YL)BENZHYDROL.
Claim 2
Dependent Claim 2 words
5-CHLORO-2-(5-METHYL-3-((DIMETHYLAMINO)METHYL-4H1,2,4-TRIAZOL -4YL)BENZHYDROL.
Claim 3
Dependent Claim 1 words
5-Chloro-2'',6''-difluoro-(5-methyl-3-(dimethylamino)-methyl)-4H-1,2,4-triazol-4-yl)benzhydrol.
Claim 4
Dependent Claim 1 words
5-Chloro-2'',6''-difluoro-(5-methyl-3-(dimethylamino)-methyl)-4H-1,2,4-triazol-4-yl)benzhydrol.
Claim 5
Dependent Claim 2 words
2'',5-Dichloro-2-(5-methyl-3-((dimethylamino)methyl)-4H-1,2,4-triazol-4 -yl)benzhydrol.
Claim 6
Dependent Claim 2 words
2'',5-Dichloro-2-(5-methyl-3-((dimethylamino)methyl)-4H-1,2,4-triazol-4 -yl)benzhydrol.
Claim 7
Dependent Claim 1 words
2'',5-Dichloro-2-(5-methyl-3-(aminomethyl)-4H-1,2,4-triazol-4-yl)benzhydrol.
Claim 8
Dependent Claim 1 words
2'',5-Dichloro-2-(5-methyl-3-(aminomethyl)-4H-1,2,4-triazol-4-yl)benzhydrol.

References Cited (Backward Citations)

US3813412A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1978-10-06 1979-04-07 1979-10-07 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1982-10-06 1983-04-07 1983-10-07 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1986-10-06 1987-04-07 1987-10-07 $7700.00 Window Closed / Lapsed

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