Patent US2964597A successfully refreshed from Google Patents.
Patent US4309342A successfully refreshed from Google Patents.
US4309342A
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Antibacterial peptides
Assignee: Abbott Laboratories
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Filing: 1980-07-03
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Granted: 1982-01-05
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Expires: 2000-07-03
Abstract
Abstract It has been found that dipeptides containing a 3-fluoro-D-alanine N-terminus are powerful antibacterials and produce a highly useful synergistic effect with antibiotics.
Inventors
- 👤 Daniel T. Chu
- 👤 Jerry R. Martin
- 👤 Alford M. Thomas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 11:57
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06191
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
50 words
A dipeptide of the formula ##STR2## wherein the shown aminoacid is in the D-configuration, R is hydrogen or an easily removable, protective group, R' is hydrogen or deuterium and R" is a protein derived aminoacid in the L-configuration, or the corresponding loweralkyl esters, or a nontoxic acid addition salt thereof.
Claim 2
Dependent Claim
50 words
A dipeptide of the formula ##STR2## wherein the shown aminoacid is in the D-configuration, R is hydrogen or an easily removable, protective group, R' is hydrogen or deuterium and R" is a protein derived aminoacid in the L-configuration, or the corresponding loweralkyl esters, or a nontoxic acid addition salt thereof.
Claim 3
Dependent Claim
11 words
The dipeptide of claim 1 wherein R and R' are hydrogen.
Claim 4
Dependent Claim
9 words
The dipeptide of claim 2 wherein R" is alanine.
Claim 5
Dependent Claim
9 words
The dipeptide of claim 2 wherein R" is valine.
Claim 6
Dependent Claim
9 words
The dipeptide of claim 2 wherein R" is leucine.
Claim 7
Dependent Claim
10 words
The dipeptide of claim 2 wherein R" is glutamic acid.
Claim 8
Dependent Claim
10 words
The dipeptide of claim 2 wherein R" is α-amino-isobutyric acid.
Claim 9
Dependent Claim
9 words
The dipeptide of claim 2 wherein R" is phenylalanine.
References Cited (Backward Citations)
US3929576A
Cited
US3956367A
Cited
US4031231A
Cited
US4119620A
Cited
US4176116A
Cited
US4187216A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-01-04 | 1985-07-06 | 1986-01-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-01-04 | 1989-07-06 | 1990-01-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-01-04 | 1993-07-06 | 1994-01-05 | $7700.00 | Window Closed / Lapsed |