US4119620A
Expired / Lapsed
US
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Novel dipeptide derivatives, salts thereof, and method of measuring enzyme activity
Assignee: Ajinomoto Co Inc
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Filing: 1976-10-18
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Granted: 1978-10-10
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Expires: 1996-10-18
Abstract
Abstract The activity of X-prolyl dipeptidyl-aminopeptidase against X-L-proline-Y wherein X is an amino acid residue and Y is p-nitroaniline, p-phenylazoaniline or 4-phenylazo-1-naphthylamine is used as a measure of human afflictions such as hepatobiliary diseases and carcinomas.
Inventors
- 👤 Toshiharu Nagatsu
- 👤 Shumpei Sakakibara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 12:19
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/34; C12Q1/37; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06026; C07K5/06086; C07K5/06095; C07K5/06104; C07K5/06113; A; A61; A61K; A61K38/00; C12Q2337/00; C12Q2337/10; C12Q2337/12; C12Q2337/30; Y; Y10; Y10S; Y10S530/00; Y10S530/802
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
62 words
Dipeptide derivatives having the structure: X-L-proline-Y wherein X is a residue of an amino acid selected from the group consisting of glycine, alanine, valine, leucine, serine, threonine, phenylalanine, tyrosine, tryptophane, glutamic acid, aspartic acid, lysine and arginine; and Y is a residue of a compound selected from the group consisting of p-nitroaniline, p-phenylazoaniline, and 4-phenylazo-1-naphthylamine; and acid salts of said dipeptide derivatives.
Claim 2
Dependent Claim
62 words
Dipeptide derivatives having the structure: X-L-proline-Y wherein X is a residue of an amino acid selected from the group consisting of glycine, alanine, valine, leucine, serine, threonine, phenylalanine, tyrosine, tryptophane, glutamic acid, aspartic acid, lysine and arginine; and Y is a residue of a compound selected from the group consisting of p-nitroaniline, p-phenylazoaniline, and 4-phenylazo-1-naphthylamine; and acid salts of said dipeptide derivatives.
Claim 3
Dependent Claim
34 words
Compounds as set forth in claim 1, wherein said X is a residue of glycine, alanine, glutamic acid, aspartic acid, lysine or arginine and said acid is p-toluenesulfonic acid, hydrochloric acid or hydrobromic acid.
Claim 4
Dependent Claim
32 words
Compounds as set forth in claim 2, wherein said Y is p-nitroaniline residue, and the sterochemical configuration of said X is the L form, with the exception that X is glycine residue.
Claim 5
Dependent Claim
2 words
Glycyl-L-proline p-nitroanilide.
Claim 6
Dependent Claim
2 words
Glycyl-L-proline p-nitroanilide.
Claim 7
Dependent Claim
3 words
Glycyl-L-proline p-nitroanilide tosylate.
Claim 8
Dependent Claim
3 words
Glycyl-L-proline p-nitroanilide tosylate.
Claim 9
Dependent Claim
2 words
L-lysyl-L-proline p-nitroanilide.
Claim 10
Dependent Claim
2 words
L-lysyl-L-proline p-nitroanilide.
Claim 11
Dependent Claim
2 words
L-arginyl-L-proline p-nitroanilide.
Claim 12
Dependent Claim
2 words
L-arginyl-L-proline p-nitroanilide.
Claim 13
Dependent Claim
2 words
L-alanyl-L-proline p-nitroanilide.
Claim 14
Dependent Claim
2 words
L-alanyl-L-proline p-nitroanilide.
Claim 15
Dependent Claim
2 words
L-glutamyl-L-proline p-nitroanilide.
Claim 16
Dependent Claim
2 words
L-glutamyl-L-proline p-nitroanilide.
Claim 17
Dependent Claim
2 words
L-aspartyl-L-proline p-nitroanilide.
Claim 18
Dependent Claim
2 words
L-aspartyl-L-proline p-nitroanilide.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-09 | 1982-04-10 | 1982-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-09 | 1986-04-10 | 1986-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-09 | 1990-04-10 | 1990-10-10 | $7700.00 | Window Closed / Lapsed |