Patent US4296104A successfully refreshed from Google Patents.
US4296104A
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US
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Therapeutic dimethyl sulfoxide composition and methods of use
Assignee: Individual
•
Filing: 1979-08-30
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Granted: 1981-10-20
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Expires: 1999-08-30
Abstract
Abstract The use of urea and/or ethanol with pharmaceutical compositions containing DMSO is disclosed. The result is a reduction in the undesirable side-effects normally associated with the application of DMSO compositions, enhancement of the desired physiological effects produced by DMSO compositions, and other benefits. Specific compositions contain DMSO with urea and/or alcohol and may also contain NaCl, KCl and/or acetamide. The use of DMSO to reduce the mortality rate of fish treated by hyperosmotic delivery is also disclosed.
Inventors
- 👤 Robert J. Herschler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:24
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/46; A61K31/00; A61K31/095; A61K31/10; A61K31/16; A61K31/17; A61K33/00; A61K33/14; A61K8/40; A61K8/42; A61P; A61P29/00; A61Q; A61Q19/00; A61Q3/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
69 words
In a method for administrating dimethyl sulfoxide to a host, the improvement comprising reducing the side effects of malodorous breath and skin reactions normally associated with such dimethyl sulfoxide administration, comprising the step of: administrating to said host a composition comprising dimethyl sulfoxide and a side-effect reducing agent taken from the group consisting of urea, or ethanol or mixtures thereof in an amount which is effective for said purpose.
Claim 2
Dependent Claim
69 words
In a method for administrating dimethyl sulfoxide to a host, the improvement comprising reducing the side effects of malodorous breath and skin reactions normally associated with such dimethyl sulfoxide administration, comprising the step of: administrating to said host a composition comprising dimethyl sulfoxide and a side-effect reducing agent taken from the group consisting of urea, or ethanol or mixtures thereof in an amount which is effective for said purpose.
Claim 3
Dependent Claim
12 words
A method according to claim 1 wherein said composition further includes acetamide.
Claim 4
Dependent Claim
13 words
The method according to claim 1 wherein said composition further includes sodium chloride.
Claim 5
Dependent Claim
13 words
The method according to claim 1 wherein said composition further includes potassium chloride.
Claim 6
Dependent Claim
12 words
The method according to claim 1 wherein said composition further includes water.
Claim 7
Dependent Claim
19 words
The method according to claim 1 wherein the weight ratio of urea to dimethyl sulfoxide is greater than 1:99.
Claim 8
Dependent Claim
18 words
The method according to claim 1 wherein the ratio of urea to dimethyl sulfoxide is greater than 1:9.
Claim 9
Dependent Claim
48 words
The method according to claim 1 wherein said composition has the following formulation: ______________________________________
dimethyl sulfoxide
about 19 grams;
urea about 9 grams;
sodium chloride about 1 gram; and
water at least about 6 grams;
______________________________________ whereby the aforementioned composition formulation is provided with the weight ratios noted.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-19 | 1985-04-20 | 1985-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-19 | 1989-04-20 | 1989-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-19 | 1993-04-20 | 1993-10-20 | $7700.00 | Window Closed / Lapsed |