US4115572A
Expired / Lapsed
US
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Imidazo-[1,5-d]-as-triazin-1(2H)-ones and method of ameliorating asthma
Assignee: Wyeth Holdings LLC
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Filing: 1977-10-18
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Granted: 1978-09-19
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Expires: 1997-10-18
Abstract
Abstract There are provided substituted imidazo[1,5-d]-as-triazin-1(2H)-ones useful as anti-asthmatic agents.
Inventors
- 👤 Rolf Paul
- 👤 Judith Menschik
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:20
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
31 words
A compound of the formula: ##STR3## wherein R is selected from the group consisting of hydrogen and alkyl having up to six carbon atoms, and R 1 is hydrogen or allyl.
Claim 2
Dependent Claim
31 words
A compound of the formula: ##STR3## wherein R is selected from the group consisting of hydrogen and alkyl having up to six carbon atoms, and R 1 is hydrogen or allyl.
Claim 3
Dependent Claim
10 words
The compound according to claim 1 wherein R is hydrogen.
Claim 4
Dependent Claim
10 words
The compound according to claim 1 wherein R is methyl.
Claim 5
Dependent Claim
10 words
The compound according to claim 1 wherein R is ethyl.
Claim 6
Dependent Claim
10 words
The compound according to claim 1 wherein R is n-propyl.
Claim 7
Dependent Claim
10 words
The compound according to claim 1 wherein R is isopropyl.
Claim 8
Dependent Claim
10 words
The compound according to claim 1 wherein R is n-butyl.
Claim 9
Dependent Claim
10 words
The compound according to claim 1 wherein R is tert-butyl.
Claim 10
Dependent Claim
10 words
The compound according to claim 1 wherein R is n-hexyl.
Claim 11
Dependent Claim
11 words
The compound according to claim 1 wherein R 1 is allyl.
Claim 12
Independent Claim
50 words
The method of meliorating asthma in a mammal which comprises administering internally to said mammal an effective amount of a compound of the formula: ##STR4## wherein R is selected from the group consisting of hydrogen and alkyl having up to six carbon atoms, and R 1 is hydrogen or allyl.
Claim 13
Independent Claim
50 words
The method of meliorating asthma in a mammal which comprises administering internally to said mammal an effective amount of a compound of the formula: ##STR4## wherein R is selected from the group consisting of hydrogen and alkyl having up to six carbon atoms, and R 1 is hydrogen or allyl.
Claim 14
Dependent Claim
69 words
A therapeutic composition in dosage unit form useful for meliorating asthma in mammals comprising from about 1.0 mg. to about 25.0 mg. per kg. of body weight per daily dosage unit, in association with a pharmaceutical carrier, of a compound of the formula: ##STR5## wherein R is selected from the group consisting of hydrogen and alkyl having up to six carbon atoms, and R 1 is hydrogen or allyl.
Claim 15
Dependent Claim
69 words
A therapeutic composition in dosage unit form useful for meliorating asthma in mammals comprising from about 1.0 mg. to about 25.0 mg. per kg. of body weight per daily dosage unit, in association with a pharmaceutical carrier, of a compound of the formula: ##STR5## wherein R is selected from the group consisting of hydrogen and alkyl having up to six carbon atoms, and R 1 is hydrogen or allyl.
Claim 16
Dependent Claim
76 words
The process of preparing compounds of the formula: ##STR6## wherein R is selected from the group consisting of hydrogen and alkyl having up to six carbon atoms, which comprises heating a compound of the formula: ##STR7## wherein R' is methyl or ethyl and R is as hereinabove defined in a non-polar high boiling organic solvent at a temperature of 225°-275° C. for a period of time sufficient for a substantial degree of ring closure to occur.
Claim 17
Dependent Claim
76 words
The process of preparing compounds of the formula: ##STR6## wherein R is selected from the group consisting of hydrogen and alkyl having up to six carbon atoms, which comprises heating a compound of the formula: ##STR7## wherein R' is methyl or ethyl and R is as hereinabove defined in a non-polar high boiling organic solvent at a temperature of 225°-275° C. for a period of time sufficient for a substantial degree of ring closure to occur.
Claim 18
Dependent Claim
91 words
The process of preparing compounds of the formula: ##STR8## wherein R is selected from the group consisting of hydrogen and alkyl having up to six carbon atoms, which comprises heating a compound of the formula: ##STR9## wherein R' is methyl or ethyl and R is as hereinabove defined in a non-polar high boiling organic solvent at a temperature of 225°-275° C. for a period of time sufficient for a substantial degree of ring closure to occur, and thereafter alkylating resultant compound with an allyl halide to recover compound (I), above defined.
Claim 19
Dependent Claim
91 words
The process of preparing compounds of the formula: ##STR8## wherein R is selected from the group consisting of hydrogen and alkyl having up to six carbon atoms, which comprises heating a compound of the formula: ##STR9## wherein R' is methyl or ethyl and R is as hereinabove defined in a non-polar high boiling organic solvent at a temperature of 225°-275° C. for a period of time sufficient for a substantial degree of ring closure to occur, and thereafter alkylating resultant compound with an allyl halide to recover compound (I), above defined.
References Cited (Backward Citations)
US3840537A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-18 | 1982-03-20 | 1982-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-18 | 1986-03-20 | 1986-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-18 | 1990-03-20 | 1990-09-19 | $7700.00 | Window Closed / Lapsed |